Poliomyelitis, infectious virus disease of the central nervous system, sometimes resulting in paralysis. The greatest incidence of the disease, also known as infantile paralysis, is in children between the ages of five and ten years. The disease was described in 1840 by the German orthopedist Jacob von Heine. In its clinical form it is more prevalent in temperate zones.
Symptoms
The virus usually enters the body through the alimentary tract and spreads along nerve cells to affect various parts of the central nervous system. The incubation period ranges from about 4 to 35 days. Early symptoms include fatigue, headache, fever, vomiting, constipation, stiffness of the neck, or, less commonly, diarrhea and pain in the extremities. Because nerve cells that control muscular movement are not replaced once they are destroyed, poliovirus infection can cause permanent paralysis. When nerve cells in respiratory centers, which control breathing, are destroyed, the victim must be kept alive by an iron lung (see Artificial Respiration). For every paralytic case of poliomyelitis, however, there may be 100 nonparalytic cases.
Treatment
Because no drug developed so far has proved effective, treatment is entirely symptomatic. Use of moist heat coupled with physical therapy to stimulate the muscles was first initiated by the Australian nurse Elizabeth Kenny, and antispasmodic drugs are administered to produce muscular relaxation. In the convalescent stage, occupational therapy is used.
Disease Control
Three broad types of the virus have been identified: the Brunhilde (type 1), Lansing (type 2), and Leon (type 3) strains. Immunity to one strain does not furnish protection against the other two.
Poliomyelitis control was made possible when, in 1949, the American bacteriologist John Franklin Enders and his coworkers discovered a method of growing the viruses on tissue in the laboratory. Applying this technique, the American physician and epidemiologist Jonas Salk developed a vaccine prepared from inactivated poliomyelitis viruses of the three known types. After field trials in 1954 the vaccine was pronounced safe and effective, and mass inoculation began. The American virologist Albert Sabin subsequently developed a vaccine containing attenuated, live polio virus that could be given orally.
Salk’s research led him to create a vaccine different from any other by using 3 different kind of killed polio virus. In an article it says,”Using formaldehyde, Salk killed the poliovirus, but kept it intact enough to trigger the necessary immune response”(Salk’s institute 1). Salk 's decision to create a vaccine out of inactivated virus was not the strongest protector, but was made strong enough to cure and lower the risk of infection within patients. It was one of the first times someone attempted to take a completely opposite approach than what scientist thought was best. As he said in an interview, “ ‘The principle I was trying to establish was that it was not necessary to run the risk of infection, which would have been the case if one were to try to develop an attenuated or weekend polio virus vaccine’ ”( Salk 2). By taking the risk of creating a vaccine that contradicted what a normal vaccine, was it helped give the United States another weapon to fight back polio without exposing americans to the risk of contracting the disease. His different approach to find a remedy may have been looked down on, but it provided the first protection ever for polio which created hope and has contributed to less fatalities today. Scientists in the medical world began to criticize Salk’s vaccine and gave preference to a polio vaccine that was later created by Sabin out of a live polio virus. Medical professionals saw Salk’s vaccine as useless and thought Sabin’ s vaccine was the best alternative. "the oral polio vaccine also came under attack in the united states for causing eight in ten cases of polio every year”( poliomyelitis 4). Sabin’s vaccine may have been stronger but at least Salk’s never provided a risk of the patients being injected run a risk of being infected again. Salk’s vaccine has provided less risk of a patient to relapse into polio again.
At first polio was a troubling prospect when it first reared its ugly head in the United States of America. In a noble effort to be rid of polio, America as a whole was to adopt stringent sanitation measures. Everywhere, especially the home was to be spotless and clean in order to try and prevent the contraction of polio. This coupled with the view that America as a western nation seemed impervious to such a lowly disease tried to assuage American fear of the disease. Despite the measures commonly adopted throughout the myriad of cities and towns, polio still managed to spread around the country and wreak havoc taking thousands of lives. An outbreak that ravaged America claimed nearly 27,000 lives in a terrible reckoning before it finally subsided. This and several other troubling outbreaks
[1, 4, 5, 9, 13] There have been no documented cases where a human has contracted the disease from another human. [4] It appears, based on field and lab data, that infection requires direct contact with the virus through means such as contact with infective bodily secretions, urine, or tissues. [12] It is unknown to scientists how the virus can be maintained in the bat populations and avoids extinction as the host species becomes immune to its presence. [14] The incubation period from time of infection to the onset of symptoms is about 5-14 days in experimentally induced animals [4] and 8-14 days in natural field cases.
there is a disease-causing agent involved with Guillain-Barre it has been classified as a disorder,
The death rate was on the decline and life expectancy rose during this period. New medical developments were made with the federal funding of medical research in which penicillin and streptomycin were developed. These advancements in medicine have cured many bacterial infections and severe illnesses. Later, in 1952, Jonas Salk introduced a polio vaccine. There was a vast migratory pattern among many Americans during this time period.
