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Overview of penicillin
Penicillin discovery essay
Discovery of penicillin the first miracle drug
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Recommended: Overview of penicillin
Austin Faw
What is penicillin
Penicillin by definition is an antibiotic produced by a blue mold that will sometimes grow on trees but it can also be made synthetically
Penicillin is important because it defeated smallpox which killed over 300 million people, without any antibiotics you had 60% chance of surviving. Today penicillin is one of the most used medicine out their and led to today's advancements in medical science.
The Discovery
Alexander fleming was suffering from a terrible cold.
He decided to culture his mucus,the petri dish became contaminated by microorganisms, either from laboratory dust or wind from outside.
Two weeks later, fleming noticed that one of the mucus had grown golden bacteria. They did not grow everywhere,
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Testing this diluted form,he discovered it would still kill bacteria when it was only 1/500 of it's original strength.
Fleming eventually identified the mold as one of a well known group of brush shaped organisms called penicillium, from the latin word for firn paintbrush . this type showed that it had bacteria killing properties he decided to call it penicillin.
As with lysozyme, flemming tried to find where else penicillin could be found, testing molds from decayed food, rags, and old boots.
Meanwhile, the original penicillin was tested for harmful side effects on mice rabbits, and a human volunteer -- flemings assistant,stuart craddock.
Fleming was revived to find none.
Unfortunately , it proved difficult to keep penicillin active long enough to try it out as a treatment for actual patients.
It's bacteria killing powers faded after a few days, and fleming was not a good enough chemist to stabilize it, which would later be done by howard
This was a factor that was based on chance, as the penicillin (mould) had probably blown through a window. In my opinion Fleming didn't have much do to with the development of Penicillin, but he did recognise its importance and published his findings. Florey and Chain were scientists. They stumbled across Fleming's research papers and were intrigued by his findings. They were sure that, if Fleming was right, this discovery could save a lot of lives, prevent pain and make it much easier to fight infectious diseases and prevent other infections.
Adegoke AA, Tom M, Okoh AI, Jacob S (2010) Studies on multiple antibiotic resistant bacterial isolated from surgical site infection. Scient Res. Essays 5:3876-81.
Years later other scientists were also intrigued by the possibilities of penicillin and produced enough penicillin to prove that it was a useable antibiotic. The scientists from Great Britain were developing all of this during World War II, and unfortunately funding for their drug was unavailable due to the war. They decided to bring their concepts to the United States, and once enough was made, it was eventually used, to treat wounded soldiers during World War I.
My disease is Streptococcal pneumonia or pneumonia is caused by the pathogen Streptococcus pneumoniae. Streptococcus pneumoniae is present in human’s normal flora, which normally doesn’t cause any problems or diseases. Sometimes though when the numbers get too low it can cause diseases or upper respiratory tract problems or infections (Todar, 2008-2012). Pneumonia caused by this pathogen has four stages. The first one is where the lungs fill with fluid. The second stage causes neutrophils and red blood cells to come to the area which are attracted by the pathogen. The third stage has the neutrophils stuffed into the alveoli in the lungs causing little bacteria to be left over. The fourth stage of this disease the remaining residue in the lungs are take out by the macrophages. Aside from these steps pneumonia follows, if the disease should persist further, it can get into the blood causing a systemic reaction resulting in the whole body being affected (Ballough). Some signs and symptoms of this disease are, “fever, malaise, cough, pleuritic chest pain, purulent or blood-tinged sputum” (Henry, 2013). Streptococcal pneumonia is spread through person-to-person contact through aerosol droplets affecting the respiratory tract causing it to get into the human body (Henry, 2013).
