Mitochondrial Complex I Role in Cell Metastatic Properties
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Mitochondria occupy a significant amount of space in a typical eukaryotic cell, and this organism has proved to play a vital role in the evolution of human species. This organelle is considered as a powerhouse of the cell as it converts oxygen and nutrients into Adenosine Triphosphate (ATP). In complex animals, like humans, mitochondria facilitate cells to generate 15 times more ATP than they could otherwise in order to provide the vast amount of energy needed to survive. “In addition, mitochondria also perform essential functions in the regulation of cell death, cell signaling, innate immunity and autophagy through key signaling mediators such as reactive oxygen species (ROS) (Xuelian He, 2013)”. According to these critical roles, even the smallest defects can result in a number of human disorders.
Mitochondria are unique organelles, as they are the main site of oxygen metabolism, accounting for approximately 85–90% of the oxygen consumed by the cell. Incomplete processing of oxygen and/or release of free electrons results in the production of oxygen radicals. Electron transport chain, found in the inner mitochondrial membrane, contains all the essential enzymes for the proper functioning of mitochondria in respiration. This chain contains five multi sub-unit complexes (I-V) that stimulate the process called oxidative phosphorylation, for cell respiration. Complex I is considered as the largest and most least understood component of the mitochondrial system and this research goes on further to explain how the suppression of this complex can influence the human health. Basic properties of Complex I apply to both eukaryotic and prokaryotic cells. In addition, bacterial complexes have the advantage of genetically modifying themse...
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...omplex suppression can lead to invasive cell properties hence, promoting an active effect on metastasis. Although the Complex I still hasn’t been studied properly but it is likely to assist the elucidation of formation of tumors.
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Verkhovskaya Marina, Bloch A. Dmitry, 2013. Energy-converting respiratory Complex I: On the way to the molecular mechanism of the proton pump. The International Journal of Biochemistry & Cell Biology. [Primary literature, journal paper]
Xuelian He, Aifen Zhou, Hao Lu, Yong Chen, Peiwei Zhao,
Xin Yue, Yanxiang Wu, Guochang Huang, 2013. Suppression of Mitochondrial Complex I Influences Cell Metastatic Properties. DOI: 10.1371/journal.pone.0061677 [Primary literature, journal paper]