Every one in two thousand people are diagnosed with hereditary spherocytosis. This rare blood disorder is of the Northern European ancestry. The prevalence of hereditary spherocytosis in people of other ethnic backgrounds is unknown (Government). This disease should be detected in early childhood, but in some rare cases it can go undetected for years or never be detected at all. Hereditary spherocytosis not only affects the red blood cells but the spleen as well. It only takes one abnormal gene for
mutation is found in one of the spherocytosis genes causing erythrocyte membrane defects. The Laparoscopic approach has been one of the new surgical procedures for splenectomy for the treatment of HS. Partial splenectomy is done in children to avoid post-splenectomy sepsis. The latest management helps in understanding the protocol of splenectomy and suggest a meticulous discussion between the patient, the family and the healthcare provider. Hereditary Spherocytosis (HS) or Minkowski–Chauffard syndrome
This review is on the studies of several scientists whom completed research on the genetic disorder, spherocytosis. Based on several articles in the literature, it was learned that spherocytosis is an inherited anemia caused by the dysfunction of the cell’s cytoskeleton. These articles provide information of hereditary spherocytosis comprising of the disorder on the molecular level and how the patient’s diagnosis is concluded using laboratory testing. Patients can be found to be affected on a certain
then, after reproduction, the said affected gene gets passed to the offspring. Such genetic predispositions can result in disadvantages in those affected and present difficulties when trying to respond to or reverse the resulting disease. Hereditary spherocytosis and familial acute myeloid leukemia are two such conditions that affect normal red blood cell (RBC) and white blood cell (WBC) functions, respectively, that can also be passed from generation to generation. Currently, efforts to reduce the
performed on the blood that extracted from the arteries, like determining glucose level, hemoglobins and dys-haemoglobins, and electrolytes. The abnormal result indicate: -Drug-induced immune hemolytic anemia-G6PD deficiency-Hemoglobin C disease-Hereditary spherocytosis-Idiopathic autoimmune hemolytic anemia-Paroxysmal cold hemoglobinuria (PCH)-Paroxysmal nocturnal hemoglobinuria (PNH)-Sickle cell anemia-Thalassemia. An arterial blood gas (ABG) is a bloo...
human genome by the year 2003, one which illustrates the precise locations of every single gene in all twenty-three pairs of human chromosomes, along with the functions of these genes. The term gene is defined as being "one of many discrete units of hereditary information located on the chromosomes and consisting of DNA (Deoxyribonucleic Acid)." (Campbell, G-9) All these units put together comprise the genome. Many ailments that we suffer from are products of flawed genes. Cystic Fibrosis is the result
1.Human Erythrocytes. Human erythrocytes have a life span of about 120 days in circulation. This life span is achieved even though they have no nuclei or internal repair mechanism and thus have no major biosynthetic repair mechanisms. Compared to other cells in the body for example neutrophils that have a life span of only 5 days (11) the human erythrocyte circulate through the body for a long period of time, a full circulation on average take about 20 seconds to complete (12). Its main function