522 Infectious Disease Project
Rush Royals
Natalia Rich, Amy Richards, Ryan Rickley, Brianne Riley, and Nicole Roehrig
Identify the components of the Chain of Infection and specify Modes of Transmission to the development of the following infectious diseases: Ebola, Legionnaire’s Disease, Toxic Shock Syndrome. For each disease, identify the methods of “breaking” the chain of infection. (This section may not exceed 3000 words)
Ebola
Disease Description
Ebola virus was first discovered in 1976 in Africa near the Ebola River Valley; this rare virus causes hemorrhagic fever and has been active in that region resulting in mortality rates of up to 90% (Sullivan, Yang, & Nabel, 2003). Until recently, the Ebola virus had not been seen in the United States.
Chain of Infection
The Ebola chain of infection begins with the resevoir of the infectious agent. Although information is known about the disease and its course of action, the natural host or reservoir of Ebola has yet to be identified. Scientists believe that animals such as bats, monkeys, chimpanzees, and gorillas are the cause of spreading the virus to humans (WHO, 2014). Currently, primates and humans are the only mammals known to become infected with the virus (CDC, 2014a). The disease causing agent for the Ebola virus derives from the virus family, Filoviridae, which has five identified species: Ebola virus (Zaire ebolavirus); Sudan virus (Sudan ebolavirus); Taï Forest virus (Taï Forest ebolavirus, formerly Côte d’Ivoire ebolavirus); Bundibugyo virus (Bundibugyo ebolavirus); and Reston virus (Reston ebolavirus). The first four have documented cases affecting humans, but the fifth species is only known to cause disease in primates (CDC, 2014a). The portal of exit for th...
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Mayo Clinic. (2014a). Disease and conditions- Legionnaire’s disease. Retrieved from http://www.mayoclinic.org/diseases-conditions/legionnaires-disease/basics/risk-factors/con-20028867
Mayo Clinic (2014b). Disease and conditions- Toxic shock syndrome. Retrieved from http://www.cdc.gov/mmwr/preview/mmwrhtml/00000273.htm
Scub, T., & Winn, E. (2005). Quick lesson: Toxic shock syndrome. Cinhal Information Systems. Retrieved from http://web.a.ebscohost.com.ezproxy.rush.edu/ehost/pdfviewer/pdfviewer?sid=163b920a-312f-4936-b7cf-5b93e17da59d%40sessionmgr4001&vid=37&hid=4212
Sullivan, N., Yang, Z., & Nabel, G. (2003). Ebola virus pathogenesis: Implications for vaccines and therapies. Journal of Virology. 77(18), pg 9733-9737.
World Health Organization (2014). Ebola virus disease. Retrieved from http://www.who.int/mediacentre/factsheets/fs103/en/
Zaire, Ebola, Sudan, and now, Reston. These are all level four hot viruses. That means there are no vaccines and there are no cures for these killers. In 1976 Ebola climbed out of its primordial hiding place in the jungles. of Africa, and in two outbreaks in Zaire and Sudan wiped out six hundred people.
The main objectives of the pathogen are to gain entry inside the host, once inside grow and reproduce, and avoid host defenses. There are three possible routes of infection: respiratory, alimentary, and traumatic. The respiratory route is the easiest and most direct means of entry. Under crowded conditions, the rate of infection is even more rapid. The diseases brought over to America were mainly spread by the respiratory method. The alimentary pathway of infection is through the ingestion of contaminated food and water. Throughout Europe during the 15th century, food and water were contaminated with fecal matter and by unsanitary habits ( i.e. the lack of bathing). The traumatic route of infection is through insect and animal bites.
Also considered as a hemorrhagic fever, MVD can affect both humans and animals, specifically those of primate species. The virus is classified as a unique strand – so unique that it is one of five in the same family to include that strand of the Ebola virus. The virus can contain as little as one strand to be contagious and can survive up to two weeks in blood specimens at room temperature. The incubation period, which is the time between exposure and when symptoms begin to appear in victims, is 2-21 days. Research suggests that the RNA strand is a filo-virus and that the highest inter-human transmission takes place from contact with body fluids or injections. Subcutaneous transmission also occurs especially when caring for an ailing loved one and/or disposing or pr...
Malaria is a common infectious disease found mainly in the tropics but in rare circumstances can be found in temperate areas. Depending on the circumstances malaria can be either life threatening cause serious illness.
Healthcare-associates Infections (HAIs) are infections that patients acquire during the course of receiving healthcare treatment for other conditions and can be devastating or even deadly ("CDC - HAIs the Burden - HAI", 2013). An HAI was defined as a localized or systemic condition that (1) results from an adverse reaction to the pres¬ence of an infectious agent(s) or its toxin(s), (2) that occurs during a hospital admission, (3) for which there is no evidence the infection was present or incubating at admission, and (4) meets body site-specific criteria (Klevens et al., 2007, p.2).
Ebola, a virus which acquires its name from the Ebola River (located in Zaire, Africa), first emerged in September 1976, when it erupted simultaneously in 55 villages near the headwaters of the river. It seemed to come out of nowhere, and resulted in the deaths of nine out of every ten victims. Although it originated over 20 years ago, it still remains as a fear among African citizens, where the virus has reappeared occasionally in parts of the continent. In fact, and outbreak of the Ebola virus has been reported in Kampala, Uganda just recently, and is still a problem to this very day. Ebola causes severe viral hemorrhagic fevers in humans and monkeys, and has a 90 % fatality rate. Though there is no cure for the disease, researchers have found limited medical possibilities to help prevent one from catching this horrible virus.
