Nanotechnology and bioinformatics: The fight for cancer
Introduction
Cancer is a very complex diseases caused the damaged of genes that control the growth and separation of cells. The instructions that tell cells to function come from the genes. In order for cancer cells to grow they require blood. A molecule that looks or function like a hormone causes blood vessels that are close by to grow towards the cell to supply the oxygen and other nutrients. To cure cancer the damaging mechanism must be rectified or the blood supply that goes to the cells must be stopped or by destroying the cancer. The current prognostic and diagnostic classifications fail to reflect the clinical heterogeneity of cancer tumors and they are inadequate in making predictions for successful patient outcome and treatment. Some current anticancer agents do not show the difference between normal and cancerous cells, this creates adverse effects and systemic toxicity. Many times cancer is diagnose in its last stages and treated late, by this time the cancer has invaded and penetrated into other parts of the body.
Bioinformatics is the application of computer technology that manages the biological information. Computers are utilised to collect, keep, integrate and analyse biological and genetic information that can be used in gene-based drug development and discovery. Bioinformatics capabilities have been precipitated by the explosion of publicly available genomic data resulting from the human genome Project.
Nanotechnology is a field that many different arrays of devices developed from physics, engineering, chemistry and biology. For the targeted delivery of anticancer drugs and...
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...m transcription factor binding information, were applied for the interplay between the response to anti-cancer therapy and a cell molecular state. To help clinicians to understand the application of to PAM50 centriod-base genomic predictions for the cancer of the breast multivariate assays was used, this process characterize an error introduced in the assay results from the intrinsic error in sample preparation and measurement of the factors that helped.
Conclusion
Nanotechnology and bioinformatics play a very big role in the cure for cancer. There is still a need for new applications to help people worldwide. This new applications will have to be more advance than the ones that are available and they must bring no harm to humans. It is very important to diagnose cancer at an early stage, this could prevent many people dying.
References
It helps medics to find a direct genetic cause of the patient’s condition and target it with pharmaceutical or other therapies. The technology is used for the identification of DNA sequences that increase risks of current diseases and disorders; with this information carriers can start to make efforts to prevent them before the development of the problem. The video mentioned 200 actionable genes, structures that have direct links with a specific condition. Knowing about their presence, people have a chance to bring in preventive measures like taking anticoagulants in the case of identification of a thrombogenic gene. The technology led to the significant improvement of diagnostics and personalized treatments. It helped to find a rare, life-threatening mutation in case of Beery twins and assign a drug to a girl (Alexis) that returned her to a normal life. In the case of cancer genome sequencing led to the development of genetic drags, which target essential tumor genes and make malign structures to shrink. The video mentioned a product that works with the BRАF protein that induces cells to uncontrolled division; the drug led to the remission in the patient with metastasizing melanoma. Such treatment was effective in the case of cystic fibrosis. In the case of the breast cancer the technology helps to evaluate the aggressiveness of the condition and make a personalized decision about chemotherapy. The video also mentioned the pre-implantation genetic diagnosis – an early-staged technology that prevents the development of inherited disorders in
Over the years, surgery has made tremendous progress while changing human perspective; viewed as “no more science than butchery” a couple of centuries ago to now considered to be a solution for many health care problems threatening humans, like cancer, heart disease and kidney failure. Nevertheless, surgery has not been perfected to a level that provides successful results every time it is performed on patients. For example, surgery done to remove tumors in cancer patients result in only 45% of individuals to be cured. However, in order to be successful, the surgical procedure has to be carried out incredibly precisely and incomplete removal of tumors can decrease survival rate. Therefore, surgeons have to be able to recognize diseased tissue and distinguish it between healthy tissues. But even with the use of radioactive tracers and visuals, surgeons are not able to identify the exact site of the unhealthy tissue and its boundaries. Thus, almost 40% of the time cancerous cells are left behind because even the best qualified surgeons are not successful at the nanotechnological scale of tissue.
Amandi Hiyare: Before forming my research question, I had a discussion with my research project coordinator “Lisa Pope” who told me that the Flinders nanotechnology research team has been developing microbial catheters. Then on Monday I had an interview with Professor Joe Shapter who told me that your team was leading this project. So I was wondering whether you would be able to provide me with some detailed information about this innovation?
Cancer is a disease in which cells multiply out of control and gradually build a mass of tissue called a tumor. There has been a large amount of research dedicated to the treatment and cure of cancer. Several types of treatments have been developed. The following are just some of the major examples of cancer therapy: surgery, chemotherapy, radiation therapy, biologic therapy, biorhythms, unconventional treatments, and hyperthermia. Each type of treatment is discussed in detail below.