One of the other notable important advances was the “Conquest of Polio” this disease usually caused paralysis in the people who contracted the virus. Back then there...
Poliomyelitis was declared an epidemic in the early 1950s in the United States. It caused primarily children and young adults to develop paralysis, led to social stigma around being crippled. To this day there is still no cure for this disease, poliomyelitis can only be prevented with vaccination.
Polio is a viral disease. It cripples thousands of people and infects even more every year. Even though millions are inoculated, and the polio disease has been successfully purged from hundreds of countries still thousands of people and developing countries are infected and still people are dying. According to the World Health Organization (WHO) polio affects the Central Nervous System, or CNS; by infesting the intestines and transmitting it into the nerves thought the blood vessels. There the virus spreads through the nerve cells to the brain stem or other motor units, while forever damaging the nerves.
The virus is primarily spherical shaped and roughly 200nm in size, surrounded by a host-cell derived membrane. Its genome is minus-sense single-stranded RNA 16-18 kb in length. It contains matrix protein inside the envelope, hemagglutinin and neuraminidase, fusion protein, nucleocapsid protein, and L and P proteins to form the RNA polymerase. The host-cell receptors on the outside are hemagglutinin and neuraminidase. The virus is allowed to enter the cell when the hemagglutinin/ neuraminidase glycoproteins fuse with the sialic acid on the surface of the host cell, and the capsid enters the cytoplasm. The infected cells express the fusion protein from the virus, and this links the host cells together to create syncitia.
Envision a life consumed by grayness and misfortune, slowly weakening the body from the inside with no proof of existence other than symptoms of a common cold. Dwindling away as skin begins to cling to bone, this monster, formally addressed as the Poliomyelitis (Polio) disease, finds its way to the nerves of the body as well as the grey areas of the spinal cord, leaving its host with dreadful affects throughout the body.Since its discovery in 1905, Polio has caused several epidemics throughout the years leaving many permanently paralyzed or even dead. Thankfully, scientists created the polio vaccination which lead to the nearly complete eradication of this disease. However, In order to ensure this disease does not spread as it once did before, people must come to understand Polio’s etiology, history and modern day epidemiology, as well as its proper response to treatment.
The first discovery was made in 1952, in the developing field of virology. Virology is the study of viruses and how they behave. To develop the vaccines for the viruses, researchers infected the HeLa cells with many types of infections, such as measles, mumps, and the infamous poliomyelitis virus, also known as Polio. According to the Centers for Disease Control and Prevention (CDC), whose mission is to save lives and protect people’s health security, Polio is a "crippling and potentially deadly infectious disease caused by a virus that spreads from person to person invading the brain and spinal cord and causing paralysis" (Freeman). Jonas Salk, who was a virologist at the National Foundation for Infantile Paralysis (NFIP), used inactivated viruses (virus particles grown in culture and then killed by a form of heat) to create a polio vaccine. Salk drew blood from about two million children, which the NFIP checked for immunization.Through the collection of many HeLa cells and trial and error, the polio vaccine wa...
Polio: An American Story describes a struggle to find a vaccine on polio through several researchers’ lives, and over the course of many years. The second thesis is the struggle between Salk and Sabin, two bitter rivals who had their own vaccine that they believed would cure polio. The author David M. Oshinsky, is describing how difficult it was to find the cure to a horrifying disease, which lasted from the Great Depression until the 1960’s. Oshinsky then writes about how foundations formed as fundraisers, to support polio research. Lastly, the author demonstrates how researchers were forced to back track on multiple occasions, to learn more about polio.
Moreover polio is a deadly disease that is caused by a highly contagious virus entering the nervous system in the brain or spinal cord causing temporary or permanent paralysis. There are three
years, and there is still no cure, but at the peak of its devastation in the United