Ipilimumab and stage 4 Melanoma
The Problem - Skin Cancer (Melanoma):
Evidence suggests that skin cancer is caused by prolonged and repeated exposure to UV rays (NHS, 2013). The main source of UV rays is from direct exposure to the sun. When large amounts of ultraviolet radiation pass through your DNA they can damage it. However, not all skin cancers develop from UV rays, some forms are hereditary. A faulty gene can be passed through generations and cause Familial Malignant Melanoma. People with paler skin or excessive numbers of moles are more likely to develop the disease as their body may not be producing enough melanin, which is responsible for blocking UV rays. If there is less melanin in a person’s skin then more UV rays pass through and more damage will be done. ((NHS, 2013).
The sun can be dangerous as it emits UV rays, which can penetrate and damage DNA (Cancer Research UK, 2013). This can change the nucleotide bases, which are what DNA is made up of. When the DNA is copied the base is incorrect and damaged, this leads to a mutation (University of Utah, 2013). Figure 1 shows how external factors can damage DNA. Prolonged exposure to UV rays can result in the mutation of cells, which then develop into a cancer.
Approximately 100,000 people a year in the UK are diagnosed with a form of skin cancer and 12,000 of these people are diagnosed with the deadliest form of the cancer: ‘Melanoma’ (Cancer Research, 2013). When the cancer is identified at an early stage, there is a greater chance of a successful treatment. Melanoma will usually be treated through a radiology course (using x-rays to destroy cancer cells) or through surgery (where the tumor(s) are surgically removed). (Macmillan, 2013). Survival rates for st...
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Melanoma is an extremely important issue, as 75% of skin cancer deaths in Australia are attributed to melanoma, making it the most dangerous form of skin cancer in the country (AIHW 2010). The AIHW also states that Australia has the highest occurrence of melanoma in the world, with over 12,500 Australians being diagnosed annually, and having a recorded 1500 deaths each year. The Melanoma Institute of Australia states that melanoma is the “most common cancer in young Australians aged 15-39”, and that “rates have doubled in the 20 years from 1986-2006”. The incidence of melanoma is increasing more rapidly than any other major cancer. Owing to the high incidence and mortality rates of the disease in Australia, melanoma is the most life-threatening form of skin cancer in the country, making it a very serious non-communicable disease.
Skin cancer is a significant public health issue in Australia. Exposure to ultraviolet radiation emitted by the sun in the UVA and UVB wavelengths is the primary cause. Australia has been a world leader in efforts to protect the ozone layer, the main line of defense against ultraviolet radiation emitted by the sun. Ultraviolet radiation induces the formation of thymine dimers that cause mutation of skin cells if not repaired before DNA replication. Mutations of tumor suppressor genes can lead to uncontrolled cell growth. Ultraviolet radiation also causes immunosuppresion that allows skin cancers to become established. Basal cell carcinoma, squamous cell carcinoma, and melanoma are types of skin cancer caused by sun exposure, though each form is associated with a different pattern of exposure. Australia has the highest rate of skin cancer in the world, due to a combination of tropical latitude, fair-skinned population, outdoor lifestyle, and high amount of ambient ultraviolet radiation. Widespread opinions about tanning and health benefits of sunlight lead many Australians to intentionally overexpose themselves to the sun. State cancer councils have developed sun safety and awareness campaigns, such as “Slip! Slop! Slap!” and “SunSmart,” to educate the population about sun exposure and encourage early detection of skin cancers. Gradual changes in knowledge and behavior indicate that the fight against skin cancer can be won.
When people are exposed to UV light, from the sun or, for example, in a tanning booth, the melanocyte cells make more melanin and pack together tighter, resulting in darker skin tones. If the skin is receiving too much ultraviolet light, the melanocytes may begin to grow abnormally and become melanoma during this process.
Tanning can be harsh to your skin. The light coming from the sun contains different wavelengths of ultra violet (UV) waves. The two types of waves concerned about are UVA rays and UVB rays. UVA rays are long waves that cause more damage than a UVB ray. UVA rays penetrate deeper into your skin and cause tanning (“The Dangers of”). More and more exposure to UVA rays can cause permanent damage ...
