Meridia: The New Anti- Obesity Drug
Introduction
In today’s society the hegemonic belief surrounding weight is that thin is in and fat is out. With over half of the American population being overweight, the diet craze has swept the nation. However, a bigger player has come into the weight loss scene, the pharmaceutical industry. After the abrupt withdrawal of two anti- obesity drugs from the market in 1997, the pharmaceutical industry has been looking to fill the void in this area of the market. Meridia (sibutramine hydrochloric monohydrate), manufactured by Knoll Pharmaceutical Co, enters with caution what now appears to be a virtually deserted and uncertain anti- obesity market. The drug works to suppress appetite via serotonin (and norepinephrine) re-uptake inhibition.
How Does Meridia Work?
In the fall of 1997, fenfluramine (the fen half of the popular fen-phen drug combination) and Redux (dexfenfluramine) were recalled after the drugs were linked to potentially fatal heart valve abnormalities. In November of 1997, only a few months after the withdrawal of fenfluramine and Redux, the Federal Drug Administration (FDA) approved Meridia. Meridia is a class of drug known as monoamine (serotonin and norepinephrine) re-uptake inhibitors. It falls in the same class of many anti- depressants such as Prozac. Serotonin is a chemical released in the brain after you have eaten a meal, which makes you feel full. When a nerve impulse reaches the end of the nerve (the nerve terminal), the impulse causes the release of chemicals called neurotransmitters. The neurotransmitters are released in the space between the two adjacent neurons, this region is called the synaptic cleft. Usually once the neurotransmitters have bound to their receptors (the neurotransmitter and the receptor fit like a lock and a key) on the adjacent nerve, transport proteins work to reabsorb the extra neurotransmitter back into the nerve terminal so that they can be reused. However, Meridia acts to inhibit the reabsorption of serotonin so the that signal lasts longer, thus giving the sensation that you are full for a longer period of time. This method is thought to effectively reduce the caloric intake of an obese individual due to appetite suppression. For an informational video on the mechanism of action for Meridia visit the world wide web at www.4meridia.com/hcprof/fma.htm.
How is Meridia Different from the Recalled Drugs?
Time and rules have been transforming countries in many ways; especially, in the 1850’s and the 1920’s, when liberals were firmly in control across Latin American region. Liberalism can be defined as a dominant political philosophy in which almost every Latin American country was affected. A sense of progress over tradition, reason over faith, and free market over government control. Although each country was different, all liberals pursued similar policies. They emphasize on legal equality for all citizens, progress, free trade, anti-slavery, and removing power from church. Liberals declared promising changes for Latin American’s future. But Latin America had a stronger hierarchical society with more labor systems, nothing compare to the United States societies. Liberals weren’t good for Latin America. What I mean by “good” is the creation of a turning point or some type of contribution towards success. I define “good” as beneficial or helpful. The Latin American economy was stagnant between 1820 and 1850 because of independence wars, transportation and the recreation of facilities. I describe this era as, “the era when Latin America when off road”.
At the turn of the century there was a new law named “Capture” therefore; whoever produced the oil owned the oil. If you did not produce the oil then somebody else would be willing to produce the oil. The consequences if the production of the well ran dried out weight the reward. “Oilmen were not the only ones who knew that production was often short-lived; bankers quickly learned that no prudent lenders extended a loan on the basis of oil production. “ It was a reality that oil production started of strong and quickly dropped off within a matter of a couple months. The risk was not worth the reward for either party which is the bakers or the oilmen. The ferocious cycles from boom to bust, from having more than enough oil to not enough would swing the price for oil up and down like a roll coaster. When a new oil field came in, the local markets hand more than enough oil, pushing the prices lower, making oil more affordable. However, whenever the oil production dropped it would send the prices sky rocketing making it unprofitable to stay in business. Pattillo Higgins would be willing to take on this challenge head on of producing oil. [Who is Higgins, Ernest? By giving at least a short introduction the readers w...
Obesity is a rising problem in the United States. With obesity rates on the rise something must be done to prevent this massive issue. There are ways to help including educating at young ages, improving nutrition facts at restaurants, and providing more space for citizens to get physically active.
Texas has prospered with many business such as through the cattle, cotton, and technology industry to keep the economy on top. One business in particular has set Texas economy a part from all the other businesses. The oil and gas industry has significantly changed Texas economy from the first discovery in the twentieth century until this exact moment.
