Oral Precanerous Lesions are Too Common

934 Words2 Pages
bulb-icon

Recommended: Oral tumor

Oral precancerous lesions are one of the most common lesions worldwide today. They are usually neglected by the common population when compared to cancerous lesion. However, they also may be extremely fatal which changes as cancer if left untreated at a very initial stage of the lesion. Early detection and treatment gives the best chance for its cure. The detection and diagnosis are currently based on clinical examination, histopathological evaluation of the biopsy material and molecular methods. Several medications have been developed over the years for early cure of oral precancerous lesion. The purpose of this article is to review the available curcumin herbal to treat these precancerous lesions.

Key words: curcumin herbal, oral precancerous lesions, anti-oxidant, apoptosis

INTRODUCTION

Extensive research within the past half-century has indicated that curcumin (diferuloylmethane), a yellow pigment in curry powder, exhibits anti-oxidant, anti-inflammatory, and pro-apoptotic activities. The anti-pre-cancer activities assigned to curcumin are mediated through an anti-oxidant and DNA protecting mechanism1. Values for serum and salivary vitamins C and E showed a significant decrease in oral leukoplakia, submucous fibrosis and lichen planus, in contrast to healthy individuals, but increased significantly in all groups subsequent to curcumin administration after clinical cure of lesions.Oral leukoplakia and submucous fibrosis are two major precancerous lesions, but only 8-10% of these lesionsultimately become malignant2 . The ability to clinically predict malignant transformation is limited and routine histopathological diagnosis has limited prognostic value. The presence of epithelial dysplasia is an important paramete...

... middle of paper ...

...patients after intake of curcumin, as compared to pre-treatment levels1. The mechanisms by which curcumin mediates its prooxidant effects remain unclear. It has been suggested that mitochondria play a role in curcumin-induced apoptosis. It is possible that curcumin activates the mitochondrial enzymes that lead to production of reactive oxygen species (ROS) 21, 22.The induction of ROS by curcumin may occur through its interaction with thioredoxinreductase, thus altering its activity to NADPH oxidase, which could then lead to the production of ROS23.The mechanism of action of TO in oncoprevention can be speculated to be through its antioxidant action and protection against DNA damage.

An adverse effect on lipids was noticed in only one case in this study. Prakasunand et al have reported on the biochemical safety of turmeric, 3gms/day, in 54 cases of pepticulcer24

Show More
Related

  • Medicinal Industry: Serratia Marcescens

    1643 Words  | 4 Pages

    Montaner, B. and Perez-Tomas, R. 2001. Prodigiosin-induced apoptosis in human colon cancer cells. Life sciences, 68 (17), p. 2025-2036.

    Read More

  • Vitamin C By Linus Pauling

    2191 Words  | 5 Pages

    ...rious cytostatic drugs(40). It is important to note that specific dosage of vitamin C is crucial when combining it with cytostatic drugs; while Heaney used concentrations of 0-750 uM, Anja Fromberg applied 1-2 mM of vitamin C. Thus, proper dosage is seen to effect results in a positive manner, while improper dosage can have detrimental cytotoxic affects (6).

    Read More

  • The Myth behind Miscletoe

    1175 Words  | 3 Pages

    Mistletoe has been extremely beneficial to medical science throughout the ages. It has been known to help cure or relieve epilepsy, hypertension, headaches, menopausal symptoms, infertility, arthritis, and rheumatism. Mistletoe is one of the highest alternative medicine remedies for cancer. In European countries, extracts made from European mistletoe are among the most prescribed remedies for cancer patients.” (National Cancer Institute p.2) In the International Journal of Cancer, they ran multiple tests with the mistletoe extract and found that the results of the clinical testing is highly inconsistent. In fact the stronger tests found that there is no improvement in quality of life in the patient. “The search terms were alternative medicine, cancer, controlled clinical trial, Eurixor®, Helixor®, Iscador®, lectin, malignancy, Mistel, mistletoe and derivatives. In addition, manufacturers of commercial mistletoe products and other experts were asked to contribute published as well as unpublished material, and our own extensive files were hand-searched.” (Eduard Ernst,Katja Schmidt, and Miriam Katharina Steuer-Vogt p.262–267) Because of limited data on the efficiency of mistletoe, only patients with primary or secondary brain tumors, leukemia, or malignant lymphoma are treated with mistletoe extract. Mistletoe extract is not used on pregnant or nursing women, ...

    Read More

  • Skin Cancer

    1539 Words  | 4 Pages

    Skin cancer is a disease that can affect any one. Skin cancer includes many types that can be classified as severe or superficial. Consequently, treatement of skin cancer depends on the degree of severity a person has. In the following paper, we will shed lights on the types of skin cancer and its causes. Finally, we will investigate how to treat the different types of cancer and how to avoid it.

