As our understanding of the chemical basis for biology has grown, we have learned more about how molecules which constitute life. Many scientists are beginning to understand the connections between the physical and psychological matters and the molecules that cause them. As a result, we can now use these new understandings of medicine against any dangerous or unpleasant conditions. For example, depression can be treated with drugs that can revive the brain to its normal level.
Many medicines and drugs can change someone's physical and mental conditions, which can improve the risk of sickness and/or death. Proof of how medicine has improved is the fact that the average person today lives about 20 years longer compared to someone living during the beginning of the century. Although drugs have its benefits, they an also have severe addictive and destructive power.
Antibiotics- The most prescribed medicines in the United States are the antibiotics, drugs that fight infectious diseases like diphtheria, tuberculosis, cholera, and pneumonia. These diseases are cause by bacteria, which reproduce within the human body. Antibiotics work by attacking the microorganisms and selectively killing each of them. Before antibiotics were available, bacterial infections and similar diseases were among the top causes of death in the United States. Today, many of these diseases have been completely cleared out of its existence from developed nations. Unfortunately, bacterial diseases still claim many lives in Third World countries where antibiotics are less available and conditions are poor.
Antibiotics are classified onto several different categories. Some of the most common are penicillin, cephalosporins, and tetracylines. The penicillins were discovered in 1982 by Sir Alexander Fleming, a bacteriologist at the University of London. Penicillin is a fungus that Sir Alexander Fleming discovered after he came back from his vacation. It was not until 13 years later that penicillin was used on humans. This discovery has saved many lives, but as time progressed scientist discovered that there was still some bacteria that were resistant to penicillin.
Antiviral Drugs- in contrast to bacteria, viruses require the machinery of a host cell to reproduce. A virus, which usually consists of only DNA and protein, takes over a host cell and inserts its own DNA into the chromosomes of the host. This virus uses the host cell to produce more viruses. The new viruses infect other host cells and the cycle repeats. Viruses unfortunately do not respond to antibiotics.
In this essay, the author
Explains that scientists are beginning to understand the connections between physical and psychological matters and the molecules that cause them. they can now use these new understandings of medicine against dangerous or unpleasant conditions.
Explains that many medicines and drugs can change someone's physical and mental conditions, which can improve the risk of sickness and/or death.
Explains that antibiotics fight infectious diseases like diphtheria, tuberculosis, cholera, and pneumonia.
Explains that antibiotics are classified into several different categories, such as penicillin, cephalosporins, and tetracylines.
Explains that unlike bacteria, viruses require the machinery of a host cell to reproduce. a virus inserts its own dna into the chromosomes of the host to produce more viruses.
Explains that until recently, the only way to fight viruses was to prevent them through vaccination. a vaccination consists of introducing a small number of inactivated viruses into the body.
Explains that sexual characteristics are managed by molecules called hormones, chemical messengers that act on target cells usually located a long distance from where the hormone are secreted.
Explains that female sex hormones are called estrogen and progesterone and are secreted primarily by the ovaries.
Explains that the urge for sex has become a big issue in america. birth control pills and condoms have been used for many years, but have not completely prevented any of these problems.
Explains that sexual hormones are part of a larger class of compounds called steroids, characterized by their 17-carbon-atom, four-ring skeletal structure.
Explains that adrenocortical steroids are used for potent anti-inflammatory effects, while anabolic steroids, are synthetic analogs of testosterone, the male sex hormone.
Explains that 40% of americans develop cancer in their lifetime and about 1 in 5 die from it. cancer is a difficult disease to combat because cancer cells are modified form of human cells.
Explains that chemotherapy is the administration of drugs, either singly or in combination, over an extended period of time.
Explains that depressants, also known as tranquilizers or downers, dull the central nervous system. the amount of depression depends on the dose of the drug.
Explains that heavy drinkers increase the risk of heart disease, cirrhosis of the liver, respiratory diseases, and cancer. drinking while pregnant can result in birth defects in the newborn infant.
Explains that inhalants are drugs used for anesthesia, as well as those abused for a temporary high. they work by dissolving in nerve membranes and altering their function to depress nerve impulses.
