Effect of Glucose Levels on the Brain

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Although it constitutes only 2% of the body’s weight, the brain uses approximately 75% of the glucose in the blood, making it the by far the most metabolically expensive organ in the human body (Dunbar, 1998; Kahn, 2005). Glucose (the main type of sugar in the blood) is the primary source of energy for the brain and for the rest of the body. When glucose levels are high, excess glucose is converted and stored as glycogen, which can later be metabolically converted back to glucose and used for energy.

The energy cost is especially high for mental tasks that recruit the “central executive,” or the areas of the brain that regulate cognitive and emotional control. These tasks reduce blood glucose levels at higher rates than other mental tasks which do not recruit the executive (Galliot & Baumeister, 2007). In addition, many tasks which would seem to require self-regulation and executive function suffer when glucose is depleted, and can show improved performance if glucose levels are restored. Such tasks include avoiding prejudiced or stereotype-driven behaviors (Galliot et al., 2009), being willing to help strangers (DeWall, Baumeister, Galliot, & Maner, 2008), attention-tracking performance in a dual-task situation (Scholey, Sunram-Lea, Greer, Elliot, & Kennedy, 2009) memory (Meikle, Riby & Stollery, 2004), complex decision-making (Masicampo & Baumeister, 2008); and persistence in difficult tasks (see Galliot, 2008 for a review).

Most previous studies have used social-cognition procedures that intuitively seem to require executive processing, but that do not have a direct, controlled comparison between executive and nonexecutive-demanding conditions. Therefore, it is not clear whether glucose has its primary effects on ex...

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...gulation, and Word Imagery Value on Human Memory. Behavioral Neuroscience, 113, 431-438.

Scholey, A.B., Sunram-Lea, S.I., Greer, J., Elliot, J., & Kennedy, D.O. (2009). Glucose administration prior to a divided attention task improves tracking performance but not word recognition: evidence against differential memory enhancement? Psychopharmacology, 202, 549-558.

Scholey, A.B., Sunram-Lea, S.I., Greer, J., Elliot, J., & Kennedy, D.O. (2009). Glucose enhancement of memory depends on initial thirst. Appetite, 53, 426-429.

Scholey, A.B., Harper, S., Kennedy, D.O. (2001). Cognitive demand and blood glucose. Physiology & Behavior, 73, 585-592.

Sunram-Lea, S.I., Foster, J.K., Durlach, P., & Perez, C. (2002). The effect of retrograde and anterograde glucose administration on memory performance in healthy young adults. Behavioural Brain Research, 134, 505-516.

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