IgA1 protease has a unique structure and function, however, only little is known about it. It is independent with respect to its processing and maturation due its ability to self-cleavage at specific hinge-like sequences linking its domains (Pohlner et al, 1987). IgA1 proteases have high selectivity for the targeted bond in the hinge region of IgA1 antibody. Depending of the targeted bond, IgA1 proteases were divided into two types: IgA1 protease type 1 which cleaves the second Pro-Ser bond in the
Jane. Neisseria gonorrhoeae evades host immunity by switching off T lymphocytes. The Lancet. Feb 23, 2002 v359 i9307 p681. Senior, B.W., Steward, W., Galloway, C., Kerr, M. Cleavage of the Hormone Human Chorionic Gonadotropin, by the Type 1 IgA1 Protease of Neisseria gonorrhoeae, and Its Implications. Journal of Infectious Diseases. Oct. 1, 2001 v184 i7 p9022.
Introduction Vaccine development is an old and complicated process, often requires more than a decade to complete. The modern system of vaccine development, regulation and testing was developed during the 20th century. To engender a vaccine mediated immunization or protection has been a major challenge. Presently available vaccines work primarily through the induction of the antigen specific antibodies. The effectiveness of any vaccine is determined by the quality of the antibodies, as their work