Hemophilia Manitoba
Hemophilia Manitoba, or hemophilia, is a sex-linked genetic disorder that is effecting about 20,000 Americans, most of which males. A person with hemophilia either has an inactive or inadequate supply of one of several blood factors needed for blood to clot. Because of this hemophilia can be mild, moderate, or severe. Severe hemophiliacs are at risk for bleeding during surgery, trauma, or even dental work. There are two types of hemophilia, A and B (Christmas disease). Hemophilia B is extremely rare. The majority of the people have hemophilia
A. In hemophilia A, the particular factor missing is 8 for clotting. Because hemophilia is sex-linked disorder, it can be passed on from mother to child. This is because the gene responsible for making blood factors 8 and 9 are only found on the X-chromosome. If a female is a carrier that means that she has one bad gene and one good gene for this disease. There is a fifty percent chance that she would pass it on to her child because she can only pass on one of the two chromosomes. If a male has hemophilia, he will have normal sons and all of his daughters will be carriers of the hemophilia disorder because all he can pass on is the defective X-chromosome.
Males mostly have hemophilia, but women can also have hemophilia. This is extremely rare though because two defective X-chromosomes would be needed. In fact, the first proven case of women having hemophilia was not until the 1950’s (Bornstein 89). Female carriers are also at risk. These women are known as asymptomatic carriers and may suffer excessive menstrual bleeding, bruising, nosebleeds, and problems during childbirth.
One serious problem with hemophilia is joint bleeds. When a joint bleeds, a small amount of blood leaks into joint space and can not escape the joint because it is covered by a capsule of tissue. If the bleeding is not discovered by this stage, blood will continue to fill up the joint space. The joint begins to swell and become uncomfortable. Eventually, the pressure inside will be greater than outside and the bleeding stops. Fortunately, the blood makes digestive enzymes that eats up the trapped blood. Unfortunately, the digestive enzymes will also attack the cartilage that covers the bones. After several bleeds, the cartilage can become worn out and the enzymes can eat away at the bone.
Hemophilia is either treated each time an internal bleed
Originally thought to be an obscure illness, it was later identified as the most common genetic disorder for those with a Western European background. However, due to its low penetrance rate, only one out of two hundred are said to have the condition. Hemochromatosis is treated by the practice of bloodletting. It is one of the oldest treatments recorded in history, with its earliest records dating as far back as 3000 years ago in ancient Egypt. Routinely bleeding is beneficial as it not only reduces the iron in the bloodstream, but also combats issues such as heart disease and high blood
Thrombocytopenia affects 6% to 10% of all pregnant women and, other than anemia, is the most common hematologic disorder in pregnancy (McCrae, 2010). The blood consists of three main ingredients: red blood cells, white blood cells, and platelets. Each plays an essential function to provide the human body with elements and protects the body against any exterior viral and infection. Platelets are responsible to help blood to clot. The deficiency or disorder of platelets lead to disease called Thrombocytopenia. This issue is diagnosed when platelets are less than 150,000 platelets per microliter of blood (Erkurt, et. al, 2012).
○ ABO incompatibility. People with an O blood type have antibodies that can attack blood cells in type A or B blood. If a mother 's blood type is O and her baby 's blood type is A or B, her antibodies may destroy the baby 's red blood cells and cause hemolytic disease.
Of the children of a hemophiliac male and a normal female, all the girls will be carriers and all the boys will be normal. Males cannot transmit the disability, and female carriers are free of the disease. Conventional wisdom suggests that 1 in 10,000 males in the United States have hemophilia. However, increased research and focus, on bleeding disorders in general and on bleeding disorders in women specifically, suggest a shift in what...
If this happens, the embryo may be implanted in the tube, causing a tubal pregnancy. This serious complication results in a miscarriage and can cause death of the mother. Rarely, untreated gonorrhea can spread through the blood to the joints. Gnorrhea is treated with antibiotic drugs taken orally or by injection.
There is no cure for hemophilia yet but they can stop or keep the bleeding episodes from happening by injecting themselves with “purified clotting factors.” Additional treatment is necessary only if the purified clotting factors were attacked by the person’s immune system.
This genetic disorder is not specific to a certain age, ethnic group, or gender; theref...
Tsar Nicholas II and his Tsarina, Empress Alexandra, had only one son, Tsarevich Alexei. However, Alexei had inherited from his great-grandmother Queen Victoria the life-threatening genetic disease hemophilia B, a sex-linked genetic disease on the X chromosome that caused a condition of deficiency in blood-clotting and excessive bleeding, symptoms that usually remain hidden unless contracted by a male (Fuhrmann 37; King 28). To Nicholas II, it was imperative that he have a son to succeed him to secure the throne. Alexei was Nicholas’s sole male heir, giving Nicholas the incentive to protect his son at all costs. Without a scientific cure for the genetic disease, Alexandra turned to religion, namely Grigori Rasputin, a poor uneducated Siberian peasant to protect her son.
