Effect of monomer modification on the physico-chemical properties, degradation and in vitro biocompatibility of polyester bioelastomers
2036 Words9 Pages
A careful selection of monomers for biomaterial syntheses is essential for determining and controlling the functionality and biocompatibility of the biomaterials to be produced. Synthetic polyester elastomers based on molecules that are endogenous to the human metabolism have been designed . In earlier studies, several investigators have reported elastic polyesters based on citric acid, in particular polyoctanediol citrate (POC) , poly(alkenylene maleate citrate) , poly(xylitol-co-citrate)  and poly(mannitol citric dicarboxylate) . Although a number of biodegradable elastomers have been developed, most of them require complex and expensive synthetic procedures, which translate into higher manufacturing costs and hinder the commercial and clinical implementation of their use in tissue engineering . Also, as more stringent material requirement in tissue engineering is made, there is a continuous need for newer materials’ design and synthesis . The objective of the present work is to design polyesters using citric acid, sebacic acid, itaconic acid and 1,12-dodecanediol. To synthesize the polyesters by melt condensation, thermal polyesterification technique without using catalysts or coreagents, making this method attractive for the synthesis of polyesters useful in medical applications. The chosen monomers are expected to provide the polyesters with physico-chemical properties that could be significantly impact the degradation and biocompatibility of the synthesized polyesters.
Materials and Methods
Results and Discussion
Synthesis and Characterization of the polyesters
The copolyesters were synthesized by melt condensation of monomers based on the schematic representation in Figures 1a and 1b.
The FT-IR spectra ...
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