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Relationship between food and cancer
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Cancer is perhaps one of the most irksome diseases whose causes are often elusive and unrecognizable. The etiological agents of cancer are difficult to estimate and it is not attributed to purely genetic or purely environmental factors, and therefore, cancer research has been largely focused on the interaction between genes and the environment (Mucci et al., 2001). A large number of studies have investigated the possible causes of various types of cancers, implicating diet, heredity and environment as its major determinants. Most diseases are a result of complex interactions between a person’s genetic make-up and the environmental agents he/she is exposed to (NIEHS, 2011). Therefore, the possibility of the involvement of gene-environment interactions in the occurrence of cancers is being investigated worldwide.
Gene-Environment Interactions
A disease occurs when there is an interaction between “genetic susceptibility factors” and “modifiable environmental factors”, and variations in the genetic make-up of an individual influence his/her susceptibility to environmental factors that are responsible for a disease (CDC, 2000). Therefore, owing to genetic variation, some individuals are more susceptible to a particular disease than others are, and these variations govern the extent of effect a particular environmental condition has on the risk of a disease in an individual.
Can Gene-Environment Interactions be Measured?
Gene-environment interaction can be defined as that which occurs when a “genetic and environmental exposure work together to cause a disease outcome in some or all cases” (Brennan, 2002). Since the genetic make-up of an individual determines the susceptibility to environmental carcinogens, researchers are toiling t...
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...y Program, U.S. Department of Health and Human Services. Retrieved September 7, 2011, from http://ntp.niehs.nih.gov/ntp/roc/twelfth/roc12.pdf
Travis, R. C., Reeves, G. K., Green, J., Bull, D., Tipper, S. J., Baker, K., Beral, V., et al. (2010). Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study. Lance, 375(9732), 2143-2151. Lancet Publishing Group. Retrieved September 7, 2011, from http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60636-8/abstract
Zhou, W., Liu, G., Miller, D. P., Thurston, S. W., Xu, L. L., Wain, J. C., Lynch, T. J., et al. (2002). Gene-environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancer. Cancer Research, 62(5), 1377-1381. Retrieved September 7, 2011, from http://cancerres.aacrjournals.org/content/62/5/1377.short
ED. Mayo Clinic Staff -. Mayo Foundation for Medical Education and Research, 05 Jan 2012. Web. The Web.
1-34). The. San Francisco, CA: Jossey Boss. The American Public Health Association. (2003). The 'Secondary' of the 'Secondary'.
Health, U.S. Department of Health and Human Services Office of Minority. "U.S. Census Bureau Report." 2007. OMH - Office of Minority Health. 3 December 2011 .
Linderman, Robert, Charles Mouton, and Melissa Talamantes. "Health and Health Care of Hispanic/Latino American." Stanford University. N.p., n.d. Web. 27 Apr. 2014. .
Breast cancer is the second leading cancer to cause death in women. A combination of factors contributes to the etiology of breast cancer, such as genetic and environmental dynamics [ACS, 2014]. One particular area of interest is the study of metalloestrogens, which are inorganic compounds that can bind to the estrogen receptor and mimic the biological functions of estrogen in breast cancer cells. Arsenic is one such metalloestrogen and has been classified as carcinogenic to humans [IARC]. Studies in humans have shown that long-term exposure to arsenic is associated with bladder, kidney, lung and liver cancers [1,2,3]. Arsenic exposure has also been correlated with an increase in the incidence of breast cancer [4]. People can be exposed to arsenic in different settings such as in the workplace, in drinking water or from medical treatments. Through these methods of exposure, various mechanisms of internalization can take place through inhalation, ingestion, or through skin contact. We hypothesize that prolonged arsenic exposure results in the expression of genes that promote breast cancer progression. In this study, we propose to investigate the effect of prolonged arsenic exposure on gene expression, by comparing the global gene expression of a breast cancer cell line that has been chronically exposed to low-dose arsenic with that of a control cell line. Genes found to be differentially expressed in arsenic adapted cells will be examined further. We also aim to extend our understanding of the direct effect of arsenic, by studying the signal pathway that results in gene expression when arsenic binds to the estrogen receptor.
US Department of Health and Social Services, Healthy People 2010, 2nd Ed., US Gov. Printing Office, 2000.
Cohen, S. (2013, January). Student Health 101 @ Ashford University. Retrieved April 1, 2014, from http://readsh101.com/ashfordu.html?id=ec8bd17d
Page-Reeves, J., Niforatos, J., Mishra, S., Regino, L., Gingrich, A., & Bulten, J. (2011). Health
My sister, Kathy, was diagnosed with cancer in 2013. I was shocked because my sister was always the healthy one among all us girls, the type of cancer, Kathy called colon cancer, Cancer that forms in the tissues of the colon. Most oncogene mutations of indisputable normal genes designate proto-oncogenes. Proto-oncogenes determine the “excellent” genes that usually rule what cell do and the way typically it distribute. Once a factor mutates (changes) into cell, it come back a "hurtful" factor that may become usefulness on or activated once it's not believe to be. Once this occurs, the cell becomes out of management, which might pass to cancer. As scientists learn additional throughout oncogenes, they will be powerful to develop a medication that inhibits or restrain them.
Retrieved August 20, 2010 from http://www.kff.org/healthreform/7920.cfm
Processes of exogenous and endogenous are likely to result in mutated genes leading towards cancer. (Schulz 2005, Knowles & Selby 2005). There are three known classifications of carcinogens, which are described to be cancer-causing agents based on the fact that they directly boost effects and thus cause mutations of the alterations already in place. The three classifications include: Chemical carcinogens which can be related to cigarettes and the mutations created as a result of the chemicals involved; Physical carcinogens which involves...
Young, S. (2011, December). Report: Certain environmental exposures can increase breast cancer risk. CNNHealth.com. Retrieved March 31, 2014, from www.thechart.blogs.cnn.com/2011/12/07/iom-certain-environmental-exposures-can-increase-breast-cancer-risk/.
The American Cancer Society publishes current advances made in cancer research on their website. Many of the exciting discoveries about how best to treat the disease focus on the genetic aspects associated with certain types of cancer. In addition, treatments aimed at genetic solutions to cancer may be more effective and may cause fewer adverse side effects than traditional cancer treatments (American Can...
Since she was trained as a biologist therefore she started to look for answers in previous scientific research. One of the obstacles that prevent us from addressing cancer’s environmental roots is the word lifestyle. Risks of lifestyle are not independent of environmental risks. Our lives are played out within the ecological world…” (pp.270) comes from her personal experience as she states that we tend to ignore the risks that ou...
American Journal Of Public Health103.1 (2013): 27-31. Business Source Premier.