Jonas Salk was born in New York City. His parents were Russian-Jewish immigrants who, although they themselves lacked formal education, were determined to see their children succeed, and encouraged them to study hard. Jonas Salk was the first member of his family to go to college. He entered the City College of New York intending to study law, but soon became intrigued by medical science. While attending medical school at New York University, Salk was invited to spend a year researching influenza. The virus that causes flu had only recently been discovered and the young Salk was eager to learn if the virus could be deprived of its ability to infect, while still giving immunity to the illness. Salk succeeded in this attempt, which became the basis of his later work on polio. After completing medical school and his internship, Salk returned to the study of influenza, the flu virus. World War II had begun, and public health experts feared a replay of the flu epidemic that had killed millions in the wake of the First World War. The development of vaccines controlled the spread of flu after the war and the epidemic of 1919 did not recur.
In 1947, Salk accepted an appointment to the University Of Pittsburgh Medical School. While working there, with the National Foundation for Infantile Paralysis, Salk saw an opportunity to develop a vaccine against polio, and devoted himself to this work for the next eight years. In 1955 Salk's years of research paid off. Human trials of the polio vaccine effectively protected the subject from the polio virus. When news of the discovery was made public on April 12, 1955, Salk was hailed as a miracle worker. He further endeared himself to the public by refusing to patent the vaccine. He had no desire to profit personally from the discovery, but merely wished to see the vaccine disseminated as widely as possible.
Salk's vaccine was composed of "killed" polio virus, which retained the ability to immunize without running the risk of infecting the patient. A few years later, a vaccine made from live polio virus was developed, which could be administered orally, while Salk's vaccine required injection. Further, there was some evidence that the "killed" vaccine failed to completely immunize the patient. In the U.S., public health authorities elected to distribute the "live" oral vaccine instead of Salk's. Tragically, the preparation of live virus infected some patients with the disease, rather than immunizing them.
At first polio was a troubling prospect when it first reared its ugly head in the United States of America. In a noble effort to be rid of polio, America as a whole was to adopt stringent sanitation measures. Everywhere, especially the home was to be spotless and clean in order to try and prevent the contraction of polio. This coupled with the view that America as a western nation seemed impervious to such a lowly disease tried to assuage American fear of the disease. Despite the measures commonly adopted throughout the myriad of cities and towns, polio still managed to spread around the country and wreak havoc taking thousands of lives. An outbreak that ravaged America claimed nearly 27,000 lives in a terrible reckoning before it finally subsided. This and several other troubling outbreaks
The authors used a historical timeline to introduce a need. Stressing the number of lives lost allows the authors show the importance of vaccines. The repeated emphasis on those lives being the lives of children played on the emotions of readers. Once the need is established Lee and Carson-Dewitt clarify the use of “a dead or mild form of a virus” to create a vaccine (Lee, Carson-Dewitt, 2016, p.2). The distinction of the types of
David Belasco was born in San Fransisco, California, on July 25,1853. Hisparents had come to California from London in the gold rush. Belasco grew upin San Fransisco and Victoria, British Columbia. His early education in a RomanCatholic monastery influenced his simple mode of dress and helped earn him the nickname Bishop of Broadway. He had some experience as a child actor, and from 1873 to 1879 worked in a number of San Fransisco theaters as everything from call boy and script copier to actor, stage manager, and playwright. He paid further theatrical dues in the time he spent as a "theatrical vagabond" (Belasco's term), acting in small theatrical companies trouping through the mining camps and frontier settlements of the Pacific Slope. He recited poetry, sang, danced, painted and built scenery, and played everything from Hamlet to Fagin in Oliver Twist and Topsy in Uncle Tom's Cabin. In 1879, with James A. Herne, his first important collaborator, he wrote the popular melodrama Hearts of Oak.
The death rate was on the decline and life expectancy rose during this period. New medical developments were made with the federal funding of medical research in which penicillin and streptomycin were developed. These advancements in medicine have cured many bacterial infections and severe illnesses. Later, in 1952, Jonas Salk introduced a polio vaccine. There was a vast migratory pattern among many Americans during this time period.
Jerzy Kosinski was born in Poland in 1933 to Russian parents who had fled the revolution. He was separated from his family when the Nazis invaded in 1939. For six years he wandered form village to village scorned by East European gypsies who feared his hawk like face and penetrating eyes. He survived German terror by his wits and he was struck dumb from the shock that he underwent from this six-year period of wandering. He was mute from age nine to fourteen.(New Yorker)
Vaccines have been used to prevent diseases for centuries, and have saved countless lives of children and adults. The smallpox vaccine was invented as early as 1796, and since then the use of vaccines has continued to protect us from countless life threatening diseases such as polio, measles, and pertussis. The Center for Disease Control and Prevention (2010) assures that vaccines are extensively tested by scientist to make sure they are effective and safe, and must receive the approval of the Food and Drug Administration before being used. “Perhaps the greatest success story in public health is the reduction of infectious diseases due to the use of vaccines” (CDC, 2010). Routine immunization has eliminated smallpox from the globe and led to the near removal of wild polio virus. Vaccines have reduced some preventable infectious diseases to an all-time low, and now few people experience the devastating effects of measles, pertussis, and other illnesses.