The type of mutation that occurs in Down syndrome is aneuploidy that is the irregular number of chromosomes in a cell. The most common of the three is the trisomy 21 that occurs in about 90% of people with the disorder. In this factor the human is given three copies of the chromosome 21 instead of the common two copies. This occurs due to the complications of the cell division in the process of the egg or sperm. The next case is mosaic which happen when there are inequality of cells with three copies of chromosome 21 and others with the original two copies. Mosaic appears when there is an unexpected cell division after fertilization. The last and the rarest form is translocation and that happens while the chromosome 21 in cell division is broken off and attached to another chromosome. Since the disorder is unexpected there are numerous amounts of risk factors that are possible based on the severity of the person.
A person with hemophilia faces great problems. Any little scrap or cut even burse can give the person a hard time. With this condition a person faces prolonging bleeding. Surgery or evening getting a tooth pulled isn’t a great idea. This condition causes the blood clotting process to slow down. If you have this disorder you’ll be sure to know. You have be playing a street game of football one minute fall and scrap you’re your knee the next. And be hospitalizing at the end of the day. Even serious complication can result in bleeding into the joint, muscle, brain or other internal organs (U.S. National Library of Medicine, 2012) . You may not know if you have hemophilia until abnormal bleeding occurs after a serious injury or surgery. This may be hard for someone to take in.
Postpartum hemorrhage is the leading cause of maternal mortality in the world, according to the World Health Organization. Postpartum hemorrhage (PPH) is generally defined as a blood loss of more than 500 mL after a vaginal birth, more than 1000 mL after a cesarean section, and a ten percent decrease in hematocrit levels from pre to post birth measurements (Ward & Hisley, 2011). An early hemorrhage occurs within 24 hours of birth, with the greatest risk in the first four hours. A late hemorrhage happens after 24 hours of birth but less than six weeks after birth. Uterine atony—failure for the uterine myometrium to contract—is the most common postpartum hemorrhage (Venes, Ed.).(2013). Other etiologies include lower genital tract lacerations, uterine inversion, retained products of conception and bleeding disorders (Kawamura, Kondoh, Hamanishi, Kawasaki, & Fujita, (2014).
Malaria (also called biduoterian fever, blackwater fever, falciparum malaria, plasmodium, Quartan malaria, and tertian malaria) is one of the most infectious and most common diseases in the world. This serious, sometimes-fatal disease is caused by a parasite that is carried by a certain species of mosquito called the Anopheles. It claims more lives every year than any other transmissible disease except tuberculosis. Every year, five hundred million adults and children (around nine percent of the world’s population) contract the disease and of these, one hundred million people die. Children are more susceptible to the disease than adults, and in Africa, where ninety percent of the world’s cases occur and where eighty percent of the cases are treated at home, one in twenty children die of the disease before they reach the age of five. Pregnant women are also more vulnerable to disease and in certain parts of Africa, they are four times as likely to contract the disease and only half as likely to survive it.
He published a comprehensive medical description of the syndrome. It was not until 1959, that it became clear the syndrome was due to lack of sex chromosome material. Turner's Syndrome is a rare chromosomal disorder that affects one in approximately 2,500 females. Females normally have two X-chromosomes. However, in those with Turner's Syndrome, one X chromosome is absent or is damaged.
For almost all types of Albinism both parents or mates must carry an albinism gene in order for their child to have albinism. Because the body has two sets of genes, a person may have normal pigmentation but carry the albinism gene. If a person has one normal gene and one albinism gene that is still enough to pass the disease on to their children. Even if both parents have the albinism gene it does not mean they have the sickness. The baby will have a one out of four chance of getting the disease. This is inherited by autosomal recessive inheritance.
Blood Transfusions were a huge step into the field of medicine. Blood transfusions are when someone receives blood through an IV into their own blood vessels. People are able to be kept alive for longer if not for good with this discovery. Once they figured out how blood circulated throughout the body, blood transfusions became the next step. The first transfusion was done in the mid-1600’s using animals. It was only a couple years after that when a transfusion was performed on an actual human, and it worked. This discovery in medical science opened up a whole new world for people who were sick or dying. Not only did these blood transfusions help people who were losing blood, but it also helped cure people who were sick from diseases. Blood transfusions are an exceptional creation for the health of humans and this has made an enormous result in the way that physicians treat patients.