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In 2008, there were an estimated 263,900 new cases and 128,000 deaths as a result of oral cavity cancer worldwide. Major risk factors for this specific type of cancer includes smoking, alcohol use, smokeless tobacco products, and HPV infections. Studies have shown that synergistic effects are displayed by smoking and alcohol. The burden which occurs due to the contribution of these risk factors varies across regions. Smoking is responsible for 42% of deaths from cancers of the oral cavity (including pharynx) and heavy alcohol consumption for 16% of the deaths worldwide; the corresponding percentages in countries with high income are approximately 70% and 30% respectively (Ahmedin Jemal, et al., 2011).