    Read More

  • Herbal Medicine Essay

    1150 Words  | 3 Pages

    ...the body. Radiation can also cause damage to normal tissue. Thus chemotherapy acts in a harmful way. Here lies the fundamental difference between the chemotherapy and herbal medicine. In chemotherapy the chemicals act on the body, causing harm to the body, actively disrupting the vital processes interfering, interrupting, impairing in a dynamic manner whereas, in contrast the body acts on herb resulting in the restorative, curative and yet passive influences of herbal medicine. The rhizomes of Sansevieria roxburghiana is reported to possess anticancer activity18,20. So far there is no bioactivity guided fractionation studies on anticancer activity of rhizomes of Sansevieria roxburghiana. Therefore, a detailed investigation of the rhizome of Sansevieria roxburghiana is needed to establish scientific data on the anticancer potential using various cell lines.

    Read More

  • Cancer

    2308 Words  | 5 Pages

    ...tantly making efforts to discover new drugs and design better protocols for this cancer. Synthetic anticancer drugs kill the cancer cells but they are also harmful to the normal cells. Since, increase in the use of these drugs in cancer therapy leads to many side effects and undesirable hazards, there is a worldwide trend to go back to natural resources, i.e., traditional plant preparations which are not only therapeutically effective but are actually acceptable and economically within the reach of even the neediest people. The present study was undertaken to understand the effectiveness of the plants against hepatocarcinogenesis. Any practical solution in combating this dreadful disease is bound to be of paramount importance. Generally speaking, integrated approach to combine western and herbal medicines to treat cancer has proved to be relatively satisfactory.

    Read More

  • Oral Pathology

    2527 Words  | 6 Pages

    -Characterized by the elongation and hyperkeratosis of the filiform papillae, resulting in this hairlike appearance. The elongated papillae usually exhibit brown, yellow, or black pigmentation. Most patients are asymptomatic, but occasionally patients complain of irritation, gagging, or an altered taste. Patients are usually heavy smokers with poor oral hygiene and some have vitamin deficiencies, GI problems, or radiation therapy. Cures range from just brushing the tongue to corticosteroid therapy.

    Read More

  • The Benefits Of Turcumin Diet

    101 Words  | 1 Pages

    Turmeric has many different heart benefits due to the active curcumin. Researchers at the University of Toronto have found out that the curcumin helps stop many different reactions in the enlargement of the heart chambers or cardiac hypertrophy. It is also believed to help stop or reduce inflammation and fibrosis. Another study was conducted in Japan and it was found that the curcumin also helps the reduction of cardiac hypertrophy by creating healthy measurements of blood pressure. Curcumin acts as an anti-inflammatory which is the cause of many different conditions. This is why turmeric makes a good heart healthy diet plan.

    Read More

  • Black Cumin Seeds as an Alternative to Chemotherapy

    792 Words  | 2 Pages

    Although chemotherapy is an effective treatment for cancer, patients still suffer from side effects such as hair loss. Thus, more studies need to be done to find alternative medications that do not have side effects. Folk medicine is one option used to treat many diseases such as hepatitis B, bacterial infection and parasitic infection (Ahmad et al., 2013). For instance, black seeds (black cumin) showed effects on cardiovascular disease because of the presence of the Thymoquinone component (Ahmad et al., 2013, Khan et al., 2011). Thymoquinone (TQ) has anti-inflammatory, anti-bacterial and anti-cancer properties (Ahmad et al., 2013). Therefore, black seeds limit the replication of the abnormal WBCs that contain the leukemia. In previous studies, derivatives of black seeds were used against myeloid leukemia (Khan et al., 2011), but this study is focusing on the effects of black seeds themselves.

    Read More

  • Loose Leaf Tea Essay

    735 Words  | 2 Pages

    It is said to bring down the danger of lethal heart sicknesses and can battle disease. Researchers are mindful of the way that the opposition to oxidants exhibit in loose green tea can battle against tumor. As indicated by late disclosure, it has been assembled that a few chemicals in green can disturb a particle that is in charge of the advancement of tumor. Green tea helps in weight reduction, supports the insusceptibility, diminishes cholesterol levels, glucose, and hypertension, counteracts tooth rot, and has different profits also. Drinking natural loose leaf tea from the high end tea brands can be useful for the wellbeing for various reasons. Research has demonstrated that the opposition to viral and hostile to bacterial operators in natural tea keeps some regular viral infections and tooth rot. It additionally helps in processing and unwinds the

    Read More

  • Determination Of Ascorbic Acid

    1336 Words  | 3 Pages

    Ascorbic acid is also called vitamin C and its antioxidant and metabolic properties are essential to both plants and animals. For instances, most of the deficiency-related diseases, like scurvy, can be healed by using ascorbic acid. Moreover, vitamin C is useful in improving human immunity system (ZHANG, 2013). One way that ascorbic acid functions to protect human health is that it can act as an antioxidant to react with the oxidants of the reactive oxygen species (ASARD, et.al., 2004). Reactive oxygen species refers to the reactive molecules containing oxygen and one of the examples is the hydroxyl radical (ZHANG, 2013). This kind of radical can cause damage to human health by interacting with proteins, lipids and nucleic acid in human’s cell (ASARD, et.al., 2004). Since ascorbic acid can react with these radicals, the resulting molecules will become stable and will not harm human’s cell anymore (ASARD, et.al., 2004).

