In 1984, Caeser Milstein of England and George Kohler of Switzerland were awarded Nobel Prize for engineering ‘monoclonal antibodies’. These are made outside the body by the fusion of B-cell and myeloma cells (cancerous cells). These hybrid cells are known as hybridomas.
For the production of the monoclonal antibodies, B-cells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B-cell are then fused with myeloma tumor cells that can grow indefinitely in cultures (myeloma is B-cell cancer). This fusion is performed by making the cell membranes more permeable. The fused hybrid cells, being ous cancer oils cells, will multiply rapidly, as a result, large amounts of the desired antibodies will be
A 54 year old female was presented with complaints of lethargy, excessive thirst and diminished appetite. Given the fact that these symptoms are very broad and could be the underlying cause of various diseases, the physician decided to order a urinalysis by cystoscope; a comprehensive diagnostic chemistry panel; and a CBC with differential, to acquire a better understanding on his patient health status. The following abnormal results caught the physician’s attention:
I have chosen to write about the constellation Cancer (The Crab). I chose Cancer because it is one of only a handful of constellations that I am actually able to identify in the night sky. Cancer is one of the twelve Zodiac constellations; people whose birthdays fall between June 21st and July 22nd have Cancer as their sign. Cancer is the Latin word for crab, and despite the fact that the constellation looks more like a lobster then a crab, it is still referred to as a crab. The constellation is visible from the northern hemisphere from late winter to early spring.
Over one million Americans in the United States are living with or have been diagnosed with leukemia. That’s a big amount of people. I chose to do my research paper on leukemia because two years ago I lost my grandma to the cancer. I wanted to know more about the disease and what was happening to her. I researched the different types, risk factors, symptoms, treatment, and what kind of research is being done to help cure leukemia. Leukemia is a cancer of the blood cells that start in the bone marrow. During leukemia the bone marrow starts to make a lot of abnormal white blood cells or “leukemia cells”.
Melanoma is the most serious form of skin cancer. It’s produced in cells called melanocytes which produce pigment in your skin. Melanoma can be formed or resemble a mole. It can also be caused from too much sun exposure that you can acquire from tanning beds. If melanoma is diagnosed and treated at an early stage, it can almost always be cured. But if it’s not, the cancer can advance and spread throughout the body where it can be hard to treat and be fatal. I witnessed one of my friend’s,mother fight first hand. I was in 3rd grade, she was diagnosed with stage 4 melanoma. With being so young, it was hard for my friend to understand the possibilities of the dangerous cancer. She fought for two hard and exhausting years. The doctors did the best
Holder, W.T., McCord, D.L., and Turner, Ralph J. 1984. Isoimmunization with Anti-U Antibody. Journal of the National Medical Association. V.76 (3). Pg. 277-283.
Over the past years, stem cell research has been very famous through the scientific community and the media. Stem cells are pluripotent cells that are present in every single organism on Earth. The power of stem cells are beyond imagination. Stem cells have the power to turn into any type of cells. Some examples are, blood cells, nerves, cardiac muscles, and the list goes on and on. The scientific community has recently taken a large interest in stem cells. They have used stem cells to treat horrible misfortunes that people have been diagnosed with. Some examples of the diseases that are being treated by the use of stem cells are, Alzheimer’s, Parkinson’s, spinal cord issues, strokes, diabetes, damaged organs, and even cancer! However, despite the infinite potential for medical treatments, the topic of stem cells is surrounded by enormous amounts of controversy. The questions that feed the controversy are about how the stem cells are acquired and about how the gained knowledge would be used. However, it is necessary for mankind to keep stem cell research alive in order to save lives while taking care of any unethical topics about it.
