Pathophysiology Behind Labor Pain Case Study

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1. What is the pathophysiology behind labor pain? Pain associated with labor is distinguished from other sources of pain. The source of pain form uterine contractions is not entirely clear either. One key source is the distention of the lower uterus and cervix. The pain is more intense as the contractions are stronger. The stronger the contraction the stronger the pressure exerted. Uterus ischemia is thought to be less likely of a factor because blood flow is increased during contractions. There are however several chemical nociceptive mediators that may play a role. These include bradykinins, leukotrienes, prostaglandins, serotonin, lactic acid, and substance P. A uterine contraction is transmitted via A delta and C visceral afferent fibres …show more content…

With the onset of labor the hormone estrogen is elevated so that it higher than progesterone, thereby reducing the relaxing effects of progesterone on the muscle. The rise in estrogen levels increases the uterus sensitivity to other factors that will stimulate uterine contractions. These include prostaglandins from the fetal membranes, and oxytocin from the mother’s posterior pituitary gland. The estrogen also increases the number of gap junctions which are connections that allow the uterine muscles to contract as a unit. Prostaglandins, which are produced by the deciduas and membranes, help to prepare the uterus for oxytocin stimulation at term. Once labor has begun, oxytocin helps to maintain labor. Oxytocin does not alone initiate labor, but it may work in conjunction with other substances. There is also evidence of fetal oxytocin secretion. Oxytocin receptors in the uterus, at the start of labor, increase considerably and reach their peak at the time of delivery. The oxytocin will have little effect if the receptors on the uterine muscle are not developed. The fetus, it seems, also plays a role. The fetal membranes release prostaglandins in large amounts during labor. Along with the fetal oxytocin concentrations released, fetal cortisol is also released in large amounts due to the fetal adrenaline. The release of cortisol acts as a possible uterine stimulant. For labor …show more content…

Oestrogen is responsible indirectly for lactation. When the baby first starts to suckle on the breast this sends a sensory signal from the nipple to the brain. The anterior lobe of the pituitary gland then secretes prolactin and the posterior lobe secretes the oxytocin. For the cells of the alveoli to secrete milk, prolactin is necessary. Prolactin increased during pregnancy considerable and its role is to stimulate the growth and development of mammary tissue. During pregnancy however, progesterone and oestrogen are increased and so they block the action of prolactin. After delivery, their levels decrease rapidly and so the prolactin is no longer blocked. This is where the milk secretion begins. Each time the baby suckles the blood levels of prolactin increase and stimulate further milk production by the alveoli. The levels of prolactin are highest 30 minutes into a feeding so it can get ready for the next feed. It is important to know that the more the baby suckles the more milk is produced; it is a supply and demand scenario. After a couple weeks the association between amounts of prolactin an milk produced is decreased. But even still, if the mother stops breastfeeding the milk production will stop. Breastfeeding can also play a role in delaying pregnancy. The suckling releases pituitary hormones that include gonadotrophin releasing hormone (GnRH), follicle stimulating

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