IgA1 Proteases

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The main and known functions of IgA1 proteases are cleaving the hinge IgA1 antibody which allows the colonizing colonies to escape the agglutination by the IgA1 antibodies and inhibits the mucociliary clearance. The other function is the autoproteolysis of the precursor protein which results in the maturation and secretion of the IgA1 protease. However, Vitovski and Sayers (2007) proposed that IgA1 protease has the ability to cleave substrates lacking the proline, serine and threonine rich sequence. The fact that only invasive isolated of pathogenic bacteria (mentioned 1.3.1 and 1.3.2) produces IgA1 protease drives the assumption of IgA1 protease as virulence factor. 1.7.2 IgA1 protease targeted substrates Several studies reported the interaction between IgA1 proteases and different substrates: Ayala et al (1998) reported that Neisserial IgA1 type 2 protease has the ability to degrade Lysosome associated membrane protein (LAMP1) which is a member of a unique class of glycoproteins located on the lysosomal membrane. Lysosomes are degradative organelles that contain acidic enzymes ...

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