Explains that narcotics are drugs that act on the central nervous system to produce an analgesic and sedutive effect. they differ from depressants in that they have a greater ability to reduce pain.
Antibiotics have been critical in fighting bacteria-caused diseases for the past 60 years. Bacteria in the human body are able to reproduce at a rapid rate and this is a huge problem when the bacteria are disease-causing. Antibiotics are drugs that are able to stop bacterial growth, and kill off bacteria in living organisms.
In this essay, the author
Explains that antibiotics have been critical in fighting bacteria-caused diseases for the past 60 years. they stop bacterial growth and kill off bacteria in living organisms.
Explains that humans face the real risk of a future without antibiotics. president obama is funding $30 million annually for the next five years to detect and prevent "superbug" infections by setting up regional labs to help identify outbreaks faster.
Explains the importance of preventing the antibiotic from reaching its main target (not being able to destroy the main organelles of the bacterium); changing the target so it does not do any main damage to the bacteria.
Explains that antibiotic-resistant bacteria multiply and multiply, causing the "superbug" in humans. frequent and improper prescribing of antibiotics is one of the main causes of resistance.
Antibiotics have always been some of the key contributing factors in the medicinal industry. An example of past antibiotics that greatly contributed to medicine is Penicillin. Penicillin was created in the late 1920s and received widespread clinical use during World War II by helping soldiers who were wounded and risked infection, because of its properties that prevent the creation of peptidoglycan in gram-positive bacteria. However, the older forms of Penicillin have been rendered completely useless because of the rapid evolution of bacteria to resist Penicillin. This has created an eternal race regarding whether people can develop the antibiotics to defeat resistant bacteria fast enough (McDonald, 2013).
In this essay, the author
Explains that antibiotics are key contributing factors in the medicinal industry. however, the amount of antibiotic resistant bacteria is rapidly rising.
Explains that antibiotics have always been key contributing factors in the medicinal industry, such as penicillin, which helped soldiers during world war ii. however, the older forms of penicillin have been rendered useless because of the rapid evolution of bacteria to resist.
Explains that antibiotics are as important today as they were in the past. the new antibiotic class neoglycosides is resistant to enzymatic inhibition while preventing bacterial protein synthesis.
Describes the recent outbreaks of antibiotic resistant bacteria, such as klebsiella pneumonia, mycobacterium tuberculosis, and the number of deaths caused by it.
Opines that basic cooperation between antibiotic companies and investment in research are necessary if any progress is to be made.
Explains that therapies for diseases that do not drive resistance include, but are not limited to, use of white cells that attack microbes, attacking the host instead of the bacteria, and blocking access to host’s resources.
Explains that new antibiotics can be discovered by reanalyzing old projects, such as linezolid, daptomycin, fidaxomicin and diterpene pleuromutilin.
Explains that exploiting natural chemical diversity of antimicrobial compounds allows modification of current antibiotic scaffolds into new antibiotics that will be very usable on humans and offer the potential to kill antibiotic resistant strains of bacteria.
Explains that biologists at the university of california have developed a revolutionary method that renders it possible to obtain information on how the drug will work in only about two hours.
Explains that combining known antimicrobials and off-patent non-antimicrobial drugs is a good strategy to develop cures to multidrug resistant pathogens.
Explains that intralytix has developed bacteriophages that specifically target antibiotic resistant bacteria such as pseudomonas aeruginosa, staphylococcus aureus, and e. coli.
In 1928, Alexander Fleming, a Scottish biologist, pharmacologist, and botanist, discovered the first natural antibiotic: Penicillin. All of you reading this have at some point in time made use of his discovery. Penicillin antibiotics were among the first drugs to be effective against many previously serious diseases, such as syphilis and infections caused by staphylococci and streptococci. Antibiotics in general remain one of the cornerstones of modern health care, acting as something we all hope to rely on when we get sick. We could very easily name the 20th century “the age of the antibiotic,” and it would be well deserved, indeed. But time is running out.
In this essay, the author
Narrates how they lay awake thinking about the future and the people they will never meet.
