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Research paper on gene therapy
Conclusion on gene therapy
Essay on gene therapy
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Gene therapy is an innovative approach to treating and preventing disease (for example: cancer, viral infections, etc.), by replacing a mutated gene with a healthy copy of that same gene. The mere concept of gene therapy was first introduced to the scientific community in the early 1960’s and 1970’s, however it is still in its infancy1 as a medical practice. This technique is experimental and is not yet widely practiced yet in modern medicine because its efficacy is still being thoroughly worked on and investigated.
In the 1960’s and 1970’s, gene therapy was just a concept; an idea fostered by science fiction. However, in 1972, Theodore Friedmann and Richard Roblin published a paper proposing the idea that “ ‘good DNA’ could be used to replace defective DNA in people with genetic disorders”1. This approach to treating diseases was investigated and studied, and administered for the first time on a toddler (a four-year-old child) with a severe congenital immune deficiency (ADA deficiency) on September 14, 1990 by W. French Anderson and his colleagues.2 The patient’s disease, adenosine deaminase deficiency (ADA deficiency), is a congenital or inherited disorder that damages the immune system, leaves it vulnerable to the acquisition of other diseases, and eventually develops into severe combined immunodeficiency (SCID) which causes the individual to lack virtually all immune protection from bacteria or viruses. To help this patient, Anderson extracted white blood cells from the patient’s bone marrow and reinserted the normal genes which produce adenosine deaminase into her system.3 The procedure was successful, and as a result, 300 more clinical gene therapy trials were performed over the next ten years.2
Gene therapy has evolved ...
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...ene Therapy and Germ Line Gene Therapy. Retrieved from http://www.iptv.org/exploremore/ge/features/somatic.cfm
6: Williamson, R., & Kampmann, B. (1993). Retrieved from http://ec.europa.eu/research/biomed/therapy.pdf
7: University of Utah (2004). Exploring Gene Therapy. Retrieved from gslc.genetics.utah.edu/units/genetherapy
8: Bushelle, E., Hertz, E., Hubbard, D., Saylor, K., & Slyker, A. (2003). Technology of Gene Therapy:. Retrieved from http://www.macalester.edu/~montgomery/GeneTherapy.htm
9: Balan, S. (2011). Types Of Gene Therapy - Advantages And Disadvantages of Gene Therapy. Retrieved from http://www.biotecharticles.com/Biotech-Research-Article/Types-Of-Gene-Therapy-Advantages-And-Disadvantages-of-Gene-Therapy-1030.html
10: University of Utah (2014). Gene Therapy Successes. Retrieved from http://learn.genetics.utah.edu/content/genetherapy/gtsuccess/
"Mastectomy Surgery - Comparing Types of Mastectomies." About.com Surgery. N.p., n.d. Web. 15 Apr. 2014.
Gene therapy is the application of the technique where the defect-causing "bad" genes are replaced by correct "good" genes. The idea of gene therapy is to treat the disease by correcting the "bad" DNA (Deoxyribonucleic acid) rather than the current me thod of providing drugs, or proteins not produced by the defective gene. Gene therapy addresses the problem first hand by directly working with the genetic information causing the disease. From the book Shaping Genes, Dr. Darryl Macer says "It is like f ixing a hole in the bucket, rather than trying to mop up the leaking water." There are two kinds of gene therapy, somatic cell gene therapy and germline gene therapy.
There have been four somewhat recent successful gene therapy treatments. The four deal with correcting hemophilia, bone marrow transplants, skin cancer, and vessel growth. In the success with the bone marrow transplants, French researchers collected bone marrow cells from patients, used gene therapy to correct the bone marrow, and then returned the bone marrow to the patient. This was 80% successful as reports 16 months after the transplants showed. Squamous cell carcinoma, skin cancer of the head and neck, was treated using gene therapy as well. The fourth trial was where DNA was used to carry a substance that stimulates blood vessel growth to damaged heart tissue and in this trial there was much success noted.
