The stories setting takes place in Western Colorado. In Western Colorado in a home of a retired nurse named Annie is where the whole story takes place. Annie's home is a two story log cabin out in the middle of nowhere. The closest neighbors are miles away. It takes place in the middle of winter snow storms.
The story is about Paul Sheldon who is the author of a best-selling series of romance novels featuring its popular character Misery Chastain. Since 1974, he has finished the first drafts of all his books in the Silver Creek Lodge in Colorado. Finishing his new novel, Fast Cars' he drives to L.A. unaware that the Western Slope of Colorado is going to be hit with one of the biggest snowstorms of the year in a few hours. Determined to drive through this, he loses control of his car, and drives off the road, tumbling down the steep hill and falling unconscious.
Paul is rescued from the car wreck by a woman named Annie Wilkes, an experienced nurse who lives nearby. As Paul waves in and out of consciousness, he hears a voice telling him that she's his "number one fan". Annie takes him not to a hospital, but to her home, putting him in a spare bedroom. As Paul regains consciousness, he lies there completely helpless, being unable to move anything from his waist down. She feeds and bathes him and splints his broken legs, giving him
Novril for his pain. Paul comes to like Annie; even letting her read his new manuscript. Annie doesn't like it.
It's around this time that Misery's Child, the latest and final book starring Misery Chastain, hits the shelves.