Introduction
Grave’s disease is a life threatening thyroid disease also known as toxic diffuse goiter; an autoimmune disease that allow the TSH to produce antibodies that makes the thyroid gland overproduce thyroid hormones. The Grave’s disease was identified during 1950’s based on the researched of Parry Grave and Von Basedow. They determined that the novel thyroid stimulator turned out to be an immunoglobulin G antibody. The assay used for the thyroid stimulator antibody and the epitopes involved on the thyroid stimulating hormone receptor has increased. The human genetics and environmental susceptibility was the biggest influence to the disease. The thyroid-associated ophthalmopathy is now described as the primary T-cell mediated disease resulting from cytokine stimulation of orbital fibroblasts (PubMed.gov, 2003).
Goiter is an enlargement of the thyroid gland. The pituitary gland stimulated the thyroid to grow and boost production of the hormone. The thyroid gland is located in the lower part of the neck below the Adam’s apple. The thyroid gland consists of two lobes joined in a similar band called the isthmus. The lobes are situated on the left and right side of the trachea and thyroid cartilage is below the larynx. The endocrine gland is covered with the connective tissue, which is made up of cells called follicles. The follicles are composed of simple cuboidal epithelium that produce and secrete thyroid hormones. The thyroid production is controlled by the hypothalamus, which signals the pituitary to release TSH (Cleveland Clinic, 2012).
The thyroid gland produces two main hormones, which are thyroxine (T4) and tridothyronine (T3). The thyroid gland provides iodine in the body. The T3 and T4 is biologically active; once...
... middle of paper ...
... are another good source of iodine and can be consume 4 times a week. The treatment for grave’s disease and hyperthyroidism cannot guarantee that the person will not experience side effects. It is proven that it might take several treatments for a person to be completely healed but there might be a relapse eventually especially if the provided maintenance is not taken regularly. The importance of radioactive iodine therapy depends on the right dosages used from treatment and if the person is responding to it. The person receiving a lower dose of radioactive iodine are more likely to require subsequent treatment than those being treated with higher dose (Metso, Jaatienn, Huhtala, et al., 2004). The risk involve in ignoring this disease will result in long term hardship and treatment. The importance of frequent doctor’s visit will help monitor the condition.
First I will be discussing about the thyroid gland, so the thyroid gland is a gland in the neck that secretes hormones. These hormones regulate growth and development, and metabolism. The main hormone secreted is Thyroxine. So when a person like Margie is diagnosed with hypothyroidism it means the thyroid gland does not secrete enough hormones. As many females get over the age of 50, they are more at risk of developing hypothyroidism. The symptoms
I should remember the lecture note that parafollicular cells of the thyroid gland produce calcitonin.
The location of the pituitary gland is in the sella turcica of the sphenoid bone and attaches to the hypothalamus(Marieb & Hoehn 441). The Hypothalamus is included in the function of the pituitary gland as it sends chemical stimulus to it(Marieb & Hoehn 442).Part of the pituitary is called the “ master endocrine gland” due to the fact that is produces many hormones that affect the whole body(Shannon 175).This part of the pituitary gland is called the anterior pituitary(Marieb & Hoehn 601). There are six hormones that the anterior pituitary secretes normally. These Hormones are growth hormones,thyroid stimulating hormones,adrenocorticotropic hormones,luteinizing hormones,follicle stimulating hormones and prolactin hormones( Shannon 175).The Hormone prolactin is one that in normal function stimulates the act of lactation for new mothers to feed their baby(Shannon 175).
Hypothyroidism develops when the thyroid gland does not produce enough of certain hormones. (“Hypothyroidism”, n.d.). Hypothyroidism can be broken down even further. The two types of hypothyroidism are congenital hypothyroidism or acquired hypothyroidism. According to Porth 2011, “Congenital hypothyroidism develops prenatally and is present at birth. Acquired hypothyroidism develops later in life because of primary disease of the thyroid gland or secondary to disorders of hypothalamic or pituitary origin.” (p. 786). Some common symptoms include increased sensitivity to cold, dry skin, fatigue, constipation, drowsiness, hypothermia and muscle weakness (“Hypothyroidism”, n.d.).
Thyroid and metabolism hormones play a large role in the daily lives of all living species. Thyroid hormones regulate the metabolism and the metabolism is responsible for maintaining a specific range for the biochemical reactions that occur in the body (Martini 2014). The most important hormone for metabolic maintenance is thyroxine (T4). This hormone also plays a large role in body heat regulation. It is produced by the pituitary gland and secreted by the thyroid gland. The thyroid releasing hormone (TRH) must trigger the thyroid stimulating hormones (TSH) to release thyroid hormones to the thyroid gland. These hormones are under control of the hypothalamus, or main neural control center. Propylthiouracil (PTU) is a medication used to treat
Graves’ disease is an autoimmune disease that was discovered by Robert Graves in 1835. Graves’ disease is an autoimmune disease in which the body's immune system attacks the thyroid gland and causes hyperthyroidism. Graves’ disease occurs when the antibodies like thyroid-stimulating immunoglobulin and thyrotropin receptor antibodies (TRAbs) attack the thyroid gland as if it were a foreign object or a virus of some sort. This disease is the most common type of hyperthyroidism. Attacking the thyroid gland in such a manner makes it excessively overproduce the hormone thyroxine which controls the body’s metabolic rate. Heightened activity of the thyroid can increase the body’s metabolism by 60% to 100%. (Weeks 34-35).
