Myocardial Infarction And Heart Disease

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HEART: Disease: Heart diseases are a leading cause of death throughout the world. Myocardial infarction with serious damage to the left ventricular function continues to affect many people, causing morbidity and mortality (Weber et al. 2013). Valvuar heart disease also affects many people with a condition called valvular stenosis; where the tissues in the valves become stiffer and fail to open properly. This results in the valve opening to become narrow and cause the blood flow to lessen due to not being able to flow thoroughly. As a result, the body may not receive accurate blood flow. Myocardial infarction is the death of the cells in an area of the myocardium. This causes oxygen deficiency, which is a result of a block in the blood supply also known as a heart attack. The left ventricle is the chamber of the heart that conducts most of the work. It is also the most usual site for myocardial infarction. Fibrotic scar formation and eternal impaired cardiac function is the result of the lack of blood movement in the ventricle (Zammaretti 2004). Tissue changes in the myocardium are associated with how much the cells have been deprived of oxygen. As a result, the tissues of the heart become dead and lack its regenerative capability. Research and treatment: Advances in tissue regeneration may help these diseases with cardiac tissue engineering, which aims to provide contractile heart muscles constructs for replacement therapy (Zimmermann et al. 2004). Synthetic, biological matrixes and heart cells are used to reconstruct contractile cardiac muscle-like tissue. This may be used for the replacement of a diseased myocardium. The cardiac tissue construct should imitate an actual heart muscle, show functional and morphological prop... ... middle of paper ... ...(Gemerling et al. 2013). Zebrafish are a highly useful study due to the availability of genetic tools and strong regenerative capacity (Major et al. 2007). Cardiac progenitor cells are studied to be successful in heart regeneration with the zebrafish and can be used to help tissue regeneration in humans. Future Research: Additional studies in the future will help increase the aim of regenerative direction of tissue in humans. With the study of the zebrafish, possible factors can be used and the full potential of emerging technologies will strengthen the foundation of regeneration studies. The advances in gene targeting, chemical screening and visualization techniques in the zebrafish can help make new discoveries. (Gemerling et al. 2013). These studies and experiments may help create new techniques to help and prevent heart disease.
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