Human Health: Understanding the Activity of Signal Pathway

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The research, in this article, is significant to human health because the understanding of the activity of a signal pathway can or cannot give you a grasp on how it can affect other processes in the body. If the effects are known and understood, then we can know how to treat and/or modify the processes and give a discovery in the field of science.

Specifically, in this article, understanding the structure of chromatin is vital to understanding how it affects replication, transcription, and repair. If DNA is not available for enzymes to carry out these processes, then genomic activity will not be as effective. Modifying histones is key to understanding the regulation of chromatin and its changes, and how it influences gene expression. Histone modification caused by an active NFκB signaling since it acts like a regulator for this modification can alter the tumor growth and furthermore give a resistance to chemotherapy. During the cisplatin-based treatment, an active NFκB signaling averts histone acetylation, which removes the positive charge from the histones making the condensed chromatin into a more relaxed structure (Ropero & Esteller, 2007). Therefore, there is histone deacetylation, which makes the chromatin in a more condensed and less relaxed structure, which will not allow transcription to take place or other processes that are needed for enzymes to carry them out.

Overall, understanding the structure of histones and how an active NFκB signaling will permit or prevent histone acetylation and deacetylation can affect tumor growth and can or cannot promote head and neck cell squamous carcinoma chemoresistance.


In this article, since it was found that treating head and neck squamous cell carcinoma with cisplatin-b...

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...ed with understanding their views. Overall, the article helped with possibly providing a way for patients with head and neck cell carcinoma to inhibit NFκB signaling and promote histone acetylation so that the tumor cells are more sensitizing and allowed to die with the treatment of cisplatin-based chemotherapy.


Almeida, L. O., Abrahao, A. C., Rosselli-Murai, L. K., Giudice, F. S., Zagni, C., Leopoldino, A. M., et al. (2014). NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC). FEBS Open Bio, 4, 96-104. Retrieved March 7, 2014, from

Ropero, S., & Esteller, M. (2007). The role of histone deacetylases (HDACs) in human cancer. Molecular Oncology, 1(1), 19-25. Retrieved March 7, 2014, from
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