The hormones produced from the endocrine system come from a wide range of different places. Among those responsible for hormone production are the glands and a few organs as well. The glands that are involved are the pituitary, thyroid, thymus, parathyroid, and adrenal. The organs, which also play a vital part, are the pancreas, gonads, kidneys, heart, and parts of the digestive tract. All these different glands or organs work together in the production of certain hormones. Those produced in one location will almost always have an effect on many other areas of the body, not just the surrounding tissues.
In healthy an individual, the thyroid gland produces thyroid hormones T3 and T4 through a series of steps. Iodide is carry into the thyroid follicular cell from the blood stream by symporters. The iodide is transported into the cell against it concentration gradient, using Na+ concentration gradient as an energy source. The iodide in the follicular cell is activated through oxidation by thyroperoxidase (TPO). The active iodide is passively transported into the colloid through an iodide channel on the luminal side of the follicular cell down its concentration gradient. Thyroglobulin (Tg) another precursor of thyroid hormone enters the colloid via exocytosis from the Golgi complex of the follicular cell. The Thyroglobulin (Tg) binds to iodide with the help of thyroperoxidase forming monoiodotyrosine (MIT). If another iodide is added to the tyrosine reside of Tg, di-iodotyrosine is formed (DIT...
The balance of the thyroid hormone is complicated and involves the participation of different parts of the body (Kaplustin, 2010).
The thyroid organ, though small, impacts every cell in the body by providing metabolism regulation (endocrine web). This butterfly-shaped, endocrine organ located at the neck, secretes hormones to control the body’s metabolism - or the way the body uses energy that help the body with energy, manage heat, and help organs such as the heart and brain function properly (thyroid.org). When not functioning properly, thyroid dysfunctions occur disrupting the three points of control: the hypothalamus in the brain, the pituitary gland, and the thyroid gland. Common thyroid disorders include Hashimoto’s, Graves’ disease, thyroid disorders like hypothyroidism and hyperthyroidism, and nodules or goiters (health line).
Graves’ disease is considered an auto immune disorder. It is also a hyperthyroid disorder that leads to the over activity of the thyroid gland. Graves’ disease is a condition that occurs when the immune system mistakenly attacks healthy tissue. Many people suffer from symptoms. This paper will talk about the causes of the disease, research that has been conducted and how it can be treated.
The thyroid gland is found in the front of the neck and produces two main hormones. The hormones are called thuroxine (T4) and Triiodothyronine (T3). Together these hormones regulate the body’s metabolism by increasing energy use in cells, regulate growth and development, help to maintain body temperature and aid in oxygen consumption. These two hormones are regulated by hormones produced by the hypothalamus and pituitary gland. The hypothalamus senses changes in body’s metabolic rate and releases a hormone known as thyropin-releasing hormone (TRH). This hormone then flows through connecting vessels to the pituitary gland which signals it to release another hormone. This hormone is known as thyroid-stimulating hormone (TSH). TSH then makes its way to the bloodstream until it reaches the thyroid where it is then signaled to activate T3 and T4 production [1]. This mechanism is controlled by a negative feedback loop meaning that when there is a sufficient amount of thyroid hormones in the blood stream, this will signal back to stop production of thyroid stimulating hormones. Complications occur when the thyroid hormones keep increasing even though there is already a sufficient amount of T3 and T4 in the blood stream. This process of over expression of thryroid hormones is known as hyperthyroidism. Hyperthyroidism is a general term that includes any disease that has a consequence of an overabundance of thyroid hormones. Hyperthyroidism is a general term but there are many variant diseases that are in the hyperthyroidism category. These diseases include diffuse toxic goiter, Basedow’s disease, thyrotoxicosis, Parry’s and Graves’ disease.
I am a 24 year old, female that has a history of kidney stones and hyperthyroidism. I was diagnosed with hyperthyroidism that progressed into Grave’s disease in 2013. I am currently in remission and do not take any medication for it. I have never been pregnant. I was born in Romania. My younger sister, who is 17
Among these disorders are hypothyroidism and hyperthyroidism. Hypothyroidism is a disorder in which one is diagnosed for having and underactive thyroid. The probability for women over the age of sixty to develop an underactive thyroid is higher than those of other individuals. If left untreated it can potentially lead to obesity, joint pain, heart disease, and other health complications. On the contrary, hyperthyroidism is a disorder in which a person is diagnosed for having an overactive thyroid. This can cause nervousness and anxiety, hyperactivity, unexplained weight loss, and swelling of the thyroid gland which causes a noticeable lump to form on throat (known as a
One of the most common mysteries in the world is the development of autoimmune diseases. An autoimmune disease is when the immune system, which usually keeps your body healthy thinks that your healthy cells are antigens and attacks them. This is irony right? It is against properties of evolution for an immune system to attack itself causing sickness and possibly death if untreated. There are about 80 different types of autoimmune diseases, which usually have periods of little to no symptoms and worsening symptoms. What particularly creates confusion in the world is the autoimmune disease, inflammatory bowel disease, which affects almost about five million people worldwide.