In Science there are many different types of diseases that have been discovered, some of those diseases have been linked to genetics. One specific genetic disease is Huntington’s disease. Huntington’s disease is a genetically linked disease that is cause by a dominant allele. While Huntington’s disease is genetic, there is concepts behind as to how exactly Huntington’s disease becomes genetically linked to an individual who acquires the disease. Huntington’s disease is a genetic disease that has been deemed fatal because of the nature and side effects of the disease. The disease affects motor, cognitive, and physical abilities of each individual affected by the disease. The disease is ruled a degenerating disease because the lack of motor, cognitive, and physical abilities leads to dementia, and or depression. The disease is classified as a dominant inherited neurodegenerative disease, which is caused by CAG trinucleotide expansion in the exon 1 of the Huntingtin gene (Bissonnette 1). There is multiple numbers of CAG (glutamine) repeats in the Huntingtin gene. Polyglutamine expansions lead to a number of cellular abnormalities (Journal of Neuroscience). The chromosomes during development as a fetus are affected, chromosome four is the chromosome associated with change in the Huntingtin gene. The Huntingtin gene can be passed down from either male or female. The Huntingtin gene is expanded on one of the two chromosome fours. Either the mom or dad can have an expanded chromosome four gene which would be passed down, and looked as dominant. If one parent is affected with one of the two chromosome fours he or she is carrying that will be passed down to the child. About half of the eggs will contain the chromosome with the expanded H... ... middle of paper ... ... cells and causes an abundance of protein in the nuclei of cells. Usually the chromosome affected of someone who has Huntington’s disease is the Chromosome number four. Higher number of repeats of the CAG worse the symptoms and more likely to develop Huntington’s disease, the lower number of repeats the less likely you are to have symptoms and or develop Huntington’s disease. While it is a devastating disease there is research being done to try and slow the progression of this disease and or reduce development of the disease? The Mithramcyin treatment testing conducted on mice shed light on a possibility of probably helping individuals with Huntington’s disease and possibility slowing down degenerating brain function, and or loss of mobility skills. Hopefully in the near future Huntington’s disease will be more under control and help individuals who suffer from it.
The symptoms of Huntington’s disease increase slowly and last until death. Chorea is one of
Huntington’s disease (HD) is a progressive autosomal dominant neurodegenerative genetic disorder. HD was originally named Huntington’s chorea after Dr.George Huntington, an American physician who first gave a detailed note on the symptoms and course of the disease in 1872.Recently the name has been changed to Huntington’s disease to emphasize the fact that chorea is not the only important manifestation of the disease but several non-motor symptoms are also associated with this disease.[1]
Huntington's disease is a progressive brain disorder that is caused by a single defective gene on chromosome 4 — which is one of the 23 human chromosomes that carry a person’s entire genetic code (alz.org, 2013). This defect is dominant, w...
It is estimated that between .1 and 10 % of people who suffer from Huntington's
Huntington’s disease is named after George Huntington. This disease genetically is an inherited disorder that damages the mind and nervous system. This may affect actions of the body for example like movement, the ability to reason, awareness, and thinking and judgment. It can also affect their behavior. The word genetic is that the disorder is delivered on by each generation of offspring by special codes called genes(Patient.Co.Uk, 2011). Genes are relocated from a parent to offspring and is held to decide some characteristics of the children (Patient.Co.Uk, 2011).
Dementia can occur in relation to many different illnesses. Some of the most common of which are Huntington’s Disease,
The reason Huntington's disease is a hereditary disease caused by a single abnormal gene. Doctors considered a dominant disorder chromosome is because only one copy of the gene is defective, inherited from parents. If the parent has a faulty gene, the chance that their children will have disabilities is 50 percent. Because the signs and symptoms often first appear in middle age, some parents may not even know they carry the gene until they have children grow up. If the child does not inherit by the defective gene then they will not pass down the Huntington’s disease for the next
Huntington’s disease is a progressive neurological disorder that is caused by an autosomal dominant mutation in the HTT gene. There will be no change in the allele frequencies because this treatment only has an effect on the phenotype, not the genotype; it does not
Huntington’s disease (HD), also known as Huntington chorea, is an inherited disorder that causes the death and break down the nerve cells in the brain. This genetic disorder is a late onset in life, except for the rare occurrence of this disease, called juvenile huntingtons. Symptoms usually start appearing in people between the ages of thirty and fifty years old. However, if the symptoms become present before the
I looked up Huntington’s Disease to find out more about the disorder. There is no real treatment for the disorder, so I do not see any benefit of knowing that you are going to develop the disease. I feel the distress of knowing that a gene is present and the disease is going to come in time would be worse than the symptoms starting to manifest themselves. The early symptoms can develop any time, but in most cases, they develop in between the age range of 30 – 50 years of age. The initial signs and symptoms are very subtle causing problems with coordination, involuntary movement, and memory. The person affected may develop depression or irritable moods. In the early stages, there are some medications that can help with those symptoms.
Huntington’s disease is an inherited condition in which nerve cells in the brain break down over time. No cure exists for the disease, but drugs, physical therapy, and talk therapy can help manage some symptoms. Testing is done by blood sample. The genetic test analyzes DNA for the HD mutation by counting the number of repeats the Huntington gene made. Part of the gene repeats itself over and over again like a stutter. The results are near 100% accurate. The disease appears around age 40.
Huntington’s disease is caused by an abnormal dominant gene. Also called Huntington’s chorea, it is a complex disorder that affects a person capability to feel, think and move. The symptoms of Huntington’s disease consist of mood swings, irritability, depression, and anger. These symptoms are likely to worsen and the disease a lot of times runs in the family. If people have at least one parent with Huntington’s disease, the chances of them inheriting it are 50-50 chance. There is also a 50-50 chance that, that same person could pass the faulty gene on to their future child. This pattern of inheritance is called "autosomal dominant". The disease could also affect a person’s judgment and other mental functions. In some cases the person could
It's 6 a.m. and your alarm clock goes off. For most people you get up and get ready. When you have Huntington's disease it makes simple things much more difficult. A life with Huntington's disease would be a challenge.
Huntington’s disease (HD) is an inherited disorder that causes degeneration of neurons in regions of the brain that control motor functions and cognition (Ghosh, 2015). The disease was formally described for the first time in 1872 by George Huntington. In his essay, “On Chorea”, Huntington incorporated the medical records of the patients treated previously by his father and grandfather. He noted the hereditary transmission of chorea, its gradual onset and tendency of affected patients to insanity and suicide. Since the original discovery the name has changed from Huntington’s chorea to Huntington’s disease to acknowledge the multiple non-motor symptoms faced by patients (Rüb, 2015). The clinical features that Huntington observed remain true
Genetic disorders are diseases caused when certain mutations occur in DNA. There are a wide range of genetic disorders that are each caused by different genes and each have very different symptoms. There are three kinds of genetic disorders: single-gene disorders, chromosome abnormalities, and multifactorial disorders. In this document we will cover the three types of genetic disorders, examples of each type, and possible treatment of particular disorders such as Huntington’s disease, Down syndrome, and Alzheimer’s disease.