Explains that alexander fleming discovered the first natural antibiotic: penicillin, which was effective against syphilis and infections caused by staphylococci and streptococci
Explains that the who's first global report on antimicrobial resistance, released wednesday, says a post-antibiotic era, in which common infections and minor injuries can kill, is real for the 21st century.
Explains that estimates in the u.s. suggest 2 million people get antibiotic-resistance infections each year, and at least 23,000 die because current drugs no longer stop their infections. the who cannot provide global statistics because many countries have no estimates.
Explains that antibiotic resistance is resistance of a microorganism to an antimicrobial drug that was originally effective for treatment of infections caused by it.
Opines that the trend of combating minor injuries with unnecessary interventions must stop.
Opines that an untended cut or scrape may result in a stay at the hospital.
Opines that if i've scared you to the point where are considering your options moving forward, bravo people. you're the ones that are going to make me slightly less concerned for human civilization.
Opines that the body is a wondrous thing, capable of fighting off minor bacterial infections on their own.
Advises the health care force to prescribe the right antibiotic to treat the illness. only prescribe and dispense antibiotics when they are truly needed.
Urges policymakers to foster innovation, research and development of new tools, and promote cooperation and information sharing among stakeholders. this issue affects everyone on the globe, no matter the size of their wallet.
Opines that if public health policy becomes as serious as it has the potential to become, our lives will fundamentally change. we must work together to solve this problem.
Some of the bacteria that antibiotics treat are actually becoming resistant to the antibiotics meaning they lose all power. Without the power of antibiotics, these infections cannot be treated, which is proving to be a huge issue, as it’s spreading fast.
In this essay, the author
Opines that unless something changes in the near future, the power of penicillin could soon be diminished.
Explains that before the discovery of penicillin, the only available treatments for bacterial infections were toxic; arsenic, sulpha, and quinine.
Explains how fleming's publishing was discovered by ernst chain at oxford university, who persuaded howard florey to attempt to isolate the penicillin.
Explains how florey convinced the us government to fund research on producing mass quantities of penicillin through the use of deep-tank fermentation.
Explains that the molecular structure of penicillin was discovered by dorothy crowfoot hodgkin and robert burns woodward. both received nobel prizes for their efforts.
Explains that the discovery of antibiotics had a huge impact on healthcare in the mid-20th century, and continues to carry on to the present day.
Explains the difference in healthcare prior to penicillin use compared to recent years. in 1900, 30.4% of all deaths in humans were of children.
Explains that penicillin's success is slowly becoming inoperative. some of the bacteria that antibiotics treat are actually becoming resistant to them, meaning they lose all power.
Explains that antibiotic resistance has already caused a lot of damage, and it continues to spread.
Explains that antibiotic resistance can spread from the bottom of the food chain to other human beings. crops can be sprayed with water or fertiliser which contain drug resistant bacteria.
Explains that once antibiotic resistant bacteria enters the body, it is free to grow and take over the cell.
Opines that the only way to slow down this pandemic from worsening, is for new antibiotics to be created, as resistance occurs in a natural process, meaning it will take time.
Opines that antibiotic resistant infections will kill an extra 10 million people a year worldwide by 2050 unless more action is taken.
Opines that these statistics cannot be considered accurate as they do not include the impact it would have on healthcare treatments if antibiotics no longer worked.
Concludes that fleming's accidental discovery has had an immense impact on the lives of most humans worldwide for over half a century. extreme measures are needed to ensure that the power of antibiotic resistance bacteria starts to deteriorate.
Explains that the discovery of penicillin—new insights after more than 75 years of clinical use.
Cites walsh, f., kochanek, kd, murphy, and hoyert dl. superbugs kill'more than cancer'.
Explains that cdc office of infectious diseases (oid) (2013). antibiotic resistance threats in the united states.
