Protein Paper

609 Words3 Pages
Pyruvate Dehydrogenase Kinase (PDK), may go by many name such as PDK4, PDC, and so on is a protein that serves as many functions in both mammalians and Plantae. In humans, one of its functions is that it serves as a decarboxylation of substrate 1, which is pyruvate (Frank, 2005). Inhibition of PDK4 leads to higher amounts of glucose oxidation, which helps to make more pyruvate into acetyl-CoA (Zhang, 2014). This decarboxylation of substrate 1 functions to produce carbon dioxide (Frank, 2005). PDK is responsible for metabolic flexibility in animals, it overseas the utilization and repository of fuel to help establish the flexibility of metabolism as a response to nature (Zhang, 2014). Pyruvate Dehydrogenase Kinase’s main role for metabolic flexibility is to help function as a regulator of energy homeostasis (Zhang, 2014). Pyruvate Dehydrogenases Kinase serves also as a function and a scientific discovery in the nervous system. The brain, which gets most of its oxygen from the metabolism of glucose and Pyruvate Dehydrogenase Complex (PDC) in the mitochondria, functions as the key to regulate the oxidation of glucose (Jha, 2012). PDK’s system helps to act as regulator of the activity that comes within the mitochondria and helps to switch from oxidative phosphorylation to aerobic glycolysis (Jha, 2012). Pyruvate Dehydrogenase Kinase’s metabolic communication link together the advancement of multiple neurological disorders. One neurological disorder that PDK interacts with is Alzheimer’s disease, due to the inhibition of PDK the lipids and glucose in the brain has decreased and peroxided leading to certain characteristics of this neurological disorder (Jha, 2012). Another disease that PDK helps to fuel is cancer, more specifically Glio... ... middle of paper ... ...3-403 Ke J, Behal H.R., Back L.S., Nikolau J.B., Wurtele S.E., Oliver J.D. 2000. The Role of Pyruvate Dehydrogenase and Acetyl-Coenzyme A Synthetase in Fatty Acid Synthesis in Developing Arabidopsis Seeds. 123(1): 497-508 Mendez T.A., Miernyk A.J., Randall D.D. 2003. Regulation in pyruvate dehydrogenase complex activity in plant cells. 270(1): 1043-1049 Piao L, Fang H.Y., Cadete J.J.V., Wietholt C, Urboniene D, Toth T.P., Marsboom G, Zhang J. H., Haber I, Rehman J, Lopaschuk D.G., Archer L.S. 2010. The inhibiton of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right and ventricular hypertrophy: resuscitating the hibernating right ventricle. 88(1): 47-60 Zhang S, Hulver W.M., McMillan P.R., Cline A.M., Gilbert R.E. 2014. The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility. 11(1): 10
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