Multiple Myeloma Essay

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Embryonic development is a remarkable process that requires carefully regulated cell proliferation, the formation of distinct cell lineases that adopt unique cell functions, and finally the concerted interaction between cell types to produce complex tissues. These events take place within the uterus of the mother after the conceptus implants, this feature demands that the conceptus composes additional events, beyond its own development, related to controlling maternal physiological functions, growth of uterus and provision of a supply of nutrients and oxygen through the formation of the placenta; these processes are amongst the earliest events to occur during embryogenesis. The following discussion paper will give a brief description of the multiple myeloma. It will then discuss about the history of thalidomide, its pathogenesis, usefulness and side effects on embryo and foetal development. Also, it will discuss about the factors affecting teratogenicity, diagnosis process to detect any defect on unborn baby and general recommendation to the patient.

Multiple myeloma
Multiple myeloma is a clonal disease characterised by neoplastic transformation, proliferation and accumulation of plasma cells in the bone marrow. Normally, plasma cells, develops from B-lymphocytes (also known as B cells), which are a major class of white blood cells, are responsible for producing antibodies that helps to encounter foreign bodies or infections. In multiple myeloma, however, plasma cells start to multiply abnormally within the bone marrow and release immunoglobulin excessively into the bones and blood, which cause several organs damage in the body systems. It is true that the co-occurrence of multiple myeloma and pregnancy remains relatively rare, g...

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..., it is necessary to describe them in detail to the patient and to give a prognosis, as far as available medical knowledge will allow, regarding the outcome of pregnancy and postnatal development. To assist the patient in making a decision on the disposition of the pregnancy, prognostication should include medically documented risk figures. Ethically, pregnancy termination should not be recommended made to the patient and her family and significant others. This option should be discussed, but the ultimate decision of whether to continue the pregnancy should be left to the patient and her family and significant others. Furthermore, I think, it is better to refer her to the teratogen or genetic counselor to help her by providing the patient with as much information as possible and encourage her to make her own decision regarding whether to continue the pregnancy.

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