1. Nanomagnetic-supported sulfonic acid is found to be a powerful and reusable heterogeneous catalyst for the efficient synthesis of Pyrimidinones. In this study we use various ketones such as acetophenone and cyclopentanone in one-pot synthesis of Pyrimidinones. Our objective is to improve conditions for the synthesis of multicomponent reactions using nanomagnetic catalyst under solvent free condition. A Number of excellent and significant results have been developed that lead our perspective understanding of the effect of the magnetic nanoparticles when they are used as catalysts. 2. Nano-materials, including their use as catalysts, are important in many diverse areas. For example, they can act as a heterogeneous catalyst and act as a contact between the reactants and the catalyst itself. The largest problem to be considered results from the difficulty of their separation. The process of separation is accompanied either by filtration or centrifugation; in these processes there is a substantial loss of nanocatalyst that cannot be avoided. As a new technique, nano magnetic catalyst, is used to solve this problem and has the same excellent performance. At this juncture, the recovery of catalyst from the reaction is done, using an external magnet. Recently, the use of magnetic iron nanoparticles, as catalysts, has been under intensive investigation for various organic transformations [1-3]. Environmental protection is an important …show more content…
At first glance, we decided to use ketones instead of β-ketoesters, which gave us the opportunity to prepare corresponding new 3, 4-dihydropyrimidin-2-(1H)-ones. The Biginelli type reaction of ketones with a single carbonyl group provides a useful 3, 4-dihydropyrimidin-2-(1H)-ones. In order to optimize conditions the reaction of benzaldehyde (1mmol), acetophenone (1mmol) and urea (1.5mmol) under solvent free condition and 80 °C was chosen as a model system under thermal conditions. This system was tested with nano-γ-Fe2O3-SO3H (Scheme