Zamora, A. (2014). Scienitfic Psychic. Retrieved from Ghosts and Spirits in Folklore and Religion: http://www.scientificpsychic.com/esp/ghosts-spirits.html
The political power has had enormous affect to the Latin American economy. Most of the countries in the Latin America remained colonies for over a long period of time; therefore, they were controlled by the Europeans power. These colonies never thought of development of the Latin American countries, rather all wealth from the colonies was taken out to the home country. This situation is similar to other colonized continents such as Asia and Africa. Almost every colonized country in the world is still in the process of development. These countries were never benefited economically from the colonizers. Therefore, the historic imperialism is still harming countries in the Latin America as well as they are still underdeveloped. According to Marxist theory “The colonies were used as places to invest surplus capital and sell goods from the colonizing countries and as sources of cheap raw materials and cheap labor.”(P165) Therefore, the investors will always get high benefits from their investment; however, the raw materials will get low prices for it. Hence, still Latin American countries face various problems due to the excessive use of natural resources and due to late from the Europeans
In the early nineteenth century, Latin American countries started to make new reforms during the Great Depression. The Great Depression was during 1929-1939. It was the deepest and longest-lasting economic downturn in the history of the Western industrialized world. America’s Good Neighbor Policy protected Latin America from the USA controlling the businesses in Latin America in 1933. Once the U.S. left Latin America, its countries started to industrialized and become less dependent on other countries. By the 1930s, the liberal governments began to show failure. The middle class had forged alliances with elites and the military rather than expressing individual democratic beliefs as was done in the West. Although the Great Depression could
They evolved into 2 different species by many factors in nature. The factors include genetic drift, mutation, natural selection, and etc. Genetic drift involves the bottleneck effect and the founder effect. I hypothesize that a bottleneck effect took place in the island that the rodents were living in. A natural disaster must of happened and the rodents that had high fitness survived. Therefore since one population survived, that makes them two separate species. I also hypothesize that there was a founder effect in the population of the rodents. A small portion of rodents migrated to Nevis island and reproduced. When this happened this created a whole new population of rodents. Another reason that they could have been 2 different species can be due to gene flow. Some rodents could of migrated to Nevis island.
...t al. "Paranormal Encounters as Eyewitness Phenomena: Psychological Determinants of Atypical Perceptual Interpretations." Current Psychology 29.4 (2010): 320-327. Academic Search Premier. Web. 5 Dec. 2013.
A robot-assisted surgery demonstrates how far America and the whole world have come in means of technology within a particular working field. The necessity for a more superior technology within hospital settings are best supported by the development of the da Vinci Surgical System. In 1991, when the surgical system was introduced to the globe, many acknowledged that this system improved three different aspects of regular laparoscopic surgery: it gave doctor...
That our perception of the world is predominantly governed by the senses of sight, sound, taste, touch, and smell is not disputed. However, scientists and amateur academics alike have historically disagreed about the existence of any additional senses, with the most contentious debate surrounding the phenomenon generally referred to as ESP, or "psi." Despite the vast number of people who claim to have or to have witnessed psychic abilities, the corresponding research has found little that is empirically valid or significant to corroborate the wealth of more anecdotal evidence. To establish their validity, it would be necessary to show how they occur in the sensory system - how the input is received and how the subsequent outputs are generated - and so far there is no evidence for the presence of a mechanism specified for this task. Regardless of the extent to which skeptics can take their argument, that so many people over time have reported some degree of extrasensory perception somewhat justifies an inquiry into its history as a cultural and scientific phenomenon as well as any potential empirical proof.
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“In the 1840s, a new generation of politicians emerged, challenging the persons and policies of those who had held power since the end of the 1820s” (Safford, 67). It was a political change in Latin America because before there were only caudillos that only filled the political role in a country and those caudillos still acted like the kings during the colonial period. With new liberals that challenged the norms at the time period led to radical changes, such in Mexico. Since the caudillos didn’t do much that was different that their former colonist rulers. After the Wars of Independence, caudillos came into power because of the liberalism failure to get away from the colonialism legacy. Many of these caudillos took advantage of the failure of these changes that were promised by liberals. Caudillos such as Jose Manuel de Rosas from Argentina took control over the country and caused many problems between the people. Even though Rosas brought order in Argentina, he failed because of the strict leadership and may people feared off until he left in exile to England in 1852. That is one of the differences is that caudillos were the leaders that still follow the colonialism legacy, while the new liberals in the 1840s were the ones that actually
Trait theory is the idea that an individual’s personality is made up by many traits or characteristics that cause the individual to behave in one manner or another. One can easily see how curiosity fits into the trait theory. It is almost unanimously agreed upon that it is in fact a trait and is the motivator for countless actions people make every day.
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