    Read More

  • The Relationship Between Nutrition and Aging

    1450 Words  | 3 Pages

    The free radical theory predicts that decreasing the amount of free radical damage and oxidative stress in the body has positive effects on immune function, cognition, inflammation, and cardiovascular disease. Free radicals are reactive oxygen and nitrogen compounds that attack proteins, nucleic acids, and lipids altering cell and tissue function in the body. Studies have established antioxidants, phytochemicals and vitamins help the metabolism fight, reduce and prevent free radical damage delaying the rate of aging and prolonging life (1). Functional foods known to provide these benefits include Vitamin E, Vitamin C, Vitamin A, Copper, Zinc, Magnesium, phytochemicals, polyphenols, and Omega 3 fatty acids. Some food products that deliver good sources of antioxidant vitamins and minerals are green leafy vegetables, green tea, red wine, soybeans, olive oil, citr...

    Read More

  • Ayurveda

    2131 Words  | 5 Pages

    Ayurveda is the general name given to the collective practices of ancient Indian medicine and is made up of many different components such as lifestyle changes, iridology, massage therapy, aromatherapy and importantly, the application of medicinal plants and herbs. As an ancient science, until recently not much research has been conducted on the efficacy of such treatments and practices. This has been due to both the lack of availability of concrete resources and debate on the validity of translations of first sources. Of all the herbs, the use of three of the traditional plant-based treatments- namely Neem (Azardirachta indica), Sage (various Salvia species) and Turmeric (Curcuma longa) - will be discussed due to reported high efficiency rates and frequent usage. These plants are reported to be highly useful in the field of Ayurveda and are not only the most frequently listed of all the herbs but also the most frequently researched. Although many cases have been documented to prove the usefulness of these herbs, there have been many cases that discourage the practice of Ayurveda by providing an argument against the safety and reliability of these herbs. Many of these claims now have recently been verified or shown to be false through proper scientific study. The use of neem and turmeric in particular has become highly controversial due to the concepts of biopiracy and biopatents and a brief introduction of that topic will be given with specific examples. Issues of safety and the general lack of scientific study will also be discussed. Negative effects of Ayurveda and Ayurvedic remedies that have been discovered through research are presented. Other benefits of using Ayurvedic plant-remedies such as cost effectiveness will also be analyzed.

    Read More

  • Four Types Of Vegetarianism

    830 Words  | 2 Pages

    Nowadays, healthy is the number one individual and also governmental concern. As the saying goes, ‘an apple a day keeps the doctor away’ is clearly show that eat nutritious food such as fruits and vegetables can provide a good health and can prevent us from harmful diseases. As we know, vegetables provided various types of vitamins needed by the body for instance pumpkin contains a lot of vitamin A, tomatoes contain vitamin C and spinach contains folate. Pumpkin is one of nature’s riches sources of alpha-carotene, a carotenoid that converts to retinol which is a form of vitamin A. The amount of vitamin A that contain in the pumpkin per serving (116g) is 171%, vitamin C 17%, calcium 2% and iron 5% (Pumpkin raw, 2014). There are a lot of benefits when consuming vitamin A, for example this vitamin promotes healthy vision, bone growth, reproduction and help boosts our immune system. Apart from that, a diet high in vitamin A may lower the risk of many types of cancer. Besides, some vegetables also contain a lot of vitamin C such as tomatoes, bell peppers and broccoli. The function of vitamin C is it helps heal the wounds and keep away the body from bacterial infection. According to researchers at Albert Einstein College of Medicine of Yeshiva University, they discovered that vitamin C can kill drug-resistant tuberculosis (TB) bacteria (Libov, 2013, para. 3). Besides that, vitamin C

    Read More

  • Vitamin C In Citrus Fruits

    1049 Words  | 3 Pages

    In this experiment, I discovered whether cooking food destroys potential vitamin levels. In this case, I focused on vitamin C in citrus fruits(oranges). You can, however, extend the experiment by testing other vitamins and foods as well! Vitamin C is a vitamin that is needed for normal growth and development throughout your body. It helps your body heal also. Vitamin C was first used to combat a sickness called Scurvy. Scurvy was common among those with poor access to fresh fruit and vegetables, such as remote, isolated sailors and soldiers, which means no access to vital vitamins and nutrients needed for the body to stay healthy. Scientists are now researching on how high doses of vitamin C can cure cancer cells and other deadly diseases, such as lymphoma. All in all, Vitamin C is vital to our health as well as life.

    Read More

More about Oral Precanerous Lesions are Too Common

Open Document