Polycystic Kidney Disease, also known as PKD, is a common inherited gene disorder that causes the growth of cysts in the tissues of both the kidneys. The kidneys are a major organ in the excretory system; they remove wastes from the blood and form of urine. They filter the blood, keeping it clean of all wastes and have a number of other functions as well. Due to the growth of cysts on the kidneys it makes it hard to carry out these functions and the will eventually cause the kidneys to fail. This paper will discuss what PKD is, the many symptoms and treatments of PKD, and recent developments in research of this disease.
Polycystic Kidney Disease
Description and Affects
Polycystic Kidney Disease, often referred to as PKD, is a genetic disorder passed down through families and involving bilateral renal cysts, usually without abnormality. The kidneys are located in the upper part of the abdomen, toward the back, and about the size of one’s fist. They filter waste and unneeded fluid from the blood and form urine. When cysts form in or on the kidneys they fill with fluid and become enlarged. The enlargement of the kidneys will result in decreased function and eventually kidney failure. There are two major forms of PKD, autosomal dominant (ADPKD) and autosomal recessive (ARPKD). Both of these can involve the presence of renal cysts at any time during an affected person’s life, from prenatal stages into adulthood.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. This type is passed from parent to child by an autosomal dominant type of inheritance. This means that only one copy of the abnormal gene is needed to cause the disease. Therefore, if one p...
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...r a period of time, like blood pressure and quality of life, in order to better understand the course of the disease. No drugs are given, but other types of interventions are made during the time of the study. Interventional studies also monitor and record various factors over a period of time while testing experimental treatments, devices or combinations of drugs to see if the disease outcome is altered.
Works Cited
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Kielstein and Hans‐Martin give a case example of a 55 year old female dialysis patient who was diagnosed as a carrier of a dominant genetic disorder: Autosomal dominant polycystic kidney disease (ADPKD). She had four sons who underwent screening and were identified as carriers. One of her sons was 32 years old and the father of a six year old when he first developed symptoms of ADPKD. He committed suicide. Another son, who was 30 years old, divorced his wife and sold their home to keep from burdening her or planning a family. He did not have problems until he was 54. A third son was 25 and left his fiancée for the same reason. He later died from another cause without having ever developed symptoms. The fourth son was 21 when identified as a
Glomerulonephritis, as a defined disease, is very broad in terms of a medical condition and is usually only diagnosed after a routine medical check-up or tests for another condition discover; the symptoms may not be obvious. This disease targets the membrane tissues made of tiny filtering cluster units within the kidneys called glomerulus, which comes from a Greek word meaning filter (NIH, 2014). This illness presents as an inflammation of the tiny filtering units called glomeruli of the kidneys that can be caused by a passing illness associated with an infection or as a result of an autoimmune disease (Nemours, 1995-2016). Glomerulonephritis is a multi-symptom disease caused by genetics or environmental factors that can have variable degrees
Kidneys play an important role in the unary tract. They are located on each side of the spine, just below the ribcage. Each kidney is connected to the bladder by ureters. The kidneys have many functions, but the most common functions are to clean waste, control chemicals, and regulate fluid in the body which makes up the urine. Urine collects in the kidney before entering the ureters and as time passes more materials are added. When calcium and oxalate or phosphates are combined in the kidney tiny stones are formed called nephrolithiasis, commonly known as kidney stones. These stones can be very painful and “increases risks for diabetes, high blood pressure, and osteoporosis” (Goldfarb, 2009). About ten percent of all people will have kidney stones in their lifetime. Kidney stones are most frequently found in white men over the age of forty, relatives of kidney stone patients, and people who have formerly had kidney stones.
Takeda, Taylor, Khan, Krum, & Underwood. (2012) states ‘(1) case management interventions (intense monitoring of patients following discharge often involving telephone follow up and home visits); (2) clinic interventions (follow up in a CHF clinic) and (3) multidisciplinary interventions (holistic approach bridging the gap between hospital admission and discharge home delivered by a team). The components, intensity and duration of the interventions varied, as did the ‘usual care’ comparator provided in different trials’. (P. 2).
