528 Words3 Pages
People who have hemophilia have little to no clotting factor. This disease is almost always inherited and is rarely ever developed during someone’s lifetime. Hemophilia comes in two types, A and B. It is more common in males rather than females but can be carried by females. Also known as Von Williebrand Disease (VWD), it is named after Dr. Erik Von Williebrand who assessed the disease differently in Helsinki, Finland in 1924. Without treatment, people with hemophilia die before they reach adulthood. When treated, life expectancy of males with hemophilia is about 10 years less than that of males without Hemophilia. Even though hemophilia is typically nonfatal, it still occurs in 1 in 5,000 male births and affects 20,000 people in America.
Hemophilia carried in a recessive X-linked pattern in the X chromosome. Specifically, hemophilia A is found in the F8 gene, while, hemophilia B is found in the F9 gene. If a male has an X chromosome carrying the faulty gene then the male will have Hemophilia. However, if a female has the faulty gene she will only carry the disease, unless, both her father and her mother have the faulty gene. Women don’t usually have hemophilia because they have enough normal clotting factors in their unaffected X chromosome. Men may get hemophilia even if their parents aren’t carriers, because, mutations occur in the F8 or F9 gene.

The symptoms of hemophilia exhibit excess external or internal bleeding. Symptoms of external bleeding include: bleeding in the mouth from a cut, bite, or from losing a tooth, nosebleeds for no obvious reason, excess bleeding from a minor cut, and/or bleeding that resumes after stopping for a short time. Internal bleeding symptoms include: blood in the urine (from kidneys or bladd...

... middle of paper ...

... Heart, Lung, and Blood Institute. Department of Health and Human Services , 01 Jun 2011. Web. 11 Dec 2013. .
"The Diagnosis, Evaluation and Management of von Willebrand Disease Scientific Overview." National Heart, Lung, and Blood Institute. Department of Health and Human Services . Web. 11 Dec 2013. .
"Hemophilia." Genetics Home Reference. Department of Health and Human Services , 10 Dec 2013. Web. 11 Dec 2013. .
"Fast Facts." National Hemophilia Foundation. National Hemophilia Foundation, n.d. Web. 11 Dec 2013. .
"DDVAP." Drug Information Online. Drugs.com, n.d. Web. 11 Dec 2013. .

More about Hemophilia

Open Document