Review an analysis

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Recommended: Therapeutic cooling strategies after cardiac arrest

Review Analysis and Evaluation

DECLARATIVE TITLE:
In unconscious out-of-hospital cardiac arrest patients targeted temperature management at 330c did not show any reduction in mortality rate as compare to targeted temperature management at 360c.1

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION:
Article title: “Targeted temperature management at 330c versus 360c after cardiac arrest.”1
Bibliographic information: Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Aneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H; TTM Trial Investigators. Targeted temperature management at 330c versus 360c after cardiac arrest. N Engl J Med. 2013 Dec 5;369 (23):2197-206. doi: 10.1056/NEJMoa1310519. Epub 2013 Nov 17

PURPOSE/QUESTION:
The purpose of the study was to evaluate effect of targeted temperature management (TTM) at 330c compare to TTM 360c on survival and neurological benefits in unconscious out-of-hospital cardiac arrest patients.1

SOURCE OF FUNDING:
“The study was funded by the Non-profit, foundation or government agencies, Swedish heart lung Foundation, AFA insurance foundation, The Swedish research council, Regional research support, Regional skane, Governmental funding of clinical research within the Swedish national health services, Thelma Zoega Foundation, Krapperup Foundation, Thure Clarlsson Foundation, Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research, Skane University Hospital, Swede, TrygFoden, Denmark and the European Clinical Research Infrastructures Network.”1

TYPE OF STUDY/DESIGN:
The study was parallel, multicenter, randomized and stratified trial. The study

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