Malaria: A Leading Cause of Death and Disease Worldwide

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An Infectious Disease

Malaria is an infectious disease caused by parasitic protozoan pathogens. There are five pathogens spread by female mosquitos of the genus Anopheles. They are the Plasmodium falciparum, found in Africa, the Plasmodium vivax, found in Asia and South America, the Plasmodium ovale, found in West Africa, the Plasmodium malariae, found in Africa and the Plasmodium knowlesi, found in South East Asia.

Humans can become the host of any of these pathogens which cause malaria through several different ways, the most common being that someone is infected through the bite of an infected female Anopheles mosquito. The parasite is injected in the mosquito’s saliva and travels to the liver, where it undergoes multiple cell divisions. It then flows into the bloodstream where it infects red blood cells and eventually body cells, which burst open and spread the parasite through the body.

Other causes include IV drug users sharing needles with someone who is infected, babies developing malaria when born to mothers who were unaware they were infected, and through blood transfusions or organ transplants.

Symptoms of malaria include a fever, headaches, nausea, diarrhoea, chills, shivering, excessive sweating, convulsions, and the loss of blood, brain damage, and coma. Those infected with malaria may also suffer from anaemia and its symptoms; fatigue, pale skin, weakness, tiring easily, low blood pressure, heart palpitations, difficulties concentrating, loss of appetite and a cracked or reddened tongue.

P. falciparum is the most dangerous form of malaria found in humans, and it has the highest rates of complications and mortality. It can lead to include jaundice, coagulation defects, spleen rupture, anaemia, shock,...

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...sion, producing thousands of active haploid forms called sporozoites, which can be injected into another human through a bite. The life cycle of the malaria parasite repeats itself.

Malaria is a leading cause of death and disease worldwide, with approximately 300-500 million cases per year reported and 1 million deaths annually. However, it can be cured by the use of prescription medication. The type of medication and the length of treatment depends on a variety of factors, such as the person’s age, where they were infected, the type of malaria, pregnancy and severity. A cure is most like to be successful for someone who is diagnosed early on in the illness.

Medications that can be prescribed to aid in the treatment malaria are Chloroquine, Mefloquine, Atovaquone-proguanil, Sulfadoxine-pyrimethamine, Quinine, Doxycycline and Artemisin derivatives.

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