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Genetics and its effects
Important of genetics to society
CONCULISION OF Gene therapy
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Recommended: Genetics and its effects
What is something we desperately cannot live without, something that courses through our bodies, keeping us alive, healthy, and alert? What is something that is often taken for granted in its role in deciding who lives and who dies? The answer: blood. It is often perceived that the blood’s only responsibility is that of gas transport to and from the tissues of the body; however, the blood is essential in keeping the body at the right homeostatic levels necessary for survival. Any imbalance in either a white blood cell or red blood cells’ ability to maintain homeostasis often results in severe disease within the host. Such diseases can sometimes be passed, genetically, from parent to offspring, or, at least, a predisposition to disease. Genetic defects in offspring often result from a spontaneous mutation in a parent’s gene, whose expression is necessary for survival, and then, after reproduction, the said affected gene gets passed to the offspring. Such genetic predispositions can result in disadvantages in those affected and present difficulties when trying to respond to or reverse the resulting disease. Hereditary spherocytosis and familial acute myeloid leukemia are two such conditions that affect normal red blood cell (RBC) and white blood cell (WBC) functions, respectively, that can also be passed from generation to generation. Currently, efforts to reduce the severity of these diseases, or potentially reverse them, involve the use of gene therapy in an affected individual. Modern gene therapy, very generally, involves replacing the mutated gene with a healthy copy of the gene, blocking the improperly functioning gene, or using another introduced gene to help fight a currently existing disease (INSERT CITATION). While gene t...
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...hin modern preventive medicine. The recombinant erythropoietin therapy in those affected by hereditary spherocytosis, which now is used to reduce severity of anemia and the frequency of transfusions, has laid the groundwork for further gene therapy techniques to reduce the severity of, or even reverse, the condition itself. The same foundation was laid by the researchers responsible for the determination of a safe recombinant purging of leukemia cells in those affected by familial acute myeloid leukemia and other types of myeloid leukemia. While therapy used to eliminate the transfer of affected genes from one diseased individual to their offspring remains a far-off concept, the research cited here provides affected families with the means to plan for their, and their children’s, future regarding a safe and effective way to respond to their genetic predispositions.
The mindset of every living organism is to survive and reproduce. As such, it may be surprising to hear that diseases actually plays a crucial role in the survival of our predecessors. In the book Survival of the Sickest, Dr. Sharon Moalem discusses the role these hereditary disorders played in keeping our very ancestors alive. Three examples mentioned in the reading selection include hemochromatosis, diabetes, as well as favism. All the diseases I mentioned had a specific aspect, to which I found particularly appealing. In the case of hemochromatosis, I found it intriguing how the author used his own life to draw a connection between the two traits. Dr. Sharon Moalem lost his grandfather to hemochromatosis and later was diagnosed with the
In the essay "Ethics in the New Genetics" by the Dalai Lama, the author states that before biogenetics may continue human beings must hold with them a "moral compass" that will protect all human beings from their fundamental characteristics to be taken away; the Dalai Lama hopes this will create more ethical decisions in the future. Similarly, in "Human Dignity" by Francis Fukuyama, the author examines the rise of human genetics and how it is going down a path that does not consider human essence, or in his words Factor X, as a legitimate attribute to all human beings as these biogenetics continue. The rise of biogenetics will create an unfair advantage to many, including farmers who will find that they must depend entirely on biotech companies
Every one in two thousand people are diagnosed with hereditary spherocytosis. This rare blood disorder is of the Northern European ancestry. The prevalence of hereditary spherocytosis in people of other ethnic backgrounds is unknown (Government). This disease should be detected in early childhood, but in some rare cases it can go undetected for years or never be detected at all. Hereditary spherocytosis not only affects the red blood cells but the spleen as well. It only takes one abnormal gene for a child to have the disease for the rest of his or her life. The disease is a reoccurring cycle, and this rare blood disorder is rare to the minds that do not have the disease, and to the minds that have not studied the disease. Although there is no definite cure a splenectomy will help maintain the disease. The million dollar question is “What is hereditary spherocytosis and is there a cure?”
There have been four somewhat recent successful gene therapy treatments. The four deal with correcting hemophilia, bone marrow transplants, skin cancer, and vessel growth. In the success with the bone marrow transplants, French researchers collected bone marrow cells from patients, used gene therapy to correct the bone marrow, and then returned the bone marrow to the patient. This was 80% successful as reports 16 months after the transplants showed. Squamous cell carcinoma, skin cancer of the head and neck, was treated using gene therapy as well. The fourth trial was where DNA was used to carry a substance that stimulates blood vessel growth to damaged heart tissue and in this trial there was much success noted.
Genetics can predetermine many things for an individual but health and prevention can aid in the prevention of the expression of some genes. This is why it is important for healthcare providers to promote their patient’s awareness of what he or she is at risk for so that they can live the healthiest life possible. It is much easier to prevent a disease than it is to cure one. As healthcare providers it is our responsibility to cure illnesses, sure, but more importantly it is our responsibility to prevent disease and increase our patient’s quality of
Scientists are also studying gene therapy as a good treatment for sickle cell anemia. One day, doctors may be able to stop the disease by changing or replacing the abnormal gene that causes sickle cell anemia.
