Presentation on Anti-Malaria Mosquitoes

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The Malaria Protozoan parasite, of the genus Plasmodium.

There are two main types of Plasmodiumthat infect humans

Plasmodium Falciparum

Plasmodium Vivax

Transmitted by female mosquitoes

Develops in mosquito gut

Migrates to salivary glands

Transfers to other organisms through the saliva of the mosquito.

The Mosquito

A mosquito is an organism of the family Culicidae. The females require a blood meal to develop eggs.

The mosquito vector for malaria is the mosquito genus Anopheles.

Transfers Plasmodiumthrough saliva while feeding on blood.

Malaria, mosquitoes, and humans

A Mosquito-borne disease

Malaria is widespread, and very common in parts of the Americas, Asia, and most of Africa.

No vaccine available

Only medicine is preventative drugs that must be taken continuously.

If infected, there is some antimalarial medication available, most notably quinine.

Some other preventative measures can be taken

Mosquito netting


Draining standing water

So, what is this “Anti-malaria mosquito?”

An anti-malaria mosquito is a mosquito that is immune to malaria.

This is good because

The malaria will die inside the mosquito instead of continuing its life cycle.

The mosquito will not be able to transmit the malaria to other organisms.

There are multiple ideas of how to create such a mosquito.

Transgenic mosquito

Modified symbiont

The transgenic mosquito

A transgenic anti-malaria mosquito is a mosquito that has had a gene inserted to make it kill the malaria while it develops in the mosquito.

There have been many genes tested, including ...

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... the genus Asaia stably associate with Anopheles stephensi, an Asian malarial mosquito vector." Proceedings of the National Academy of Sciences 104(2007): 9047-9051.

Li, Chaoyang, Mauro Marrelli, Guiyan Yan, Marcelo Jacobs-Lorena. "Fitness of Transgenic Anopheles stephensi." Journal of Heredity 99(2008): 275-282.

Favia, G. “Bacteria of the Genus Asaia: A Potential Paratransgenic Weapon Against Malaria” Transgenesis and the Management of Vector-Borne Disease 627(2008):49-59.

Yoshida, S. "Bacteria expressing single-chain immunotoxin inhibit malaria parasite development in mosquitoes." Molecular and biochemical parasitology 113.1 (2001):89-96.

Bibliography Ctd.

Knols, B. "Transgenic mosquitoes and the fight against malaria: Managing technology push in a turbulent GMO world." The American journal of tropical medicine and hygiene 77.6, Suppl. S (2007):232-242.
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