Methicillin-Resistant Staphylococcus Aureus

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Staphylococcus aureus (S. aureus) is a considered both a Gram-positive bacterium and a pathogen, and is capable of causing many human diseases (Gordon & Lowy, 2008; Deurenberg, Vink, Kalenic, Friedrich, Bruggeman & Stobberingh, 2006). S. aureus is one of the most common causes of soft-tissue and skin infections (SSTIs) (Hansra & Shinkai, 2011). It can also cause post-operative infections at the wounds site, necrotizing pneumonia, and bacteraemia (Deurenberg et al., 2006). Resistance to methicillin is one of the major subtypes of this bacterium. It is then called methicillin-resistant Staphylococcus aureus (MRSA) (Hansra & Shinkai, 2011). MRSA is usually considered to be a nosocomial infection (Witte, 2009), which means that it came from the hospital environment. The mecA gene determines methicillin resistance (Gordon & Lowy, 2008). mecA encodes the 78-kDa penicillin-binding protein (PBP) 2a (Deurenberg et al., 2006). β-lactam antibiotics normally bind to the PBPs in the cell wall (Deurengerg et al., 2006). This causes the disruption of synthesis of the peptidoglycan layer and eventually the death of the bacterium (Deurenberg et al., 2006). Because β-lactam cannot bind to PBP2a, synthesis of the cell wall and peptidoglycan layer are able to continue (Deurenberg et al., 2006), and the bacterium does not die.
This paper focuses on a client who developed MRSA while hospitalized. The purpose of this paper is to explain signs and symptoms, risk factors, laboratory and diagnostic tests that were used, dietary and nutritional implications, and the pharmacologic treatment of MRSA.
Signs and Symptoms
MRSA is most commonly found in the anterior nares, and one-quarter to one-third of the population is carrying MRSA at anytime (Miller & Die...

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