It was in the 1980’s that scientist began looking at alternative ways of treatments, one is gene therapy. Scientist would insert human genes into a bacteria cell. Then the bacteria cell would transcribe and translate the information into a protein. Once that is done the scientist would then introduce the protein into human cells. Gene therapy can be simply viewed as inserting bits of foreign DNA into a patient’s tissue in hope...
Human gene therapy is a method used in the medical field that treats diseases at a molecular level, by solving the source of the problem; our genes. Today, diseases and disorders are commonly treated by solving the symptoms, the surface of the problem. Many disorders and diseases are caused by defective proteins and within those defective proteins are damaged and defective genes. These defective genes can be treated through gene therapy. Gene therapy is not new and has been developed and improved by researchers for the past couple years. Being an experimental technique, gene therapy also has its pros and cons, but so far is showing positive and rising success rates.
Gene therapy is a technique which has developed in the wake of recombinant DNA (rDNA) technology. It is a process which results in the correction of a genetic disorder by the addition of a piece or fragment of DNA into the genetic material of a living, functioning cell. A mere thirty years ago this concept belonged to the realm of the human imagination made manifest in the works of science fiction. Today it belongs to the realm of the human imagination made manifest in the works of science, period. It is mind boggling to try to comprehend the far reaching effects of gene therapy. How is it affecting society? Who will benefit from its use? Should it be used at all? Should research continue? How do we answer all of these questions? The answers are not readily available, nor are they black and white, but an attempt at finding some solutions must be made. Before exploring this line of thought further, a basic understanding of the technical aspects of gene therapy is essential.
Despite being magical of gene therapy, it is high-risk. Few people got benefits from it, and it has a low rate of success. Prior to the human trial, Batshaw and Wilson had done experiment on animals to ensure the safety. Over 20 experiments have been done on mice but only 12 of them survived at last (Sophia, M. and Kolehmainen, J.D., 2000). More seriously, complicating diseases, which can be more dangerous than genetic diseases, might set in during the treatment period. In December 200...
Lopez, Gerald Gabriel. "Gene Therapy: the Scientific vs. the Societal" The Resource. Jan. 1998. 10 Apr. 2001. .
In this paper, I will argue that genetic therapies should be allowed for diseases and disabilities that cause individuals pain, shorter life spans, and noticeable disadvantages in life. I believe this because everyone deserves to have the most even starting place in life as possible. That is no being should be limited in their life due to diseases and disabilities that can be cured with genetic therapies. I will be basing my argument off the article by “Gene Therapies and the Pursuit of a Better Human” by Sara Goering. One objection to genetic therapies is that removing disabilities and diseases might cause humans to lose sympathy towards others and their fragility (332). However, I do not believe this because there are many other events and conditions in society that spark human compassion and sympathy towards others.
"Institute for Responsible Technology." - 10 Reasons to Avoid GMO's. N.p., n.d. Web. 03 Dec. 2013.
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
(2013, 04). What are the types of genetic tests?. Your Guide to Understanding Genetic Conditions. Retrieved 04, 2014, from http://ghr.nlm.nih.gov/handbook/testing/uses
Property24. (2014). Pros and cons of buying and renting. Retrieved March 29, 2014, from http://www.property24.com/property101/rent-vs-buy-guide/pros-and-cons-of-buying-and-renting/17510
Safdar, M. (2010) Gene Therapy: Advantages and Disadvantages [Online] Available at: http://www.biotecharticles.com/Genetics-Article/Gene-Therapy-Advantages-and-Disadvantages-271.html [Accessed July 17 2011]
Preserve Articles. http://www.preservearticles.com/201012291888/disadvantages-of-free-trade.html. Accessed December 1, 2011. Net “Benefits of free trade” Economics Help http://www.economicshelp.org/trade/benefits_free_trade.html Accessed November 29, 2011.