This chain of infection develops when each link connects to the other. That means it must link up together in order to be infectious diseases. However, the breaking away of any of the link will mean that, transmission of infection is stopped. On the other hand, breaking of any chain can stop the transmission
Ebola Zaire was identified in 1976 in Northern Zaire and was the first documented appearance of the virus.
Hospital acquired infections are one of the most common complications of care in the hospital setting. Hospital acquired infections are infections that patients acquired during the stay in the hospital. These infections can cause an increase number of days the patients stay in the hospital. Hospital acquired infections makes the patients worse or even causes death. “In the USA alone, hospital acquired infections cause about 1.7 million infections and 99,000 deaths per year”(secondary).
This virus is similar to Ebola, because it started in the same place. Lab workers in Germany, in 1967, contracted the new virus while working with African Green Monkeys, which had the virus. The virus is described as a hemorrhagic fever. It has a fatality rate up to 90% and spreads through human to human contact. The first symptoms can be as simple as a fever and a headache, then can progress to organ failure, and fatal internal bleeding.
In 1976 the first two Ebola outbreaks were recorded. In Zaire and western Sudan five hundred and fifty people reported the horrible disease. Of the five hundred and fifty reported three hundred and forty innocent people died. Again in 1995 Ebola reportedly broke out in Zaire, this time infecting over two hundred and killing one hundred and sixty. (Bib4, Musilam, 1)
Marburg virus belongs to the genus Marburgvirus in the family Filoviridae, and causes a grave hemorrhagic fever, known as Marburg hemorrhagic fever (MHF), in twain humans and nonhuman primates. Basic Safety measures for medical personnel and others who are taking care of presumed individuals who may be contaminated with Marburg disease. Marburg Virus, Akin to the more widely known Ebola hemorrhagic fever, MHF is portrayed by systemic viral replication, lowering the body’s normal immune response to invasion by foreign substances and abnormal inflammatory responses. Ebola and Marburg Virus are very similar in many ways Marburg virus was introduced first in the 1960’s. These pathological features of the disease subsidize to a numerous of systemic dysfunctions including
According to the World Health Organization (2014) “Ebola first took place in 1976 in 2 simultaneous outbreaks, one in Nzara, Sudan.., in Yambuku, Democratic Republic of Congo. [and the] latter occurred in a village near the Ebola River, from which the disease takes its name”. The disease has also started spreading through countries such as Guinea, Sierra Leone, and Liberia (which are West African countries). The United States of America had their first case of Ebola on September 30, 2014, when a man traveling back from Liberia was diagnosed with the disease in Dallas, Texas (CDC 2014). The man did not show symptoms until he reached the United States.
Today it is no longer a novelty to hear that teenagers are having sex. However, while this “bedroom” activity may be fun, there are now ample reports indicating that rates of sexually transmitted diseases (STDs) in teenagers have skyrocketed. Current data reveal that nearly 25% of adolescent girls who have sex are infected with one of the four commonly sexually transmitted infections-namely gonorrhea, chlamydia, herpes and HIV (Kann et al, 2015). Nationally, the prevalence of STDs account for 50% of cases in people under the age of 25. While every ethnic and race has been known to be affected, African American youth are disproportionately affected. These data are not a surprise to professionals who are engaged in adolescent sexual health because the numbers have been slowly creeping up over the decades, despite national educational policies to counter the threat of STDs (Sales & DiClemente, 2016). All the STDs have a significant impact on sexual and reproductive health, if they are mot promptly diagnosed and treated. Although many preventive strategies have been implemented in all communities, the rates of STDs are still increasing (Madkour et al, 2016).
Sexually Transmitted Diseases Sexually Transmitted Diseases STDs, a.k.a venereal diseases, infectious diseases passed from one person to another during sexual contact. STDs are the most common infections known. More than 12 million people in the United States, including 3 million teenagers, are infected with STDs every year. The United States has the highest STD rate in the world about one in ten Americans will contract an STD during his or her lifetime. People who do not know they are infected risk infecting their sexual partners and, in some cases, their unborn children. If left untreated, these diseases may cause pain or may destroy a woman's ability to have children. Some STDs can be cured with a single dose of antibiotics, but AIDS cannot be cured. Those most at risk for contracting STDs are people who have unprotected sex—without using a condom, people who have multiple partners, and people whose sex partners are drug users who share needles. Static’s show that Americans between the ages of 16 and 24 are most likely of catching STDs than older adults, because younger people usually have multiple sexual partners than an older person in a long-term relationship. Teenagers may be embarrassed to tell their sexual partners they are infected Teenagers may also be embarrassed or unable to seek medical attention for STDs. This means that they only more likely to pass the disease to other young people and have a greater risk of suffering the long-term consequences of untreated STDs. STDs are transmitted by infectious bacteria, viruses, parasites, fungi, and single-celled organisms called protozoa that live in warm, moist parts of the body, like the genital area, mouth, and throat. Most STDs are spread while having sex, but oral sex can also spread disease. Some STDs are passed from a mother to her child while pregnant, when the disease enters the baby's bloodstream, during childbirth as the baby passes through the birth canal, or after birth, when the baby drinks infected breast milk. AIDS can be transmitted by blood contact such as open wounds, between people who share infected needles or received through an injection of infected blood. Some people believe that STDs can be transmitted through shaking hands or other casual contact, or through contact with inanimate objects such as clothing or toilet seats, but they can’t. Chlamydeous, is from trachoma is bacterium, is the most commonly transmitted STD in the United States.