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Skin cancer has been overlooked for the past few decades because the medical community has been focusing more on internal cancers. But with in exponential rise in recorded cases of skin cancer, it is grabbing attention now. Skin cancer is a serious problem and society is brushing it off so people might sport a nice tan. Even though skin cancer is not the type cancer that people see everyday or have family members develop it as often as say, breast cancer or prostate cancer, that does not make it any less of an important item to keep a look out for.
Sun shine contain ultraviolet ray which can cause the sunburn or even skin cancer. According to Cancer Council in Australia, Australia has highest incident rate of skin cancer in the world. More than 430000 Australians are diagnosed with skin cancer each year. There are approximately 60 percent of people who have got skin cancer will survive greater than five years after they diagnosis (Cancer Council Australia, 2014). In order to protect people under the sun, the sun protective behaviour is significant necessary.
Over all, skin cancer is known to be a very common and dangerous cancer among the U.S.. Although there is no superior or particular cause known for it, it can be reduced by reducing radiation exposure from the sun and also tanning booths and beds. If not attempting to prevent it by staying out of the sun, and seeking not seeking shade and so forth, protection such as longer clothing garments that better cover the body as well as hats and sunglasses can help to eliminate direct exposure and reduce some of the damages that may occur. Certain amounts of sun light are healthy for the body as it provides vitamin- D which the body needs to maintain a healthy life style, though it is crucial not be over exposed as reverse side affects may occur, causing more harm than good.
Most forms of skin cancer are found on areas of the body that experience constant exposure to sunlight. The ultraviolet rays in sunlight are one main cause of skin cancer, but artificial sources of UV rays have also been proven to be a contributing factor.
Rudy, Lisa J. "What Causes Autism?" About.com Autism Spectrum Disorders. About.com, 23 Dec. 2010. Web. 21 Feb. 2014. .
UV radiation causes significant damage to human skin, in the form of sunburns, aging, skin cancer, and nonmelanoma tumors. Human skin damage is primarily a result of tanning. The
The cancer cells from gene-mutation. Scientists now know some of the risk factors for lung cancer can cause certain changes in the DNA of lung cells. These changes can lead to not normal cell growth and, sometimes, cancer. DNA is the chemical in each of our cells that makes up our genes and how our cells function. People usually look like their parents because they are the source of our DNA. But DNA affects more than how we look; it also can affect our risk for developing certain diseases, including some kinds of cancer like lung cancer etc…Some people inherit DNA mutation from their parents that greatly increase their risk for developing certain cancers.
Skin Cancer is caused by hereditary factors, overexposure to the sun, and weak immune systems. (“Skin Cancer” infotrac.com) One reason people tend to get skin cancer is when someone in your family has passed their genes down to you, known as hereditary. Normally hereditary is one of the causes in the development of melanoma. For all types of skin cancers, overexposure of the skin to UV radiation in sunlight is the most frequently blamed source of skin cancer. “Research suggests that sunburns received early in one’s childhood can lead to skin cancer later in life” (“Skin Cancer” infotrac.com). For example, when someone gets sunburned, you usually don’t know till ten to twenty years after and that’s why people don’t get skin cancer till they reach their twenties.
The major environmental risk factor for melanoma is overexposure to ultraviolet (UV) radiation from the sun. People who have fair skin that burns or freckles easily need to be especially careful in the sun as protecting yourself against UV overexposure is an important way you can help reduce your risk of developing melanoma.
Probably the most commonly used word by your dermatologist, your beautician, your pharmacist or just the girl next door, and for a good reason. The sun’s damaging UV rays can single-handedly destroy your skin over time and in some cases even cause irreparable damage. It will burn your skin, dry it out, destroy collagen fibers and predispose you to cancer. Whether it’s a scorching sun or not, whether you are outdoors or not, sunscreen is an everyday must-wear. You have a choice.