GRADE Etd Framework

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For example, for the antithrombotic guideline, the systematic review on utilities suggested that major bleeding was equivalent to nonfatal pulmonary embolism; while intracranial bleed overall was 2 to 3 times worse than major bleed or pulmonary embolism [37]. In the Breast Lump guidelines we found that recurrence and metastasis are the most important outcomes for women, and were considered as such by the panel [36].
How consideration of local values and preferences influenced recommendations
The presumption that local values and preferences differ from those obtained in other settings, questions the usefulness of using the latter. In several cases, local values and preferences contributed significantly to the formulation of recommendations. …show more content…

The Saudi Arabian panels weighted the relative importance of outcomes using information from literature reviews, the panel members themselves, and patient representatives. This facilitated adoption, adaptation and creating new recommendations according to local values. The GRADE EtD framework helped facilitating the use of values and preferences information in the decision making process by explicitly calling attention to the criterion when balancing benefits and harms. The approach we used has face validity because the panel members did not identify missing studies on local values and preferences. As guideline methodology is refined, how to define, measure, and incorporate patient values and preferences will evolve.
There are other guideline efforts that consider patient values and preferences in the process of developing recommendations. For example, the National Institute for Health and Clinical Excellence (NICE) also considers the impact of values and preferences on the strength of recommendation. The process includes asking patient representatives to reveal their experience in addition to reviews of qualitative research evidence and cross-sectional surveys. However, NICE does not operationalize values and preferences as the importance of outcomes

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