During the 20th century, one of the greatest medical innovations was achieved, which was the vaccine. The vaccine used various chemicals and biological substances as a way of preparing the immune system for some sort of future infection, particularly by a virus, which are more difficult to treat than bacteria. However, since the time of its use, vaccines have been under constant scrutiny, especially when some of them were mandated by the government for entry into school. Nevertheless, even though some disagree with the policy of mandatory vaccinations, these vaccines are an ethical way of ensuring the safety of individuals.
The Influenza Pandemic of 1918-1919 occurred during the midst of World War I, and it would claim more lives than the war itself. The disease erupted suddenly without a forewarning and spread rapidly across the globe. It seemed as though all of humanity had fallen under the mercy of this deadly illness. Influenza had very clear symptoms as described by William Collier in his letter to The Lancet. After a patient seizes their temperature can run up to 105° or more while their pulse averages at about 90 beats per minute. The high temperature and low pulse are frequently combined with epistaxis (nosebleed) and cyanosis (blueness of the skin). The epistaxis is caused by the high temperature and the cyanosis is caused by a lack of oxygen due to the decreased pulse (Kent 34). The author of Influenza Pandemic of 1918-1919, Susan Kinglsey Kent, provides a brief history of the pandemic and documents from the time period. Many of the included documents show how unprepared and unorganized governments attempted to contain and control a disease they had never experienced, and how the expectations of the governments changed as a result of their successes and failures.
Edward Jenner is often regarded as the “Father of Immunology” for his development of the smallpox vaccine. His remarkable discovery has laid the foundation for future scientists working with immunizations. Jenner’s impact is seen worldwide to this day with the complete eradication of the deadly smallpox virus. Edward Jenner’s Legacy will always live on as the first to vaccinate using a live virus. Vaccines are improving everyday, which benefits the public’s health, all thanks to Edward Jenner.
Jonas Salk, a virologist at the National Foundation for Infantile Paralysis (NFIP), used inactivated viruses (virus particles grown in culture and then killed by a form of heat) to create a polio vaccine. Salk drew blood from about two million children, which the NFIP checked for immunization. Through the collection of many HeLa cells and trial and error, the polio vaccine was ready in a year.... ... middle of paper ... ...
At no time was a search for the cure for influenza more frantic than after the devastating effects of the pandemic of 1918. The pandemic killed somewhere between twenty and a hundred million people, making it twenty five times more deadly than the ordinary cough and sneeze flu. The symptoms of this flu were like something straight out of a horror movie: the victim’s facial complexion changed to a dark, brownish purple, the feet turned black, and they began to cough up blood. Eventually, death was caused, literally by drowning, when the victim’s lungs filled with their own blood. The first scientist to claim to solve the enigma of influenza was Dr. Friedrich Johann Pfeiffer. He isolated a bacterium he named Hemophilus influenzae from the respiratory tract of those who had the flu in the pandemic of 1890. He was believed to be correct in his discovery until the pandemic of 1918, when scientists searched the respiratory tracts of influenza victims and only sometimes found his bacterium. Robert E. Shope and his mentor Paul Lewis were the next to attempt to crack the code of influenza. They chose to study the disease in pigs, a controversial choice because many people believed that the swine influenza pigs were contracting was not the same as the human flu. The first experiment they ran was ba...
Polio: An American Story describes a struggle to find a vaccine on polio through several researchers’ lives, and over the course of many years. The second thesis is the struggle between Salk and Sabin, two bitter rivals who had their own vaccine that they believed would cure polio. The author David M. Oshinsky, is describing how difficult it was to find the cure to a horrifying disease, which lasted from the Great Depression until the 1960’s. Oshinsky then writes about how foundations formed as fundraisers, to support polio research. Lastly, the author demonstrates how researchers were forced to back track on multiple occasions, to learn more about polio.
“The Site of Origin of The 1918 Influenza Pandemic and Its Public Health Implications.” Barry, John. US national Library of Health Medicine, January 20, 2004. Retrieved from:
Dawson, Liza. "The Salk Polio Vaccine Trial of 1954: Risks, Randomization and Public Involvement in
Jonas Salk M.D. developed the polio vaccine. Salk's vaccine was composed of a "killed" polio virus. This virus kept the ability to immunize while preventing the infection of the patient. Later a "live" vaccine was developed from the live polio virus. This "live" vaccine could be administered orally as opposed to the "killed" vaccine which required an injection. There was some evidence that the "killed" vaccine didn't completely eliminate the virus in the patient. United States public health authorities decided to distribute the oral "live" vaccine to eliminate the polio virus instead of Salk's "killed" vaccine. Unfortunately, the "live" vaccine infected some people instead of immunizing. Countries that used Salk's "killed" vaccine have nearly eradicated the virus.