The Phase I trial will be discussed here as it pertains to the topic at hand. The typical treatment for cervical cancer if surgery is not a viable option – like if the cancer has spread, then called locally advanced cervical cancer – is chemotherapy and radiation treatment at the same time. This phase I clinical trial is simply looking to add ipilimumab to this regimen, but once the chemo/radiation has been completed (LACC article). Chemo and radiation destroy tumor cells, which causes tumor-associated antigens to be released. Once released, these antigens are exogenous (outside the cell) and will be presented to helper T cells to initiate an immune response.
In the 1960s the HeLa cells were everywhere. In the 1960s the scientist wondered since the cells grew so fast and lived on earth so well if they would live in space. They got the idea to send the Hela cells to space. They sent several vials into space by the Discoverer XVII when it went. They discovered that when the HeLa cells went to space they became more powerful and divided faster every time they went to space. Several years later in 1965 they took equal amounts from the HeLa cells and cells from a mouse. The scientists done this to study to see what the genes would do. Harris also took HeLa cells and chicken cells, but they discovered they couldn’t reproduce.
I believe my thesis statement is argumentative because, not all States allow for a patient to choose what form of drug they can use to relieve pain, nausea, sleep and eating problems while on Chemo and Radiation therapy. There are many studies that have prove how the use of smoking or vaporized (inhale) have help Cancer patients have a more enjoyable
What is Leukemia? Leukemia is a cancer in blood forming cells that are in early stages of development. Most of the time the white blood cells, but some types of leukemia start in other types of blood cells. Blood cells are form in bone marrow. Any of these cells can turn into a leukemia cell, once this happens the cell does not mature like it should. The cell may start to produce rapidly and the mutated cells probably won’t go through apoptosis like they should. These cells build up in the bone marrow and crowd out the healthy cells. Typically, leukemia cells get into the blood stream rather quickly. From the blood stream they can spread to places like lymph nodes, spleen, liver, central nervous system or other organs where the leukemia cells can cause those other cells to function irregularly.
Cancer has become leading cause of death across world in the class of non-communicable diseases. This has led to massive research in cancer diagnosis and prognosis. Diagnosis of cancer in early stages could prevent its spread to other organs of the body and possible cure of the patient. More and more different types of cancers are being identified and mostly they have to be treated differently. Cancer classification plays a very important role in cancer diagnosis. Earlier strategies used for cancer classification: morphological and clinical had some limitations. They were not able to predict cancer subtypes accurately. It has been identified that giving treatment according to the tumor type is more effective for the patients. Tumors of a particular type of cancer differ at the molecular level, i.e. the genetic level.
IgG is the uncontrolled production of abnormal immunoglobulin (IgG) proteins, which fight bacteria and viruses. This abnormal immunoglobulin has no benefit in the body, and, as it increases in amount, it crowds out normally functioning immunoglobulins. This is the most common types of myeloma, accounting for 60-70% of all cases.
...ifiable in any patient with the disease, and provides special information associated with staging or anatomic disease extent. The other attribute that make the antigen an ideal tumor cell maker include the fact that it permits for earlier identification of treatment failure resulting in early salvage treatment.
Immune-staining with an antibody is done by binding the antibody to a specific antigen. This is carried out by adding a staining fluorescent dye to a thin section of a tissue or cell. A secondary antibody is coupled to a fluorescent marker (1) that can attached to the primary antibody and increase the light signal. Hence, increase visibility.
The agglutination principle is commonly used by serological quantitative assay to quantify unknown antigen or antibodies in a biological fluid. As all the Antibody isotypes are divalent or polyvalent, one antibody can bind to several antigens which will form chain linkage and clumping of antigen, giving rise to a lattice formation (antigen and antibodies complex). The lattice structure form by clumping of antigens and antibodies is process call agglutination. There are two types of agglutination reaction which are direct and indirect reaction. (jacquelin, 2002) The direct reaction is the binding of antibodies with the antigen intrinsically found on the particle’s surface and the indirect reaction is the binding of antigens with antibodies which are coated on particles (latex beads). (parija, 2009) Haem agglutination test is a specific form of agglutination test that involves red blood cells. This haem agglutination test is divided into active and passive groups, which