Nephrolithiasis or kidney stone formation is a common form of renal disease characterized by crystal deposition in the renal medulla as a result of urinary supersaturation (Worcester and Coe 2009). It is the second most common kidney condition, and kidney stones affect approximately 6-12% of the United States population with the most affected subpopulation being Caucasian males. Nephrolithiasis is considered a systemic disorder that is associated with chronic kidney disease, an increased risk of coronary artery disease, bone loss and fractures, and type 2 diabetes mellitus (Sakhaee et al. 2012).
...her form is the use of procedures or drugs, which may be directly beneficial, such as a drug to control the symptoms of schizophrenia. The final type of research is that which is trying to find a better treatment, or the cause of the disease, but most likely won't be a benefit to the patient. An example of this would be performing tests on a schizophrenic to help develop a cure for schizophrenia. That would not benefit the individual because most likely by the time the drug is ready to be prescribed the patient would be dead.
United States Renal Data System (USRDS). (2008). Annual data report: Incidence and prevalence. Retrieved July 8, 2009, from http://www.usrds.org/2008/pdf/V2-02-2008.pdf
This article is for people whose kidneys fail to work. This condition is called end-stage renal disease (ESRD).
blocked has now shut down. This kidney, if left untreated for just a few days,
Suffering from a unique anomaly, gave me not only some difficulties in life, but sparked my interest in a world of opportunity, cures, and advanced technology. Crossed fused ectopia is a condition where both my kidneys are fused together at the midline instead of the sides. Therefore, contact sports, such as horseback riding and soccer, that put my kidneys at risk of harm was forbidden. Complication for this kidney disease such as a UTI, infections, and hydronephrosis are increased by 50%. This congenital disease made me wonder if it was hereditary or acquired. Therefore, when I saw a nephrologist, the doctor kept questioning my parents to find more about some family diseases that can give insight into this condition. Both of my parents’ relatives
From the results of the numerous tests carried out according to the patient history of frothy urine with a significant oedema over a maximum period of 5 days, the patient was diagnosed with Nephrotic Syndrome. This is condition that occurs due to leakage in the kidney filtration part leading to a large amount of protein leaking from the blood into the urine. This is mainly due to fluid retention known as oedema which is as a result of low protein level in the blood. It occurs due to abnormal functioning or a part of the kidney is affected (glomeruli). This syndrome can be caused by numerous diseases coming together to cause or form one particular disease; these causes range from minimal change disease, membranous nephropathy, focal segmental glomerulosclerosis (FSGS) and other conditions, disorders of the glomeruli. The membranous nephropathy also known as the membranous nephritis or membranous glomerulonephritis, only causes diseases in adults and very uncommon in children. Leakage occurs from this due to the thickening of the membranous in the glomeruli which is the filter of the glomeruli. Focal segmental glomerulosclerosis is a causative due to the formation of small scars (sclerosis) on some of the kidney glomeruli. Another form of cause of nephrotic is minimal change which is due to lack of virtual change detected in the glomeruli when examined under the microscope. This causes the syndrome in 9 out of a total of 10 children under the age of 5 years.
2. (2012, 02). Phenylketonuria. Your Guide to Understanding Genetic Conditions. Retrieved 04, 2014, from http://ghr.nlm.nih.gov/condition/phenylketonuria
Clinical trial is biomedical or health related research studies in human being that follow a pre-defined protocol. Research is an activity designed to test a hypothesis that helps in concluding and developing knowledge. It is a protocol that has an objectives and procedures to reach those objectives (1). There are two types of clinical studies. One is interventional studies in which the research subjects are assigned by the investigator to a treatment or other intervention, and their outcomes are measured. Second is an observational study in which individuals are observed and their outcomes are measured by the investigators.
Kidney Function Introduction and definition of terms: The kidneys are the main organs in the urinary system. They filter waste products out of blood from the renal artery. These are then excreted. Useful solutes are reabsorbed into the blood. They also have a major homeostatic role in the body, and help to control the water content (osmoregulation) and pH of the blood.
Chronic Kidney Disease. Mayo Foundation for Medical Education and Research, 2014. Web. 20 May 2014.