Penicillin is the reason people lived healthy and long lives. Sick, cold, and sore, are feelings people have when they are sick. If people were to become sick and penicillin was not around they would have those feelings for a longer duration. Penicillin was an idea that belonged to a famous scientist by the name of Sir Alexander Fleming. Penicillin was just the slightest of idea in Fleming’s mind after he married his wife who had the profession of a nurse. Fleming made penicillin after conducting test on accidentally infected fungus inhabited plates. He tried washing the fungus of with disinfectant, then he noticed a yellow-green zone around the fungus. He came up with the conclusion that penicillin’s main goal would be to eliminate the outer weak ring
Norman Heatley and Howard Florey went to America to figure it out, luckily they were able to find a gold colored mold that was two-hundred percent more effective. In World War I, pneumonia was eighteen percent of the reason for soldiers’ deaths; with the use of penicillin, in World War II pneumonia was responsible for only one percent of all deaths. Without this miracle drug, millions of people would have died from pneumonia in not only World War II but also civilians today. Penicillin changed the way infections were treated, landing it the number five spot in the top ten greatest inventions
Ernest Chain and Howard Florey with the knowledge of Flemings work were able to successfully purify an extract of penicillin for testing. The tested it in 1940 on mice, they concluded that those who were given the penicillin lived whereas the others did not. Later in 1945 all three men received the Nobel Prize for their contr...
The purpose of this paper is to review and summarize an article concerning antibiotic resistance. The article chosen was “The role of healthcare strategies in controlling antibiotic resistance” by Ann-Marie Aziz (2013) published in British Journal of Nursing, Vol. 22 Issue 18. This article discusses essential components to understand how antibiotics work; different strains of bacteria; what antibiotic resistance means and consists of; antibiotic resistance when pertaining to the production of foods. Along with strategies that can be utilized in health care to help reduce antibiotic resistance. For example, prescribing adjustments, sampling and testing; committees and education for staff and patients.
The scientist, Alexander Fleming, had just discovered and destroyed the world’s first anti biotic, penicillin. When he was disposing of the mouldy samples, he had no idea what he was doing. When he learnt of what he had done, he was very distressed. Fortunately, he was able to recover enough of the disposed samples that he was able to cultivate more penicillin, without which none of us would probably be here today.
Thesis: With the advent of antibiotics in 1929 Fleming said, "The time may come when penicillin can be bought by anyone in the shops.Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant."With the overuse of antibiotics today we have seen this very idea come to be.Over usage is caused most prevalently by a lack of education on the part of the patient.Thus stated, the way to overcome such a circumstance is to educate, not only the patient but also the physician.
Medical science and pharmaceutical researchers need to vigorously investigate the many factors contributing to the decline in antibiotic efficacy which will then empower them to research and develop a new generation of antibiotic therapies. Aligned with this is the responsibility of each individual to manage their health and expectations with regard to treatment. For example, individuals could adopt better ways of maintaining their immune systems by means of a healthy diet and exercise.
Fleming’s most famous discovery, however, is that of penicillin, and again, it occurred quite by accident. Echoing the discovery of lysozyme, the story of penicillin begins with a contaminated bacterial culture, this time with a mold. Again, Fleming allowed the culture to mature, and found that the growth of the bacteria had been severely inhibited by the presence of the mold, which was later identified as a member of Penicillium. Fleming and his team did not, however, manage to convert the antibiotic into a useful form, so they shared the 1945 Nobel prize with the researchers that did.
When Alexander Fleming published his experiments with penicillin, the Australian doctor set a goal to make this for mass medical use. So Florey and a scientist named Norman Heatley came to the U.S came with a small amount of penicillin to try and figure out how to grow in mass quantities. In an article written by Mary Bellis, it states that air was pumped deep into vats containing corn steep liquor, and other ingredients made penicillin grow larger amounts and faster. And in only 3 months they had succeeded in producing mass amounts of penicillin and fast. In 1943, multiple clinical trials were performed and penicillin was the most effective antibacterial agent to date. All, thanks to Florey, Heatley, and many other working in the lab, penicillin would begin to be used
Penicillin is a rare type of mold that kills bacteria. The discovery of penicillin was made by a scientist named Alexander Fleming. Penicillin was actually discovered by accident when Alexander Fleming left his house for vacation and when he came back he found that there was mold on his dishes and he immediately examined the mold. Fleming was credited with the discovery of penicillin, Florey was credited with making it into a medicine, and Morey was credited with the mass production of penicillin. Most of the development of penicillin happened in the 1900’s but the discovery of penicillin was in 1890.
The circumstances then were unsanitary and penicillin was unheeded. Penicillin basically refers to any group of substances that are chemically similar and are obtained from molds of the Genus Penicillin. Penicillin was the first medicine discovered that successfully treated the bacterial infections caused by bacteria belonging to the genus of staphylococci. In the beginning, small amounts of penicillin were obtained from strains of mold P. Notatum. There are seven main classes of antibiotics.