Psychological Stress and Immunity

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Events that provoke stress are known as stressors, this covers a wide range of situations. Stressors can be anything from a risk of physical danger to taking an in-class exam or even conducting a presentation at work. The human body responds to these stressors by activating the nervous system and specific hormones such as adrenaline and cortisol. The adrenal glands are signaled by the hypothalamus to produce more of these hormones and then to release them into the bloodstream. The hormones adrenaline and cortisol increase breathing rate, heart rate, blood pressure and metabolism. Blood vessels then dilate to allow more blood flow to reach large muscle groups; pupils also dilate to improve vision. The liver then releases stored glucose in order to increase the body's energy, thus sweat is produced to cool the body (Neil et al., 2007). All of the physical changes prepare one’s body to react quickly and effectively so that the pressure of the moment can be handled in a controlled way. This natural reaction is known as the stress response. The body's stress response can enhance a person's ability to perform well under pressure if it is functioning properly, however, the stress response can also be hazardous, causing serious problems if it overreacts or fails to reset itself properly. Many physiologists today also define stress as the body’s reaction to a stressor. Acute stressors affect an organism in the short term where as chronic stressors affect an organism over a longer period. Hans Hugo Bruno Selye, the Canadian endocrinologist researched the effects of stress and found that stress differs from other physical responses. He believed that stress is a stressful experience regardless if one receives good or bad news, and even whether the impulse is positive or negative. He defined negative stress as a distress and a positive stress as a eustress (Obama et al., 2007). In 1936, Selye researched a model on stress known as the General Adaptation Syndrome (GAS) where he experimented on rats by injecting them with extracts of various organs. The experiment of rats can show if the organism is severely damaged by acute nonspecific nocuous agents, examples include exposure to cold, production or transcision of the cord (spinal shock), surgical injury, excessive exercise, and intoxications of lethal drugs such as morphine, adrenaline, atropine, and formaldehyde (Selye, 1998). During the course of his research, Selye described the effects of stress in three key stages; these stages explain how the human body may become susceptible to infections and diseases.

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