Traditionally, the main goal of medicine, as in the practice of, has been to cure diseases and prevent death, a classic human vs. nature scenario. To overcome death, which is a part of all the life cycles in the natural world, is virtually impossible. However, I am not here to argue the validity of man's fight with nature. I am trying to explain that the traditional medical community has but one enemy, and its success with that enemy has been limited. However, as time passes, the main goals of medicine start to become questionable. Daniel Callahan addresses some of modern medicines new goals in the fifth chapter of False Hopes. Describing the second great attraction of modern medicine, he writes:
In this essay, the author
Opines that modern society reflects and encourages these thoughts very well. if a person believes his body is broken, ill, or in need of upgrading, the patient seeks quick and efficient treatments.
Analyzes how medical technology creates a "paradise of curves and muscles," but the side effects of those are not good for the body.
Explains that modern society views human limitations in areas such as pain tolerance and the biological sleep cycle as flaws in the body.
Opines that pain relievers aren't the only drugs people use to increase their productivity. stimulants are being made for those who wish to stay awake for several days.
Analyzes how jeremy rifken writes about the "age of access," which has values many people are starting to adopt.
Opines that the separation of man's physical body and conscious mind is the first step in fixing what they believe is a problem.
Explains morris, david, illness and culture in the postmodern age.
Explains that vaux, kenneth, ed., powers that make us human: the foundations of medical ethics.
Explains that the traditional medical community has only one enemy, and its success with that enemy has been limited. the shift in tradition to technology is characteristic of what jacques ellul calls the "technical phenomenon."
Opines that society is heading towards a technological state, and we are embracing it, too.
Drugs have been a part of society for thousands of years. Drugs were used to heal the sick and used by some for pleasure. Drugs were not first used as a means to earn money, but instead as a way to help others and ease pain. Not until the early to mid-nineteenth century, were drugs used to gain access to money, to reduce pain, and gain pleasure for some. Over time various drugs have contributed to the deterioration of society in some places.
In this essay, the author
Explains that drugs have been a part of society for thousands of years. they were used to heal the sick and to gain pleasure.
Explains that drugs can be placed into different schedules, ranging from one to five. the first drug schedule has a high potential for abuse and is not accepted for medical use in the united states.
Explains that schedule three drugs have a lower chance of abuse compared to schedule one and two, but still are highly abused.
Explains that the drug dimethyltryptamine is not accepted for medical use in the united states.
Explains that dimethyltryptamine is a powerful hallucinogen that will cause the user to want more.
Explains that dimethyltryptamine is not as abused as marijuana, heroin, or lsd. it is placed under schedule one because of its high potential for abuse.
Explains that dimethyltryptamine is a powerful hallucinogen that can be injected, smoked, or snorted or inhaled. it can cause fear, discomfort, increased heart rate, blood pressure, lung trouble, and distorted concept of time.
Explains how law enforcement agencies can detect and find dimethyltryptamine by obtaining a search warrant to search the suspect's personal property.
Opines that drugs have always been a part of our society and that will likely never change. law enforcement and the drug enforcement administration are at the top of their game in attempt to stop the use and trafficking of various drugs.
“Although Alexander Fleming discovered penicillin in 1928, it was not until ten years later that it was tested, first in animals, and then subsequently in humans”( animalaid.org.uk)
In this essay, the author
Explains the hair-raising euphemism 'cervical dislocation' for mice involves breaking the animal's neck, sometimes with your bare hands. for very young mice, you cut off the heads with scissors.
Explains procedures performed on living animals for purposes of research into basic biology and diseases, assessing the effectiveness of new medicinal products, and testing the human health and/or environmental safety of consumer and industry products.
Explains that the'modern' era of animal research started 150 years ago with the rise of physiology as a science.
Explains that although alexander fleming discovered penicillin in 1928, it was not tested until ten years later, first in animals, and then in humans.
Describes the most common primates, including mice, fish, rats, rabbits, guinea pigs and hamsters.
Estimates that more than 115 million animals worldwide are used in laboratory experiments every year.
Explains that rabbits, mice and rats are subject to tests that assess the safety of cosmetic, personal care, household products, chemicals, medical devices, and their component ingredients.
Explains that the chimp genome has become a powerful source of new information about human biology and evolution.