Gene therapy is a technique which has developed in the wake of recombinant DNA (rDNA) technology. It is a process which results in the correction of a genetic disorder by the addition of a piece or fragment of DNA into the genetic material of a living, functioning cell. A mere thirty years ago this concept belonged to the realm of the human imagination made manifest in the works of science fiction. Today it belongs to the realm of the human imagination made manifest in the works of science, period. It is mind boggling to try to comprehend the far reaching effects of gene therapy. How is it affecting society? Who will benefit from its use? Should it be used at all? Should research continue? How do we answer all of these questions? The answers are not readily available, nor are they black and white, but an attempt at finding some solutions must be made. Before exploring this line of thought further, a basic understanding of the technical aspects of gene therapy is essential.
Despite being magical of gene therapy, it is high-risk. Few people got benefits from it, and it has a low rate of success. Prior to the human trial, Batshaw and Wilson had done experiment on animals to ensure the safety. Over 20 experiments have been done on mice but only 12 of them survived at last (Sophia, M. and Kolehmainen, J.D., 2000). More seriously, complicating diseases, which can be more dangerous than genetic diseases, might set in during the treatment period. In December 200...
America has been introducing foreign genes into cows, mice, sheep, and pigs for years; there is no reason that it cannot be done in humans as well (“Creating Designer Children”). Imagine parents picking their child out of a catalog instead of using God’s creation. (“Creating Designer Children”). Every child is born with the genes that are carried down the gene line of their family not by the parents picking how they want their child to be born. Genetic mutation is basically a future of designer children. Genetic mutation can cure the children of all diseases and traits that the parents do not want their child or children to have (“Creating Designer Children”). Around 1,000 to 4,000 children born in the United States will develop a disease before or around the age of 10 (“Creating Designer Children”). The question is, “will the child be born healthy or have problems later in life”? How far will parents and doctors go to engineer humans (“Creating Designer Children”)?
Epigenetics is the study of both heritable and non-heritable changes in gene translation, which do not stem from mutation. Epigenetic alterations to DNA may occur in several different ways; histone modification, DNA methylations, expression of microRNAs, and changes of the chromatin structure (Ntanasis-Stathopoulos et al). Depending on their presentation, they may be passed on to offspring. The exact mechanism of heritable epigenetic modification has not been discovered, but all of these alterations may have some impact on a wide range of disorders and have far reaching implications in the medical field. The study of epigenetics seeks to answer the age old question of whether nature or nurture is responsible for our phenotype, and it has arrived at the answer that in fact, both are. The discovery of epigenetic changes may lead us to cure many disorders, and even personality problems.
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Genes are made of DNA – the code of life (Gene Therapy- The Great Debate!). The changes in genes may cause serious problems, which we called genetic disorder. In theory, the only method to cure genetic disorders is gene therapy, which basically means the replacement of genes in order to correct the loss or change in people’s DNA. Although gene therapy gives patients with genetic disorders a permanent cure, it is controversial because it has safety and efficacy problems, and raises ethical issues.
Image what it would be like if doctors could cure Huntington's disease, muscular dystrophy, or even hemophilia. Could this be possible? With gene therapy this all could be reality in the near future. Gene therapy is a potential approach to the treatment of genetic disorders in humans. This is a technique where the absent or faulty gene is replaced by a working gene, so the body can make the correct enzyme or protein and consequently eliminate the root cause of the disease (BIO, 1990).
Gregor Mendel was an Austrian monk who revolutionized our understanding and perception of genetics. Mendel’s experiments in his monastery garden provided future geneticists with the basic principles of hereditary through the experimentation in both hybrid and pure bred pea plants, which he found to follow specific patterns in their offspring. The choice to use peas was because of their distinct varieties and their ability to produce offspring quickly and the ability to easily regulate fertilization simply with the use of a paintbrush. When conducting these experiments Before Mendel Pea Plant Experimentation it was commonly accepted that a child’s genetic traits were simply half from the mother and half from the father. This evidence was supported by experiments were generally conducted over a short period of time resulting in skewed and unreliable data, whereas Mendel’s experiments were conducted over an eight year period involving tens of thousands of plants. Two of Mendel’s traits that he focused on were the texture of the seed pod. E.g. smooth and round or wrinkled. In the first generation of these plants 100% of the pea plants possessed the Smooth and round texture. On the second generation of the pea plants of every 4 pea plants 3 posessed the smooth trait and a singular pea plant produced wrinkled seeds. Upon the review of his results Mendel concluded that characteristics could be expressed through dominant and recessive traits. The Dominant trait masks or completely covers the recessive, whereas a recessive gene is an allele that is only present in a homozygous genotype. Through Mendel’s experiments he proposed three principles of inheritance, whether you are looking at humans or pea plants, the apparent genetic traits t...
One of the biggest concerns involved in gene therapy in humans is the lack of knowledge and the possibility for consequences later on or i...