Introduction
Disease!!!!! Disease!!!! Disease!!!! Living on this earth we are exposed to a lot of different infectious Disease. Hepatitis E is a very serious liver disease caused by the Hepatitis E virus (HEV) that usually results in an acute infection.(http://www.cdc.gov/hepatitis). It’s safe to safe to say that Hepatitis E does not lead to a chronic infection according to CDC. In this research paper I will identify the causative agent, geographical distribution, transmission, clinical features, diagnosis, treatment, and the control measures of this serious liver disease. Key facts about Hepatitis E may include:
• Every year there are 20 million hepatitis E infections, over 3 million acute cases of Hepatitis E, and 57,000 hepatitis E related deaths.
• Hepatitis E is found worldwide, but the prevalence in highest in East and South Asia
• Hepatitis E is usually self limiting but may develop into fulminant hepatitis and is transmitted via faecal-oral route, principally via contaminated water.
• China has produced and licensed the first vaccine to prevent hepatitis E virus infection, although it is not yet available globally.
The Causative Agent
The causative agent for hepatitis E is the Hepatitis E virus (HEV). According to my research the virus originated from the stool of a volunteer orally infected with faces from suspect cases of non-A and non-B hepatitis (Balayan et al. 1983) hepatitis E virus is a non-eveloped, positive-sense, single-stranded ribonucleic acid (RNA) virus is approximately 27 to 30 nm in size (veterinami medicina 52, 2007) (HEV) infections are spreads by the faecal – oral route and causes acute sporadic and epidemic viral hepatitis worldwide, usually through contaminated water supply. (Vasickova et al, 200...
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...s first observed and described in 1983(Balayan et al., 1983). The virus has been extensively investigated since that time. After a long-termeffort to assign this virus to a taxonomic class, the virus has been classified in the Hepevirus genus, Hepeviridae family in 2004 (Emerson et al., 2004;http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/fs_hepev.htm).
Anti-HEV antibodies (or viral RNA) have not only been found in people, but also detected in various animal species (Arankalle et al., 1994,2001; Favorov et al., 1998).
Bibliography
(http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/fs_hepev.htm).
Who.int/Hepatitis E
1. http://www.cdc.gov/hepatitis/HEV/HEVfaq.htm
2.http://www.who.int/mediacentre/factsheets/fs280/en/
3. http://www.rightdiagnosis.com/h/hepatitis_e/intro.htm
4. http://www.vri.cz/docs/vetmed/52-9-365.pdf
5. http://hepatitis.emedtv.com/hepatitis-e/hepatitis-e.html
This extremely pathogenic zoonotic virus is now understood to travel from bat species, to equine intermediate hosts, to humans.[8, 10] The Hendra virus is listed as a Bio-Safety Level (BSL)-4, and can only be studied at a few adequately equipped laboratories worldwide due to its virulence.[1, 2] Case fatality rates
...res or treatments. It just goes to show how important HeLa cells have been to medicine and researches.
This condition can spread from one person to another (contagious). Toxin-producing E. coli can also spread from animals to humans. Most cases of E. coli infection come from cattle.
For example, those who travel to or live in countries where Hepatitis A is common, have sexual contact with someone who has Hepatitis A, men who have sexual encounters with other men, those who use recreation drugs, have clotting-factor disorders, or are household members or caregiver of someone who is infected with the virus. Other risk factors include intermediate and high endemicity areas include poor sanitation and regulations and lack of safe water. Also, residents from regions with low endemicity for the Hepatitis A Virus infection often remains susceptible in their adulthood. In areas where the virus is wide spread, most Hepatitis A infections occur during early childhood because children tend to ingest everything. As mentioned earlier, adults have signs and symptoms of illness more often than children. The severity of the disease and its fatal outcomes are higher in older age
The virus is primarily spherical shaped and roughly 200nm in size, surrounded by a host-cell derived membrane. Its genome is minus-sense single-stranded RNA 16-18 kb in length. It contains matrix protein inside the envelope, hemagglutinin and neuraminidase, fusion protein, nucleocapsid protein, and L and P proteins to form the RNA polymerase. The host-cell receptors on the outside are hemagglutinin and neuraminidase. The virus is allowed to enter the cell when the hemagglutinin/ neuraminidase glycoproteins fuse with the sialic acid on the surface of the host cell, and the capsid enters the cytoplasm. The infected cells express the fusion protein from the virus, and this links the host cells together to create syncitia.
HAV is known to be an infectious disease that usually occurs in children and young adults .The disease is usually transmitted from person to person through contaminated food, liquids or oral fecal route. An example would be when someone is carrying the virus and doesn’t wash their hands after using the restroom and then puts food in their mouth. HAV is most common in developing countries because of the living conditions and inadequate water, poor sewage facilities and sanitary conditions. The highest HAV levels in the world are from India,” Earlier reports suggest that India is hyperendemic for HAV infection2,4-6 with very high infection rates,” (Sowmyanarayanan). Most HAV are without severe complications, “Virus HAV infection rarely causes fulminant hepatic failure in people…,” (Vento,p.1) . The symptoms for HAV are high fever, nausea, vomiting and jaundice...
Hepatitis B is a DNA viral infection that causes damage and inflammation to the liver. It was first discovered in 1965 by Dr. Baruch Blumberg. The HBV virus is very contagious and is even thought to be the most serious form of viral hepatitis and the most common viral infection on Earth. “HBV is 100 times more infectious than HIV.” (Green, 2002, pg. 7) The virus can survive for about one week outside the body on a dry surface. According to Green (2002, pg. 7), “One in twenty Americans has been infected with the virus at some point in their lives.” Between the ages of 15-39 is when 75% of new HBV infections occur, according to Green (2002, pg.8).