States that the humane cosmetics act was introduced in congress in march 2014, which would ban the use of animals testing cosmetics and their ingredients, and phase out the sale of cosmetic products containing animal tested ingredients.
States that acute toxicity testing is used to determine the danger of exposure to a chemical by mouth, skin, or inhalation.
Explains that repeated dose toxicity is used to evaluate chronic toxic effects, primarily effects on various organ systems, and establish a no-observed-effect-level (noel).
Explains that skin irritation tests determine the level of damage caused to skin such as itching, swelling, and inflammation.
Explains that a mutagen is an agent that changes the genetic information of an organism and increases the frequency of mutations.
Explains that pharmaceutical/toxicokinetic tests measure the rates of absorption, distribution, metabolism, and excretion of toxic substances.
Explains that in the bone marrow cytogenetic test, chemicals are administered to test animals, usually rats or mice, who are later killed.
Explains that a carcinogen is any substance or mixture of substances that induces or increases the incidence of cancer.
Describes the ethical issues involved in inflicting physical pain, psychological distress, and suffering on sentient creatures.
Explains that aspirin and paracetamol, commonly used to treat people, are highly poisonous to cats.
Opines that until they are killed at the end of the experiment, their lives are marked by pain and fear.
Explains that the nih budgeted nearly $30 billion for research and development.
Explains that trying to mirror human diseases or toxicity by artificially creating symptoms in mice, dogs or monkeys has major scientific limitations that cannot be overcome.
Explains modern methods include sophisticated tests using human cells and tissues, advanced computer-modeling techniques, and studies with human volunteers.
Explains that human cells, tissues and segments of dna can be processed and assessed through highly sophisticated, rapid screening techniques.
Explains that computer models can imitate the workings of the human body and duplicate the spread of disease so that researchers can predict how drugs will work and what effect they will have.
Explains that post-mortem studies can give clues about disease by examining bodies of people who have died.
Explains microfluidics chips contain tissue samples from various parts of the human body in tiny chambers linked by microchannels, through which a blood substitute flows.
Explains that sophisticated mri, cat and pet scanners allow detailed analysis of the brains and other organs of conscious patients without surgery.
States that animal aid campaigns for the use of human tissue in research as an alternative to animals, not only because it saves animals’ lives, but also because the results obtained are of direct relevance to people.
Explains that nine out of every 10 candidate medicines that appear safe and effective in animal studies fail when given to humans.
Opines that animal experimentation should be abolished. animals have no say in what they want, and it is not fair.
About 600,000 people die of heart disease in the United States every year–that’s 1 in every 4 deaths. Most of these patients either undergo angioplasty or coronary artery bypass surgery. The patients of these surgeries have to be kept under heparin, an anticoagulant treatment for the rest of their lives. Heparin, although a highly popular drug amongst cardiologists, has many side-effects and complications associated with it. The Medicines Company planned to target this drawback of heparin with the most promising drug in their pipeline, Angiomax.
In this essay, the author
Explains that about 600,000 people die of heart disease in the united states every year. most of these patients undergo angioplasty or coronary artery bypass surgery. the medicines company planned to target this drawback of heparin with angiomax.
Explains that meanwell's business strategy was to see a treasure in what other people perceived as trash. they took late stage failed drugs of other companies and redeveloped them.
Explains that angiomax was scavenged from biogen to replace heparin as an anti-coagulant. meanwell saw the value of the drug in its ability to produce predictable results and cause less number of complications.
Explains that the marketing strategy of the medicines company involves convincing doctors about the safety and efficacy of a test, convincing the pharmacist about its value, and approving the hospital budget.
Explains that pricing the drug should be priced between the upper and the lower limit of approx. $391 and $280. heparin's major competitor should adopt the 50/50 distribution of savings with the insurance/hospital payers.
Concludes that angiomax needs to be priced aggressively and dedicate itself to the higher risk market segments. efficient and effective marketing is critical for the success of the drug.
Antibiotics are medicines used to treat bacterial infections. Normally, our immune system includes special cells and chemical that can fight bacterial infection and stop them from multiplying enough to cause an infection. However, there are times when our immunity is low and the body is incapable to control an infection. That is when your body needs an antibiotic.
