These causes will change the heart significantly. The pathophysiology of heart failure is described differently as: (1) an oedematous disorder, by means of which the deviations in renal hemodynamics and excretory ability lead to salt and water holding; (2) a hemodynamic disorder, considered by peripheral vasoconstriction and decreased cardiac output; (3) a neurohormonal disorder, mainly by stimulation of the renin-angiotensin-aldosterone system and adrenergic nervous system; (4) an inflammatory syndrome, related with amplified local and circulation pro-inflammatory cytokines; (5) a myocardial disease, started with an damage to the heart trailed by pathological ventricular transformation. In heart failure, the heart sustains either a sudden or longstanding structural injury. When damage occurs, sequences of firstly compensatory but consequently maladaptive mechanisms follow (Henry & Abraham, ). Many compensatory mechanisms are stimulated in heart failure. These mechanisms involve rising ventricular preload, or the Frank-Starling mechanism, by ventricular dilatation and volume expansion, peripheral vasoconstriction to firstly sustains perfusion to significant organs, myocardial hypertrophy to protect wall strain as the heart expands, kidney sodium and water retention to improve ventricular preload, and start of the adrenergic nervous system, which elevates heart beat and contractile function. The activation of neurohormonal vasoconstrictor systems, which include RAAS, the adrenergic nervous system, and non-osmotic release of vasopressin will control these compensatory mechanisms (Henry & Abraham). These mechanisms contribute to the signs and symptoms of heart failure. However, the manifestations are nonspecific and do...
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...ilure is highly among the older populations and in developing nations. As individuals age, they are more prone to hypertension, atrial fibrillation, CAD, DM, MI and obesity, etc., leading to heart failure. Abnormalities of heart function are higher with increasing decade of life, particularly from age 50 years. Besides, the comorbidities occurs more in developed countries due to the different lifestyles. More people in developing countries are obese, diabetic and living longer, etc. All these issue stress the heart and eventually lead to heart failure (Krum & Abraham, ). Heart failure is common condition with many illnesses and condition. Knowing the illnesses and conditions that can cause heart failure will reduce the chance of having heart failure. Treat and control the conditions and illnesses can decrease the occurrence of heart failure even further.
In this figure, SN = sinus node; AVN = AV node; RA = right atrium; LA
In this paper, an overview of the components of the circulatory renin-angiotensin system and their productions will be given, along with evidence in support of a cardiac RAS. The local RAS of the heart deviate from the classical pathway in two ways, one being other sources of productions such as myocytes and fibroblasts that differ from renal or neural RAS, and the other being its functions and roles that distinguish it from other tissue RAS. Based on conducted research, the renin-angiotensin system is a critical component that contributes to the progression of heart failure (2). This has spurred further research on suppression of RAS in order to control the rate o...
It was to this respect that, the search could detect ‘’hypertension’’ as the leading risk factor for heart disease. And this preceded three quarters of heart failures cases as compared to coronary artery disease, which led to most heart failures in less than 40% of the cases. Also, an increase in left ventricular end-diastolic diameter became a mirror to the Framingham study as incident heart diseases in the individuals who are free from myocardial infarction. Although studies have shown that, the manifestation of heart failures can be present without the left ventricular systolic dysfunction, other risk factors could lead to that. Also, they (Framingham study) were able to detect ‘’too much of cholesterol’’ as a link to cardiovascular diseases. Moreover, research believed that has elevated among certain heart diseases such as coronary heart often leads to stroke, too high blood pressure among numerous patients. Having said that, the search discovered ‘’obesity’’ also as a concomitantly with hypertension which elevates lipids and diabetes versus questions on smoking behavior. Having said that, these risk factors are believed to have attributed to heart diseases. Therefore, it became a national concern to the general US population and that of the fourth director of Framingham heart study, William Castelli
Heart disease is the leading cause of death in the United States and the estimated cost of treatment is $32 billion yearly. Approximately 5 million people living in the United States suffer from congestive heart failure (CHF) and half of those diagnosed will die within 5 years. An individual may present to the hospital with weakness, short of breath (SOB), swelling of the extremities, ascites, and breathing difficulties while lying down. The quality and length of life for someone suffering from heart failure can be improved with early diagnosis, medication, physical activity, and diet modification (CDC, 2013).
The cardiovascular system - The cardiovascular system is responsible for transporting nutrients and removing gaseous waste from the body. It consists of the heart, which powers the whole process, the veins, arteries, and capillaries, which deliver oxygen to tissue at the cellular level. The cardiovascular system carries blood that is low in oxygen away from the heart to the lungs via arteries, where oxygen levels are restored through the air once oxygenated, this blood is then carried throughout the body via arteries, keeping our organs and tissue alive. The cardiovascular system is the workhorse of the body, continuously moving to push blood to the cells. If this important system ceases its work, the body dies.
