Early Detection of Cardiac Dysfunction by Strain and Strain Rate Imaging in Children and Young Adults with Marfan’s Syndrome

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Methods (Background)
One part of the Marfan’s syndrome that has been researched was the cardiac dysfunction in younger children and young adults. There were a few methods that have been used to determine how to prevent Marfan’s syndrome in children and young adults. There is Conventional Echocardiography, Radiography Strain Rate Imaging, and Statistical analysis. In March 2010 to April 2011, Marfan’s syndrome’s patients attended the outpatient Pediatric Cardiology Clinic at Arkansas Children’s Hospital. This study focused mainly on people under 30 years of age. The patients in this experiment were all positive for Marfan’s Syndrome based on The Ghent criteria or a positive genetic test result for Fibrillin 1 mutation. Patients that had a history of cardiac surgery and with greater than mild mitral (heart) or aortic insufficiency were not included in this study. There was a control group of participants that received an evaluation of the echocardiography laboratory for chest pains, cardiac murmurs, or syncope and they were actually found to have normal cardiac anatomy, normal ventricular size, and function based on routine echocardiographic imaging. Medical records obtained the age, sex, race, height, weight, and medications at the time that the study started.
1. Conventional Echocardiography
The conventional echocardiography is a technique that is limited by geometric assumptions, image positioning errors, and the use of subjective visual methods. In the experiment, they also used a transthoracic echocardiogram, by which a technician obtains views of the heart by moving a small instrument called a transducer to different locations on the chest or abdominal wall. A transducer, which resembles a microphone, sends sound waves int...

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...syndrome patients had a lower longitudinal E strain rate at the basal septum compared to the controls (Figure 2). There were no significant differences between the two groups for the radial and circumferential strain. The differences that were shown were between the radial and circumferential strain rate (Tables 3 and 4). The patients with Marfan’s syndrome had a lower peak systolic radial strain rate and E-wave radial strain rate at the basal inferolateral segment. At the midventricular inferoseptal level, the peak systolic strain rate was noted to be higher in the patients with Marfan syndrome. The patients with Marfan syndrome had a lower E-wave circumferential strain rate at the midventricular inferior segment. (Angtuaco, Michael J., MD, Himesh V. Vyas, MD, Sadia Malik, MPH, Brandi N. Holleman, BS, RDCS,, Jeffrey M. Gossett, MS, and Ritu Sachdeva, MD, 2014).
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