In this essay, the author
Explains that painkillers are drugs used to lessen pain. most of the pain killers belong to a class of medication called nsaids (non-steroidal anti-inflammatory drugs).
Explains that boosting blood pressure and canceling out the effect of few blood-pressure drugs can result in cardiac failure.
Recommends using a cold or hot compress, physiotherapy, exercises or rest for relief from neck or back pain, body ache or headache, instead of taking these drugs habitually.
Explains that antitussives and expectorants are used for dry coughs and mucus, and alcohol-based, so people often take them for getting high.
Recommends drinking plain water, honey, and warm water to soothe a cough, instead of treating it with some cough syrup.
Explains that ayurvedic medicines can be bought over-the-counter, but should not be taken without consultation from a qualified and licensed doctor. the duration, dosage, dietary limitations, and time of administration are critical to get maximum benefits and avoid potential side effects.
Explains the most commonly abused otc medicines and their possible side effects.
Explains that antibiotics are medicines used to treat bacterial infections. their immune system includes special cells and chemical that can fight them.
Medications
o Pain Medications
o Anxiolytic/Hypnotics
o Anti-depressants
o Mood Stabilizers
o Antipsychotics/Neuroleptics
o Anticonvulsants/Seizures Medications
o Stimulants
o Cognitive Enhancers
o Steroids
(Each of these medication categories will be automatically identified by the software based on the lists that follow.
In this essay, the author
Explains that each of these medication categories will be automatically identified by the software based on the lists that follow.
Explains that these sleep-inducing agents have less dependence than benzodiazepines and do not appear to have significant anxiolytic muscle relaxant or anti-convulsant properties. clinicians should be aware of drug interactions with other cns depressant medications.
Explains the side effects of benzodiazepine, including dizziness, headache, and sedative hypnotics.
Opines that anti-cholinergic medication causes mental slowing, especially in the elderly, where it may produce quiet or agitated confusional states.
Explains that anti-depressant medications are generally free of impact on cognitive processes, but two exceptions need to be considered: ssris and snri’s may produce insomnia which can lead secondarily to diminished attention and concentration.
Opines that tertiary amine tricyclics (amitriptyline, clomipramine, doxepin) may contribute to mental confusion, especially in the elderly, though their anti-cholinergic properties.
Explains that maoi's are seldom used as the first line treatment of depression. they remain excellent medications for patients with atypical depression characterized by oversleeping and overeating.
Advises that patients taking lithium or valproate should have periodic blood levels drawn. no clear, consistent or predictable impacts of these medications on cognition exist.
Explains that methylphenidate is produced under several different trade names (ritalin, ritalin-sr,
Opines that when prescribed appropriately for patients with add, depression or traumatic brain injury, these medications improve the ability to sustain, shift and direct attention. the possibility of stimulant abuse needs to be continued.
Explains that this stimulant medication is used to improve wakefulness in patients with narcolepsy, obstructive sleep apnea and other sleep disturbances.
Explains that these drugs are reported to produce mild to modest improvement in cognition in patients in the early to mid-stages of dementia of the alzheimer’s type. the most frequent side effects are gastrointestinal.
Opines and synthetic opioids are habit-forming, induce tolerance, and are used by patients for their anti-anxiety and/or soporific properties. they may compromise attention, concentration and performance on tasks that require mental speed, power, stamina and flexibility
Explains that benzodiazepines have potent anxiolytic, sedative, muscle relaxant, anti-convulsant and amnestic properties. sudden discontinuation may produce a wide variety of withdrawal effects, including anxiety, insomnia, panic attacks and impairment of memory and concentration.
Explains that conventional antipsychotics can produce extrapyramidal symptomatology, including dystonia, oculogyric crises, parkinsonian-like features.
Explains that blood levels should be measured on patients taking these medications. slowing of motor and mental activity may be associated with toxic dosages.
Explains that when taken in high potency forms or intravenously, steroids may produce quiet confusional states, agitated delirium, anxiety, depression, and/or psychosis.