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Describe autism spectrum disorder
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Gender Causes And Effects Of Autism Spectrum Disorder
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Recommended: Describe autism spectrum disorder
Autism is significantly caused in people by de novo mutation, deletions, duplications, genomic rearrangements, or point mutations in the germ line of one parent that causes loss of function or gain of function to a large number of genes. This can occur in any family with any genetic background and can appear in any offspring, regardless of gender. Offspring’s with mild disorders (asymptomatic carriers) i.e., females may marry and have children who inherit mutations in a dominant way. It is now obvious that the third-born male child is at high risk, i.e., his probability of being affected in comparison to the first two children being affected is nearly 50% with dominant transmission and high penetration. Females are at lower risk (20%) with lower incidence in females and reduced penetration in that gender. Explanation is yet to be given about disruptions on a single chromosome with incomplete penetrance that creates carrier states. [30] Females are resistant and therefore make logical carriers, but discordance between monozygotic twins suggest Autism Spectrum Disorder genotype and exi...
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