Cancer is the term used to describe a group of diseases consisting of hundreds of ailments and although there exists so many different types of cancer, they all begin in a similar way. The body is made up of over a trillion cells, and cancer is the uncontrolled growth of malfunctioning cells in the body (Dawson, 1996). “Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries” (American Cancer Society, 2012).
Cancer is a method by which normal cells of the body mutate and develop quickly into abnormal cells. As early as the 1880s, the only method of treatment of cancer was a radical surgery. This same method of treatment continued into the 1980s. Before chemotherapy, people were treated with comfort measures, meaning they were given drugs to help relieve the pain until they died. Also, before the 1950s, if you were admitted into a hospital with a cancer that could not be treated with surgery, it was understood you were there to die. In the beginning of the 20th century, treatment for cancer consisted of removing small cancers and those that were easily removed by surgery. Later on, radiation therapy was used to prevent the growth of those tumors that were not removed during surgery; then, chemotherapy was used to remove even smaller tumors that could not be removed by surgery or treated by radiation.
Wang, K., Wu, X., & Huang, J. (2013, February 28). Cancer stem cell theory: therapeutic implications for nanomedicine. Retrieved December 12, 2013, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589204/
Cancer in one way or another touches all of us, whether as a patient or through the diagnosis of the people you love around you. Millions of patients who are faced with cancer are depending on oncologists everywhere to cure cancer so others will not suffer like they had to. Optimistically, sooner rather than later this international problem will come to an end. There are a number of drug companies that have been coming out with cancer treatment drugs. “Oncology has been one of the hottest and most active therapeutic areas for drug development, drug makers may want to take note of a finding that new cancer drugs have proven far more difficult to gain approval than medicines for infectious and autoimmune diseases.” (nature.com) Unfortunately, these drugs cannot cure the cancer but it sure makes it a load easier o...
The purpose of this paper is to describe the diagnosis and staging of cancer, complications of cancer, the side effects of the cancer treatment, and methods to lessen the physical and psychological effects of cancer.
“Since 1990, over 6 million Americans have died of cancer, more than the combined casualties from the Civil war, WWII, and the Vietnam and Korean conflicts combined” (Faguet, p. 5). According to American Cancer Society projections, there were 1,529,560 new cases of cancer in 2010. Cancer is becoming more and more common around the world. New cancers are constantly being discovered. Researchers are finding new ways to detect cancer and treat it so that the fatality rate does not rise. However, there are some cancers that researchers have not yet discovered a cure for. It is very important for Cancer Research to continue so that one day these cancers will no longer be a treat.
Cancer is a disease that affects human somatic cells. It causes the cells to divide uncontrollably and form masses known as tumors. There are two different types of cancer tumors. Some tumors are benign and other tumors are malignant. Benign tumors look similar to the tissues that they came from and develop slowly. The tumor remains in the same area that the tumor originated in. Malignant tumors are formed from cells that do not resemble the tissue that they came from. They vary in shape and size. This enables pieces of the tumor to break off and spread to other places in the body. Over the past few decades cancer has become a very prominent disease. There are many different types of cancer and many different causes for the the disease. Most cancers are because of a genetic mutation. The most common type occur when a cell is dividing. Proto-oncogenes, which are alleles in a normal cells, mutate to form oncogenes. These oncogenes cause cancer because they do not allow the cells to self destruct or become epistatic. There have been several research projects which have been testing epistatis.
Regenerative medicine targets the conservation and development of organ function. The modification of tissues is obtained by linking living cells with materials that work as scaffolds to support cell generation. Nanotechnology is the means that feeds the material structure that simulate biological ones and additionally provide a direct delivery system. The functionality of nanotechnology for regenerative medicine is primarily due to its small unit size according to the International System of Units, one nanometer is one-billionth of a meter. The unit size allows for the technological apparatus to navigate the bloodstream and target and fix damage cells in tissues.
At the Rice University Center for Biological and Environmental Nanotechnology (CBEN) they were stunned to discover that there had been no research in developing a risk assessment or toxicology model for synthetic nanomaterials. Like-wise and...
I have chosen nanotechnology as my topic area of choice from the food innovation module.
The most interesting part of this career is developing nanotechnology. They may cure diseases or slow the aging progress. Most nano-devices are as small as 100 nanometers across so, they are built on the atomic scale. If put into the human body and designed pro...