Acute HBV infection is the most common type of infection in low endemic countries. The incubation period, from transmission to clearness, ranges from 40-180 days. The infection is either symptomatic or asymptomatic/ fulminant hepatitis. Children under the age of 5 years rarely experience symptomatic infection (10%), where’s about 30-40% infected adults and children above age 5 experience a symptomatic infection with yellowing of skin and teeth, vomiting, fatigue, laxity and abdominal pain [1].
Liver disease resulting from alcohol affects more than two million Americans and is one of the primary causes of illness and death. The liver frees the body of harmful substances, such as alcohol. While the liver breaks down alcohol, it produces toxins that can be even more dangerous than the alcohol consumed (“Beyond Hangovers: Understanding Alcohol's Impact on Your Health” 13). “These by-products damage liver cells, promote inflammation, and weaken the body’s natural defenses. Eventually, these problems can disrupt the body’s metabolism and impair the function of other organs” (“Beyond Hangovers: Understanding Alcohol’s Impact on Your Health” 13).
Hepatitis A is a usually short acting virus that occurs in humans and monkeys. It is caused by the Hepatovirus and the species is Hepatitis A Virus. There are two major ways in which Hepatitis A can be transmitted. One way is from person to person. This transmission occurs when the fecal matter of an infected person gets ingested by another person. Other ways Hepatitis A can be transmitted from person to person are through direct contact with an infected person, such as sexual contact, and sharing of needles for intravenous drug use. Hepatitis A can also be transmitted through coming in contact with contaminated food or water. Also foods that are uncooked or undercooked and have been contaminated with Hepatitis A can transmit the virus. (Bennett,
Recent research shows that, there are three major means by which infections can be transmitted and they include direct transmission, indirect transmission and airborne transmission (Hinman,Wasserheit and Kamb,1995). Direct transmission occurs when the physical contact between an infected person and s susceptible person takes place (division of public health, 2011). An example is a health care worker who attends to an Ebola patient, without gloves, gown and mask plus forget to wash his or her hand with soap and hot water and or a person having flu without the use of mask or washes his hand after sneezing easily passes the infection to the other through hand shake or surface touch, living the bacteria there for another vulnerable person to also touch if the surface is not disinfected with bleach. Studies makes it clear that, the spreads takes effect when disease-causing microorganisms pass from the infected person to the healthy person through direct physical contact such as touching of blood, body fluids, contact with oral secretion, bites kissing, contact with body lesions and even sexual contact. However, measles and chicken pox are said to be conditions spread by direct
What is hepatic cirrhosis? According to the medical dictionary hepatic cirrhosis is when scar tissue replaces the liver’s healthy tissue. This disease changes the structure of the liver and blood vessels that nurture it. It reduces the liver’s capability to produce proteins and process hormones, nutrients, medications, and poisons. Cirrhosis is an illness that gets worse over time and possibly can become life threatening. This serious illness is ranked as the ninth leading cause of death in the U.S. It is the third most common cause of death for adults between 45 and 65 years of age. It occurs in more than fifty percent of undernourished chronic alcoholics. Unfortunately it kills about 35,000 people per year. In other country’s such as Africa and Asia death from cirrhosis is usually caused by hepatitis B.
There is a disease spreading out in the world called Hepatitis C. It affects the liver and may cause the liver to fail. This disease is caused by a virus called Hepatitis C virus which is also known as HCV. About 32,000 people are affected with this disease per year only in the United States area. Some It’s a disease with many symptoms and many causes. of these symptoms are easy bruising, upset stomach and fever. These are just some of the many symptoms that come from the virus. Hepatitis Cs nature of the causative agent is determined by many things. The biological data of this disease is filled so much information. It is estimated that over 180 million people have gotten Hepatitis C and it is growing.
Hepatitis B, an infectious disease caused by the Hepatitis B virus (HBV, a DNA virus), was formerly called serum hepatitis, inoculation hepatitis and post-transfusion hepatitis. Infection with HBV may result in acute, fulminant or chronic hepatitis, sometimes even resulting in a chronic asymptomatic carrier state, apart from hepatocellular carcinoma and liver cirrhosis (Davis 179). The disease is transmitted when an individual comes in contact with infected blood or objects. It may also be transferred from an infected mother to her infant either during or after birth (Zuckerman et al. 211). Transmission may also occur by accidental inoculation from infected needles and hospital equipment, intravenous drug abuse, body piercing, tattooing, and mouth-mouth kissing (Zuckerman et al. 210). The risk of Hepatitis B is particularly high in individuals with multiple sex partners, and in homosexuals. The HBV virus occurs in morphologically different forms in the serum of infected individuals. HBV infection has an incubation period of about 75 days. Systemic symptoms of the disease include fatigue, fever, dyspepsia, arthralgia, malaise, and rash, while local symptoms include hepatomegaly, jaundice, dark urine, and pale stools (Davis 179; Zuckerman et al. 210).
This case study is about Abdul Chidiac, a 51 year old male, married with 4 children. He had a medical history of hypertension, hypercholesterolaemia and cirrhosis with two admissions in the last six months. He is a smoker and drinks beer, 5-6 bottles per day. As Carithers & McClain (2010) explained the patient’s medical history is another indicator of the risk for cirrhosis; the progression to cirrhosis is adaptable and may take time over weeks or many years. Cirrhosis is a liver disease characterized by permanent scarring of the liver that interferes with its normal functions including alcoholism. Most people who drink large amounts of alcohol cause harm to the liver in some way (Heidelbaugh & Bruderly, 2006). The cause of cirrhosis is not yet known, but the connection between cirrhosis and excessive alcohol ingestion is established (Jenkins & Johnson, 2010). Common causes of cirrhosis include: alcohol abuse, hepatitis B infection, hepatitis C infection and non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (Schuppan & Afdhal, 2008).