Microglia Essay

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Microglia is an endogenous immunohomeostatic neuronal support cells in the Central nervous system (CNS) (Kettenmann et al., 2011). Microglial cells are responsible for surveying brain and spinal cord (invertebrates and vertebrates), in protection from pathogens and injury, phagocytosis, and cytotoxicity and immune homeostasis (Garden and Moller, 2006). Microglia’s homeostatic function achieves profound salubrious therapeutic state corollary for prophylaxis of neurological health in the central nervous system (Garden and Moller, 2006). Microglia with astrocyte biochemically maintains endothelial cells that creates blood-brain barrier, through this, pathogenic infection are unable to reach vulnerable nervous tissues (Dissing-Olesen et al., 2007). Furthermore, corollary on specification of homeostasis in immunological functions are based on their site and existing paradigm, and some of Microglial cells immensely depends on the level of plasticity in order to reach the standard of capability of immunity (Gehrmann et al., 1995). There are different forms of microglial cells based on their existing sites. In the perinatal white matter area, specifically in corpus callosum, microglial cells forms “Amoeboid” (Gehrmann J et al., 1995). In addition, this form allows microglial to change its location freely, all over the neural tissue (Gehrmann et al., 1995). There is also a form specified from its stationary, and this called “ramified”, only its outlets surveying the throughout the brain and spinal cord (Aloisi, 2001). This ramified is also known for its sensitivity in physiological changes (Aloisi, 2001). Furthermore, activated microglia are included to types of microglia that have two parts, non-phagocytic & phagocytic. This is the type ... ... middle of paper ... ...areas, and creation of gitter cells (Gehrmann et al., 1995). Moreover, considering the importance of microglial, without microglial cells, the CNS will not survive (mortality) from external environment substance and pathogens. Thirdly, microglial cells are also responsible for homeostasis, negative and positive feedback loop, in CNS (Aloisi, 2001). Microglia is known for achieving complex communication via triggering signals molecules with other astrocytes, neural tissues, T lymphocytes and hematopoietic stem cells (Aloisi, 2001). In conclusion, microglial cells are responsible for immune system and homeostasis in Central nervous system. Microglial cells has different function in diverse locations. It has the ability to protect CNS from pathogens that will cause neuroinflammation, and regenerate impaired tissues with synaptic stripping, & production of astrocytes.

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