Essay On Vasculitis

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Vasculitis refers to a heterogeneous group of disorders that is characterized by inflammatory destruction of blood vessels. Inflamed blood vessels are liable to occlude or rupture or develop a thrombus, and thereby lose the ability to deliver oxygen and other nutrients to tissues and organs. Depending on the size, distribution, and severity of the affected vessels, vasculitis can result in clinical syndromes that vary in severity from a minor self-limited rash to a life-threatening multisystem disorder 1. Because it often begins with nonspecific symptoms and signs and unfolds slowly over weeks or months, vasculitis is one of the great diagnostic challenges in all of medicine. Yet, physicians who know the general and specific clinical clues for vasculitis can often learn to suspect when vasculitis is present at the bedside. Establishing the diagnosis of vasculitis requires confirmation by laboratory tests, usually a biopsy of an involved artery but sometimes an angiogram or a serologic test 4, 5. The demographic and epidemiologic characteristics of vasculitic disorders vary greatly by geography. This variation may reflect genetics, environmental differences, and the prevalence of other risk factors.7 Although some patients with vasculitis are seen by other specialists (dermatologists, pediatricians, internists), only patients who were seen and managed by a rheumatologist were recruited in our study. Thus, some forms of vasculitis (e.g. IgA vasculitis, cutaneous leukocytoclastic angiitis, and Kawasaki’s disease) may be underestimated. Vasculitis may occur as a primary process or may be secondary to another underlying disease 4. We studied only patients with primary vasculitis; patients with secondary vasculitis were not included. ... ... middle of paper ... ...temic vasculitis in children 17. Ninety percent of cases are in the pediatric age group. There is a male predominance with reported male-to-female ratios of 1.2:1 to 1.8:1 18. IgA vasculitis in our study was as frequent as ACR study 8, but much lower than Denmark study. In our study, it was slightly more common in males (1.2:1). Cutaneous leukocytoclastic angiitisis (hypersensitivity vasculitis) is a clinical term that generally refers to an Immune Complex -mediated small vessel vasculitis of the skin that spares internal organs and usually follows drug exposures or infections 19. It was the second most common type of vasculitis in our study (8.2%). The frequency of Cutaneous leukocytoclastic angiitisis in population of Denmark 10 is much higher than population of northeast of Iran (table 2). We found a male: female ratio of 0.8 to 1 and the mean age was 38 years.

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