Understanding the activation of inflammation, coagulation and fibrinolysis in the pathophysiology of sepsis, has allowed further research and development of therapeutic agents in its clinical treatment (Della, 2012). In response to pathogens infecting the body, leukocytes release cytokines, some examples are interleukin-1, 6 and tumour necrosis factor α (Bernard, 2001). These can cause extensive activation of coagulation and decreased fibrinolysis; thus the equilibrium of the body normally regulated by homeostasis is altered (van Deventer, 1990). Coagulation is activated by stimulating factors leading to the generation of thrombin. Thrombin can stimulate inflammatory pathways, thus reducing fibrinolysis further.
The aim of this study was to determine the putative colon cancer stem cell subsets in human colon cancer cell lines HCT116 and HT29, which differ in their aggressiveness and differentiation capacity. Material and methods. Flow cytometry was used to asses HCT116 and HT29 cell lines for the expression of stemness-associated surface markers CD24, CD44, CD117, CD133, ESA, ABCB1. Both cell lines were treated with 5-fluoruracil and the phenotype of chemoresistant cells was investigated. Side population was visualized via Rhodamine 123 staining.
), Frontiers of cord blood science (pp.307-315). London: Springer. ViaCord. (2012). Treatable diseases and future uses of cord umbilical cord blood stem cells.
Cardiovascular disease is one of the leading deaths in the United States. Pulmonary hypertension disease one type of cardiovascular disease that is due to the narrowing of the arteries within the lungs. When the arteries are narrowed the right side of the heart is unable to pump blood through the lungs, pressure begin to build up and not enough oxygen is being picked up, therefore causing pulmonary hypertension. If there are damages to the endothelium, it can cause this disease because it can produce more endothelin-1, which is one of the isomer of Endothelin that influence as a vasoconstrictor. Introduction It is important to have treatment available to patients who suffer from cardiovascular diseases.
Corrigendum to:‘‘EASL clinical practice guidelines: Management of chronic hepatitis B virus infection’’[J Hepatol 2012; 57: 167--185]. Journal of Hepatology. 2013;58:201. 3. Scaglione S, Lok A.
This project will compare the relative toxicity of myeloablative allogenic peripheral blood stem cell transplantation (PBSCT) and non-myeloablative PBSCT. This will involve collecting patient serum samples at various time intervals during treatment. The samples will be evaluated for TNF-a concentrations using the ELISA technique. The data will then be used to determine the toxicity of each regimen. This study will p... ... middle of paper ... ...ne response.
Leukemia is a disease that can cause death. Leukemia is defined as the type of cancer in the blood cells that causes the cells to work improperly, usually affecting the white blood cells. It occurs when an abnormal increase of immature blood cell is produced compared to mature blood cell. Large numbers of abnormal blood cells produced caused the bone marrow to contain more abnormal cell, thus causing difficulties for normal cell to survive. This disease spread among the cells without control and can cause a major death to the patients.
Silini, A., et al., Regulator of G-protein signaling 5 (RGS5) protein: a novel marker of cancer vasculature elicited and sustained by the tumor's proangiogenic microenvironment. Cell Mol Life Sci, 2012. 69(7): p. 1167-78.
Stem Cell-Based Therapies: Promises, Obstacles, Discordance, and the Agora. Perspectives in Biology and Medicine, 55(1), 1-25. Serup, P. S. (2001) Islet and stem cell transplantation for treating diabetes. Development of biology, 322(6). 29-32 Han, J. H., and Sidhu, K. S. (2011).