Ecstasy: Neurotoxicity and How It Can Be Reduced
Ecstasy (MDMA) has become a drug of choice among 18-25 year olds (2), and its effects on behavior and neurotoxicity merit the attention of this class. Ecstasy use has become fairly widespread on college campuses and in rave and nightclub settings. This paper will look at the mechanism through which MDMA acts, its neurotoxicity, and how users can reduce risk involved with ecstasy use.
Ecstasy alters behavior by increasing serotonin levels in the brain. It accomplishes this by altering the neurotransmitter serotonin's reuptake process. (6) In the normal serotonin system, a serotonin neuron will receive a signal from a neighboring nerve cell to release vesicles of serotonin into the synaptic cleft. The post-synaptic cell (which has the appropriate receptors for serotonin) then picks up the molecule. When the serotonin binds to the receptor, it causes an electric signal to change the membrane permeability which causes changes in the body. When a vesicle of serotonin is released, most of the molecules are pulled back into the pre-synaptic cell. This process of drawing serotonin back into the original neuron for it to be reused is called reuptake. When MDMA is present in the system, however, it interferes with the natural process by preventing the serotonin from entering at the reuptake site. This causes an excess of serotonin in the system, which creates the feelings of euphoria associated with MDMA. (1)
Users of MDMA are quick to praise the psychological effects of the drug, but the effects on their physical health can be detrimental. Studies show that heavy, prolonged use of MDMA can significantly reduce the number of serotonin transporters which are necessary to bring the neurotransmitter back to the neuron from which it was released. Studies supported by the National Institute on Drug Abuse (NIDA) showed that MDMA damages neurons that release serotonin, and that heavy MDMA users have lingering memory problems for at least two weeks after stopping the drug. In the first study, researchers used positron emission tomography (PET) to compare the brains of MDMA users who had abstained from all psychoactive drugs for three weeks and people who had never used MDMA. They found that the amount of MDMA used was directly linked to the number of serotonin transporters remaining. They also found that the degree of memory impairment is based on the amount of MDMA used. (3)
After smoking, or consuming marijuana, it is distributed in the brain. The concentration of marijuana in the brain may be governed by an active transport process in the choroid plexus network of blood vessels in the brain which regulates intraventricular pressure by absorption and secretion of cerebro spinal fluid. one scientific experiment it gave an example of how the distribution of marijuana in the central nervous system could effect man. At a high dose of 30 mg./kg. marked sedation and pronounced motor incoordination peaked at the one hour interval subsiding in 8 hours when over reaction occurred to external stimuli; man reveals incapacitation of cognitive and motor function. High concentrations of marijuana are usually found in the following parts of the brain: the frontal cortex (the general association area), and hippocampus (short term memory and oreintation). As a result, perception of time, mood and general cordination is impaired. It is apparent that marijuana intoxication effects the neurological functions and usually disappears in 24 hours, but can become a permanent malfunction.THC effec...
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Boeri, M. W., C. E. Sterk, and K. W. Elifson. "Rolling beyond Raves: Ecstasy use outside the Rave Setting." Journal of Drug Issues 34.4 (2004): 831-860. Sage Journal. Web. 20 Apr. 2014.
Based on the case study provided: Hospital A, Porter Regional Medical Centre (Hosp. A) & Hospital B Banner Regional Medical Centre and Turner Geriatric Centre (Hosp. B) merged to form a consolidated entity named “Portsmith Regional Medical Centre” (PRMC). Both Hospital A and B were fully accredited hospital, with “state-of- art diagnostic technology” which included MRI and CAT scanners, 24-hour physician staffed emergency centers. Both Hospital A and Hospital B are located in a small community of 60,000 people in southeastern part of Idaho.
Wilson, R. (2009). A lifetime of student debt? Not likely. In G. Graff, C. Birkenstein, & R. Durst (Eds.). “They say, I say”: The moves that matter in academic writing with readings. (2nd ed.). (pp. 256-272). New York: W. W. Norton. This article examines how much debt in loans students leave college with and if it is possible to pay it off without it causing extreme distress.
"Cocaine delivers an intensity of pleasure - and despair - beyond the bounds of normal human experience."
Niles, N. J. (2011). Basics of the U.S. health care system. Sudbury, MA: Jones and Bartlett.
Goldberg, J. (2012, October 10). Drug abuse, addiction, and the brain. In Mental Health Center. Retrieved November 13, 2013, from http://www.webmd.com/mental-health/drug-abuse-addiction?page=3
Since memory and pleasure zones are intertwined in the brain, many researchers have been using psychological approaches to stop drug use.
Feldstein, J.P. (2011). Health Policy Issues: An economic perspective (5th ed.). Chicago, IL: HAP &AUPHA.
The most commonly abused substances are Nicotine, Inhalants, Alcohol, Cocaine, Amphetamines, Prescription medications, Heroin, Ecstasy and Marijuana. 1a(National Institute on Drug Abuse, 2011) Initially, a person may find themselves using substances voluntarily and with confidence that they will be able to dictate their personal use. However, over the period of time that drug use is repeated, changes are taking place throughout the brain, whether it is functionally or structurally. Drugs contain chemicals that enter the communication system of the brain and disturb the way in which nerve cells would typically send, receive, and process information. The chemicals within these drugs will cause a disruption to the communication system by either imitating the brain’s natural chemical messengers or by over-stimulating the brains “reward system” by sending mass amounts of dopamine. As an individual prolongs his or her use of these substances, they may develop an addiction.
Leinwand, Donna, Marisol Bello, and Martha T. Moore. "In Haiti, Children Are the Most Vulnerable - USATODAY.com." In Haiti, Children Are the Most Vulnerable - USATODAY.com. USA TODAY, 25 Jan. 2010. Web. 26 Apr. 2014.
Watanabe-Galloway, S., Ryan, S., M.D., Hansen, K., M.P.H., Wullsiek B., B.A., Muli, V., M.P.A., & Malone, A.C. (2009). Effect of Methamphetamine abuse beyond individual users Journal of Psychoactive Drugs, 4131, 241-8.Retrieved from http://search.proquest.com/docview/207970885?accountid=41057
The altered states of consciousness produced by drugs presents an all-to-common phenomenon in today’s society. Whether the desired sensation comes in the form of energy, a means of relaxation, or pain reduction, many people go to great lengths and present their bodies to threatening conditions in order to achieve this euphoric “high.” Unfortunately, the use of these drugs very often comes with dangerous side effects that users must learn to manage with for the rest of their life. According to neuroscientists, our entire conscious existence bases itself off of the lighting-fast reactions occurring in our nervous system (Nichols, 2012). Therefore, changing these neurological reactions can permanently effect our conscious being (Blatter, 2012). The physical and neurological effects from the use and abuse of stimulants, sedatives, hallucinogens, organic solvents, and athletic performance enhancing drugs will be discussed in order to better comprehend why certain individuals expose themselves to such dangerous materials with seemingly no regard to the permanent consequences associated with such actions.
Ecstasy Effects | Information on Ecstasy,Club. Drugs,Pills and MDMA. Web. The Web. The Web.