Understanding Nucleation: Primary and Secondary Types

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nucleation. When nucleation in the liquid phase is catalyzed by foreign surfaces other than the material to be crystallized (such as by dust particles or wall surfaces), it is described as primary heterogeneous nucleation. In solutions in which crystals already exist, secondary nucleation is thought to be by far the most significant source of nuclei. The supersaturation at which secondary nucleation rises is much lower than that which gives rise to primary nucleation.( Garside and Davey ,1980; Garside, 1985; Nyvlt et al., 1985); Fig. (I.4) shown A simple scheme for nucleation . Fig.I.4. Simple Scheme for Nucleation. A. Homogeneous Nucleation As stated previously, the supersaturated solution is not in equilibrium. So, in a supersaturated …show more content…

This process is called crystal growth. On the other hand, once the nucleation step has been overcome, nuclei grow into macroscopic crystals. This stage of the crystallization process is known as crystal growth (Rodriguez et al. 1999, Hess and Kok 1996). The kinetics of crystal growth can be described by the following differential equation (Gill et al. 1984): - (dS/dt) = (dP/dt) = kASn (I.16) Where S = supersaturation, t = time, P = precipitation, k = reaction rate constant, A = surface area for crystallization, n = order of the reaction. For Calcium Oxalate, n = 2. Therefore after integration, the above equation becomes: - (1/S) = kAt - (1/S0) (I.17) where So = initial supersaturation. Therefore by keeping the surface area constant in metastable supersaturated solutions, the rate constant (k) can be derived. This can be utilized in the Langmuir adsorption isotherm to compare inhibitory activities of added substances . In whole urine, calcium oxalate crystallization can be directly measured by adding specific quantities of oxalate seed crystals and measuring changes of 14C in the supernatant fraction (Gill et al.

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