Essay On Blood Coagulation

explanatory Essay
2315 words
2315 words

Does Hypothermia Affect Blood Coagulation Enzyme Activity?

Blood coagulation:

Blood coagulation is a cascade of events that help heal a cut or damaged tissue; it is part of a host defense mechanism termed hemostasis [1] When a vessel, or damaged tissue is affected, macromolecules called platelets are introduced (Sticky molecules that assist to clot a cut to allow blood to once again pass) – With fibrin and plasma to help heal. Of course, there needs to be no abnormalities, such as temperature. A type of stroke bleeding is termed hemorrhage, caused by trauma. When blood from trauma irritates brain tissues, it causes swelling [2] In order for a blood clot to occur it requires enzymes to activate other enzymes: TF (Tissue Factor) Serine proteases (Enzymes) such as FVII and FV glycoproteins.
We can then observe whether temperature can affect the coagulation of cascade.


There are the three pathways in which coagulation occurs: Intrinsic, Extrinsic and Common. The intrinsic pathway is once a substance within the vessel wall (collagen that ordinarily hidden from the blood however exposed if the vessel is damaged) meets a unique chemical within the blood (Factor XII) a series of chemical changes occur that end in the formation of protein and a blood clot. The foreign pathway is ready in motion once blood leaves a broken vessel and enters the tissues around it. Then a chemical within the blood (Factor VII) comes into contact with a chemical within the tissues (Tissue Factor). Once these 2 rest a series of chemical changes occur that results in the formation of protein and a blood clot.


Hypothermia, a doubtless fatal condition, happens once blood heat falls below 95°F (35°C). Although physiological condition is a ...

... middle of paper ...

...hermore, some studies suggest that even though the hypothermia period was relatively short, haemostatic mechanism was impaired. Data indicate an increased thrombotic and fibrinolysis tendency. Major trauma and abdominal surgery are related to hypothermia, usually of duration longer than 60 minutes [22] Overall, this case study shows the enzyme activity and how serious it is; using one country as an example that can also be related to others, around 140 Canadians and 800 Americans die each year as a result of hypothermia [26] The whole idea of blood unable to clot as fast as it can will lead to trauma and strokes and brain injuries and is much more lethal than what it seems. Overall, the enzyme activity may not be dramatically decreased but it is enough to kill a human and it is now proven that the enzyme activity is affected by hypothermia and this is a big deal.

In this essay, the author

  • Explains that blood coagulation is a cascade of events that help heal cut or damaged tissue.
  • Explains the three pathways in which coagulation occurs: intrinsic, extrinsic and common.
  • Explains that hypothermia is a fatal condition that occurs when blood heat falls below 95°f. the victims are typically homeless male alcoholics.
  • Explains that hypothermia is divided into two types: primary and secondary. primary physiological condition involves exposure to cold air or immersion in cold water.
  • Explains the signs and symptoms of physiological condition, which vary from person to person depending on age, health, and alternative factors.
  • Explains that hypothermia affects the clotting factor activity. six healthy volunteers collected blood using a thromboelastograph.
  • Explains that unknown bleeding could occur during surgery or liver transplantation.
  • Explains that many people with hypothermia suffer from trauma which decreases fibrin concentration, which thrombin breaks down to make. some patients are placed in normothermic conditions and this changes the rate of enzyme activity.
  • Explains that therapeutic hypothermia is a medical treatment that can lower the patient's body temperature to reduce the risk of injury (ischemic).
  • Opines that hemicraniectomy is allowed to be used with someone with hypothermia, and that it can help and normalize coagulation function during the procedure.
  • Explains that hypothermia affects blood coagulation, but there are no studies using whole blood analysis that have evaluated the effects of it.
  • Explains that the thromboelasto graph has a sensor that blood is placed in usually 0.36ml. the speed and strength of clot formation is measured in various ways.
  • Explains that prothrombin time and partial thromboplastin time determinations were only minimally shortened at hyper thermic temperatures. the enzymatic reactions of the coagulation cascade are strongly inhibited by hypothermia.
  • Explains that mild hyperthermia has the highest plasma concentration, while moderate has dramatically fallen, lowering the body temperature. this indicates a lack of enzymes being activated by its complementary need.
Get Access