Pathogen that Causes Histoplasmosis: Dr. Samuel Darling

1769 Words8 Pages
Introduction H. capsulatum is a most common true pathogen that causes histoplasmosis, and was discovered by Dr. Samuel Darling in 1905 (Talaro & Chess, 2012). Histoplasma capsulatum is a dimorphic fungus that can grow in human bodies as yeast. It is known to grow best at human body temperatures, and it remains in a mycelial form at ambient temperatures (Fayyaz, 2013). Most individuals who inhale this microscopic fungal spore don’t get infected, however some individuals who inhale this spore result in developing lung infections. H. capsulatum is a fungus that can be found in the soil, and is associated with bird and bat droppings (CDC, 2013). It is interesting that it took so long after the discovery for its epidemiology to now suggest that it has been present for as long as agriculture is practiced (Talaro & Chess, 2012). Causal Agent Histoplasma capsulatum is a microbial fungus that is mostly involved in lungs and belongs to the kingdom fungi. The main target of these inhaled spores are the lungs. By targeting the lungs the spores can cause some individuals to developing minor or severe lung infections (CDC, 2013). Histoplasmosis is an airborne infection, which is transmitted when an individual inhales the spores when disruption of soil or materials contaminated with bat or bird droppings takes place. Epidemiology Histoplasmosis disease is primarily found in the eastern and central regions of United States. Specifically, it can most commonly be found in the Ohio Valley, and other areas with moist soils that have high levels of bird and bat feces (Talaro & Chess, 2012). Since the Histoplasma capsulatum is much associated with soil and bird feces, it is very common among individuals who are working in parks, bird roosting areas, ... ... middle of paper ... ...of histoplasm's virulence factor CBP. Retrieved February 26, 2010, from http://pubs.acs.org/doi/abs/10.1021/bi701495v#fn1 CDC (2013), Histoplasmosis. http://www.cdc.gov/fungal/diseases/histoplasmosis/index.html Edwards JA & Rappleve CA. (2011). Histoplasma mechanisms of pathogenesis-one pertfolio doesn’t fit all. Retrieved 2011 by PubMed http://pubmedcentralcanada.ca/pmcc/articles/PMC3228276/ Fayyaz, J.(2013). Histoplasmosis. Retrieved 1994-2014 by WebMD: http://emedicine.medscape.com/article/299054-overview MedScape (2013). Amphotericin B. http://reference.medscape.com/drug/fungizone- amphotericin-b-conventional-amphotericin-b-deoxycholate-342582 MedScape (2013). Itraconazole. http://reference.medscape.com/drug/sporanox-omnel- itraconazole-342591#0 Talaro KP & Chess B. (2012). Foundations in Microbiology: Basic Principles. 8th edition. McGraw-Hill.

    More about Pathogen that Causes Histoplasmosis: Dr. Samuel Darling

      Open Document