Hypothesis Of The Hygiene Hypothesis

1226 Words5 Pages
HISTORY Hygiene is defined simply as conditions or practices conducive in maintaining health and preventing disease, through cleanliness. Hypothesis is a supposition or proposed explanation made on the basis of limited evidence as a starting point for further investigation. Medically, the hygiene hypothesis is a one proposing that absence of exposure to early childhood to infecting agents such as symbiotic microorganisms (e.g. GIT flora or probiotics), and parasites increases prone to allergic diseases by suppressing the natural development of the immune system (Strachan D. 2000). Reduced exposure is thought to lead to problems in tolerating immunity. The original formulation of the hygiene hypothesis dates from 1989 when Strachan proposed that lower incidence of infection in early childhood could be an explanation for the rapid 20th century rise in allergic diseases such as asthma and hay fever (Strachan, D, 2000). The hygiene hypothesis has also been referred to as the "biome depletion theory" and the "lost friends theory" (William P, 2010) INTRODUCTION Cytokines; Interleukin- 4, IL-5, IL-9, IL-13 produced by the Th2 response are a mediated immune response towards maintenance and amplification of allergic reactions. They perform impressive duties in our immune system which…show more content…
These genes causing dysregulation of the immune system originating symptoms as seen in Insulin Dependent diabetes Mellitus, ulcerative colitis skin disorders and even Crohn’s disease and severe infections (Gambineri E et al., 2003). It has also been seen in few studies Th1 mediated pathologies; inflammatory bowel disease and decreased immune response to pathogens are pervasive over allergic presentations. Suggesting the natural foxp3 expressing T-reg cells are more important in suppressing Th1 than Th2 mediated disorders. Th2 cells are much less susceptible to CD4+ and CD25+ than Th1 due to responsiveness to different

More about Hypothesis Of The Hygiene Hypothesis

Open Document