Systolic and Diastolic are the two types of Heart Failure. Systolic dysfunction occurs when the heart muscle doesn't contract with enough force, which means there is less oxygen-rich blood that is pumped throughout the body. Diastolic dysfunction is the heart contracts normally, but the ventricle does not relax properly, reducing the amount of blood that can enter the heart and raise the blood pressure in the lungs. Heart failure is a progressive condition and can worsen over time. There are four stages of heart failure that have been classified by the AHA and ACC. Stage A are people that are at a high risk for developing heart failure. This includes people with high blood pressure, Diabetes, coronary artery disease and metabolic syndrome. Stage A also include people with a history of alcohol abuse, cardiotoxic drug therapy, rheumatic fever, and family history of cardiomyop...
Cardiovascular disease is currently the leading cause of death in the United States. It is responsible for one in four deaths every year, about 600,000 mortalities. This disease affects men and women, as well as every ethnic group. Coronary artery disease is the most common cardiovascular disease, representing approximately 400,000 deaths per year of the aforementioned 600,000 total deaths from cardiovascular diseases as a whole. In 2010 alone, coronary artery disease cost the United States $108.9 billion for health care services, medication, and lost productivity. These chilling statistics, published every year by the American Medical Association, demonstrate the immediate need for new and innovative ways to prevent, detect, and treat coronary heart disease. This paper will explore the molecular biology behind the disease while explaining the current treatments and prevention that are available today, why they work and what can be done to improve them.
Since 1960 the age-adjusted mortality rates for cardiovascular disease (CVD) has declined steadily in the U.S. due to multiple factors, but still remains one of the primary causes of morbidity and premature mortality worldwide. Greater control of risk factors and improved treatments for cardiovascular disease has significantly contributed to this decline (Centers for Disease Control and Prevention, 2011). In the U.S. alone it claims approximately 830,000 each year and accounts for 1/6 of all deaths under the age of 65 (Weiss and Lonnquist, 2011). Based on the 2007 mortality rate data an average of 1 death every 37 seconds is due to cardiovascular disease (Lloyd-Jones et al., 2009). Controlling and reducing risk factors is crucial for saving lives. There are a number of contributing risk factors for cardiovascular disease, which may appear in the form of hereditary, behavioral, and psychological, all of which ultimately converge in social or cultural factors.
State: The cardiac cycle is composed of five stages which each trigger the relaxation or contraction of the atria or ventricles and direction of blood flow.
One of the leading causes of death in the United States is heart disease. “Approximately every 29 seconds one American will have a heart attack, and once a minute one American will die from a heart attack” (Ford-Martin and Odle, 915). According to the Gale Encyclopedia of Alternative Medicine men over the age of 45 and women over the age of 55 are considered at risk for heart disease. Heart disease is a major cause of death. It is beneficial to individuals who seek to prevent heart disease to recognize the risks leading to heart attacks as they are one of the primary indications of developing heart disease; especially those that fall into the at risk age groups. These risks consist of some that cannot be changed such as heredity risks, or those that can change such as smoking habits. It is very important to know these specific risks for prevention and to understand the symptoms of heart attacks, such as sweating or the feeling of weakness so if these or other symptoms occur people are aware. Finally heart disease treatment is of vital importance if you experience a heart attack so you can learn how to prevent another one from occurring.
Just as breast cancer is killing our African American women, heart disease is also one of the major diseases killing our women. Heart disease is one of the nation’s leading causes of death in both woman and men. About 600,000 people die of heart disease in the United States (Americas heart disease burden, 2013). Some facts about heart disease are every year about 935,000 Americans have a heart attack. Of these, 610,000 are a first heart attack victim. 325,000 happen in people who have already had a heart attack. Also coronary heart disease alone costs the United States $108.9 billion each year. This total includes the cost of health care services, medications, and loss of productivity. Deaths of heart disease in the United States back in 2008 killed about 24.5% of African Americans.
Dilated cardiomyopathy accounts for approximately 15% of heart failure cases in the under 75s (“Chronic Heart Failure”). Patients with Dilated cardiomyopathy are usually unaware of the disease until they experience the signs and symptoms of heart failure or they develop an arrhythmia.
In “The Tell-Tale Heart” by Edgar Allan Poe, there are only five characters mentioned in the story: the narrator, the old man, and three police officers, none of whom is ever named. Throughout the story, the narrator tells the audience over and over that he is not mad. He becomes obsessed with trying to prove that he is not a madman and eventually goes crazy in the end. He tells the story of how he kills the old man after seven nights of watching him sleep. He has nothing against the old man and actually likes him, but it is the old man’s pale blue eye with a film over it that overwhelms the narrator with anger. This is when he decides to rid of this “vulture eye,” by murdering the old man. After finally finishing what he had set out to do, three policemen show up because of a complaint about a shriek. The narrator assures them that it was him that had shrieked because of a nightmare and asks the officers to sit with him. While talking with them, confident that they knew nothing, he starts to hear a noise increasingly get louder. He eventually cannot take it anymore and
Heart disease describes a range of conditions that affect your heart. Diseases under the heart disease umbrella include blood vessel diseases, heart rhythm problems, and heart defects. The major cause of this is a build-up of fatty plaques in the arteries. Plaque build-up thickens and stiffens the vessel walls, which can inhibit blood flow through the arteries to organs and tissues.
... patients with heart failure: Impact on patients. American Journal of Critical Care, 20(6), 431-442.