Plasmodium falciparum, this is the most deadly out of all 4 to humans this lies in the salivary glands of the mosquito and it is transmitted to humans by the females of the Anopheles of the mosquito. As the mosquito takes the blood from the human during the process it only injects a tiny amount of its saliva into the skin wound, with this the saliva has antihemostatic molecules and anti-inflammatory enzymes within it which slow the body’s natural blood clotting process and produces the itching/stinging pain.
There are few animals in the world that have as medically significant biology as mosquitoes. Carrying diseases that annually kill thousands, if not millions, of people worldwide, mosquitoes and the way they interact with pathogens are topics of concern for many researchers. As invertebrates, mosquitoes possess various immune responses designed to rid themselves of pathogens. Study of these immune responses has led to a deeper understanding of the ways in which the immune cells of mosquitoes, hemocytes, function and serve the purpose of killing the invasive pathogen. In conjunction with the circulatory system of the mosquito, these immune cells react in various ways upon infection with a pathogen such as a bacterium or virus. The Hillyer Lab
When a female Anopheles mosquito ingest blood the containing sexual stage of the parasite(gametocytes),male and female gametes unite in the mosquito stomach to form the ookinate,this penetrates the stomach wall to form the cyst on the outer surface in which about a thousand sporozoites developed:this required 8-35 days. Sporozoites will be penetrate the wall of oocyst reach delivery gland and are infective when injected into a person,as the insects take its next blood meal. In the susptible host,sporozoites enter hepatocytes and develop into exo-erythrocytic schizonts. When these mature,the infected hepatocytes rupture:asexual parasites reach the bloodstream and invade the erythrocytes to grow and multiply cyclically. Most will develop into asexual forms,from trophozoites to mature blood schizonts that rupture the erythrocyte within 48-72 hours,to release 8-30 erythrocytic merozoites that invade other erythrocytes. At the time of each cycle rupture of large numbers of erythrocytic schizonts induces clinical symptoms.
Malaria is a disease which effect both humans and animals and it is caused by the spread of the Plasmodium parasite. This parasite uses the female Anopheles mosquito as vector in order to infect a human or animal with the parasite; when a person is bitten by an infected mosquito, sporozoites enter the blood and travel to the liver. In the liver they divide to become merozites which then move back into the bloodstream where they infect red blood cells. In the red blood cells they divide further, exploding from the cells every 48-72 hours causing waves of illness. The infected human is then bitten again and the mosquito takes up the merozites and goes on to affect another.  This is also shown in figure 1.
Man can capture an elephant, train a lion, and totally obliterate a species from this earth. If man can do all that surely he will have dominion over something as small and meek as a mosquito. The Yellow Fever epidemic of 1793 proved this notion to be false as this disease, transmitted solely by the bite of a female mosquito, wiped out one tenth of Philadelphia’s population in four months. Some make the mistake of seeing this as an isolated event but this epidemic was as far-reaching as the disease itself since it forever changed America’s Government, public health system and African American community.
Living in the world that consists of three thousand different types of mosquitoes is frightening. People got used to a daily routine of waking up and getting to their jobs, that many of them are so focused on their career and family that they do not even notice and pay much attention when they are getting bitten by mosquitoes. Unfortunately not many people were aware of the fact that not all insects are safe, many of mosquitoes transfer infections, but we were not concentrating on that since it was considered not a common issue. As a repercussion, people did not begin to react and notice that something wrong with them when Aedes mosquitoes began their attempt on ruining people’s social, physical and psychological lives by transferring a Zika virus to the once who are bitten.
My curious readers, I must emphasize the fact that per my own observations, up to 80% of those persons bitten by an infected mosquito will be asymptomatic and thus will have nothing to worry about. Yet those who develop what we are currently calling the "mild symptoms" of the virus, may exhibit any combination of the following symptoms: fever, headache, nausea, vomiting, skin rash, and swollen lymph glands. One will exhibit any or all of these wretched symptoms, which I myself have observed to last no more than a few days.
P. falciparum is a protozoan parasite that once it has infected its human host causes the disease known as Malaria (Lehne, 2013, p.1238). This particular species of the genus Plasmodium is believed to stem from over one hundred thousand years ago (Carucci, 2004). These protozoan parasites are transferred to the human host by way of a vector in the form of a female Anopheles where the parasite resides in the saliva and is released when the insect feeds on a humans blood (Miller et al., 2013). The mosquito acquires this parasite by the same means of feeding on an infected host where the protozoa is ingested, grows and multiples in the stomach and upon maturation it shifts to the salivary glands to be spread to the next human host (Kyes, Horrocks, & Newbold, 2001).
In their article, “The Six-Legged Meat of the Future,” Dicke and Van Huis argue that due to the decline in the supply of meat in America, we should begin to use insects as an “alternate animal protein”
The life cycle of T. cruzi: The vector, reduviid bug, bites and defecates on host. Parasites, in the form of trypomastigotes, are able to enter the blood via mucous membranes or a cut. During cell invasion, the trypomastigotes transform into amastigotes and undergo multiplication. Parasites are then released into the blood stream as trypomastigotes where they either spread to other tissues or are taken up by the vector to perpetuate the life cycle2.